Mental disorder

This study tests whether a short-term, intensive form of PTSD therapy can quickly reduce symptoms and improve thinking skills in military personnel. Participants receive either Cognitive Processing Therapy (CPT) or Eye Movement Desensitization and Reprocessing (EMDR) over a conde…

This study tests whether a type of talk therapy called Mentalization-Based Treatment (MBT) can help young people (ages 14–30) who are at high risk for psychosis avoid developing the condition. Participants will receive either MBT plus standard care or standard care alone for 24 w…

This study tests a new drug called Ulotaront (SEP-363856) to see if it can reduce symptoms like hallucinations and delusions in people with schizophrenia. About 522 adults experiencing an acute episode will receive either the drug or a placebo for 6 weeks. The main goal is to mea…

This phase 3 trial is testing whether the drug KarXT can safely and effectively treat schizophrenia in adolescents aged 13 to 17. About 166 teens will receive either KarXT or a placebo, and researchers will track changes in symptoms like delusions and social withdrawal. The goal …

This study tests whether adding team-building tools—like team charters, communication handoffs, and performance monitoring—to an existing school-based ADHD program (the Collaborative Life Skills Program) makes it work better. Researchers will compare the enhanced program to the s…

This study follows 300 adults with Parkinson's disease, essential tremor, or dystonia who receive deep brain stimulation (DBS). DBS uses a device implanted in the chest to send electrical pulses to brain areas controlling movement. Researchers will track symptom severity, medicat…

This phase 3 study tests whether KarXT, a new drug, can safely reduce schizophrenia symptoms in 250 Japanese adults experiencing acute psychosis. Participants first receive either KarXT or a placebo for 5 weeks, then all may receive KarXT for a year. The goal is to see if KarXT i…

This early-stage study is testing a single injection of a long-acting form of the drug brexpiprazole in healthy volunteers and people with schizophrenia. The main goal is to check if the injection is safe and tolerable, and how the body processes the drug. The trial involves 56 p…

This study tests a mobile health app called uMAT-R, designed to help Black adults recover from opioid or stimulant use and manage depression or anxiety. Participants are recruited from community treatment centers and use the app to track substance use and mental health symptoms. …

This study tests whether taking probiotics daily for 3 months can reduce symptoms of anxiety and depression in 60 adults with mild-to-moderate conditions. Participants will receive either probiotics, a placebo, or the antidepressant escitalopram. Researchers will measure changes …

This study tests whether deep brain stimulation (DBS) can help people with severe depression that hasn't improved with multiple treatments. Researchers will implant a device that sends electrical pulses to a specific brain area. The trial includes 100 adults and compares active s…

This study tests whether starting virtual reality-based rehabilitation within 24 hours of an acute ischemic stroke can improve arm muscle strength, thinking skills, and motivation to exercise. One hundred adults recently diagnosed with stroke will be randomly assigned to either v…

This study is testing whether a cochlear implant is safe and effective for infants and toddlers who are deaf in one ear. Sixty children will receive the implant and be followed until age 5. Researchers will compare their hearing abilities to children with normal hearing and to th…

This study tests whether deep brain stimulation (DBS) can help people with schizophrenia whose symptoms haven't improved with medication. First, doctors map the brain using electrodes to find the problem areas. Then, they implant a device that delivers mild electrical pulses to t…

This Phase 3 study tests whether KarXT, a combination of two drugs, can safely reduce manic symptoms in people with Bipolar-I disorder. About 274 participants hospitalized for mania will receive either KarXT or a placebo. The main goal is to see if KarXT improves scores on a stan…

This study tests whether adding KarXT to standard mood stabilizers (lithium, valproate, or lamotrigine) helps control manic episodes in people with bipolar I disorder. About 424 adults hospitalized for mania will receive either KarXT or a placebo for 5 weeks. The main goal is to …

This study compares IV iron to oral iron pills for treating moderate anemia after a C-section. The goal is to see if better iron levels can reduce the risk of postpartum depression. About 2,860 women will take part, and their mood will be checked 8 weeks after delivery.

This phase 2 study tests whether the sleep medication suvorexant can reduce insomnia in 76 adults aged 21–65 who have both alcohol use disorder and posttraumatic stress disorder. Participants take either suvorexant or a placebo for 14 days while trying to stop drinking. The study…

This study tests whether adding the drug brenipatide to standard treatment can delay the return of bipolar symptoms compared to a placebo. About 400 adults with bipolar I or II will self-inject the study drug or placebo for at least 6 months. The main goal is to see how long it t…

This study investigates whether ketamine, given as four intravenous infusions over two weeks, can reduce depression and alcohol cravings in adults who have both conditions. Participants are already in inpatient addiction therapy and are randomly assigned to receive either ketamin…

This study tests a talk therapy called CETA for 300 mothers in a low-income area of Lima, Peru. The therapy aims to reduce depression, anxiety, and stress, and improve parenting and children's well-being. Another 300 mothers receive standard support. Researchers will follow famil…

This phase 3 study is testing the long-term safety of KarXT, a new drug for managing mania in people with bipolar I disorder. About 450 participants, including those who completed earlier studies and new volunteers, will take KarXT along with standard mood stabilizers like lithiu…

This study is checking the long-term safety of a drug called KarXT in teenagers (13-17) with schizophrenia, and a combination of KarXT and KarX-EC in children (5-17) with irritability linked to autism. About 400 participants who completed earlier studies will take the drug for up…

This study tests a personalized version of deep brain stimulation (DBS) for people with severe obsessive-compulsive disorder (OCD) that hasn't improved with other treatments. Researchers will adjust the stimulation to target specific brain circuits linked to each patient's sympto…

This study tests whether adding brenipatide to standard schizophrenia medication is safe and effective. About 450 adults with schizophrenia will receive either brenipatide or a placebo for up to 12 months. The study looks at weight changes, cognitive function, and time to relapse…

This study compares a group program called Strength at Home (SAH) to standard court-mandated interventions for men who have used intimate partner violence (IPV) in Washington State. About 800 men will be randomly assigned to either SAH or treatment as usual, and researchers will …

This pilot study explores whether computer-assisted music remediation can improve memory, attention, and thinking in young people aged 18 to 30 who have had a first psychotic episode. Participants attend weekly group sessions using music software to practice memory and executive …

This study tests deep brain stimulation (DBS) in 20 people with severe depression that hasn't improved with other treatments. The device delivers electrical pulses to a brain region called the subcallosal cingulate, which may reset mood circuits. Researchers will record brain sig…

This study tests a treatment called FBET to reduce elopement (wandering away) in children aged 4–12 with autism. About 50 children will receive either FBET or usual care at community clinics. Caregivers will help track progress and practice skills at home.

This study is tracking 300 adults with schizophrenia in the U.S. who are prescribed a new drug called xanomeline and trospium chloride (X/T). Researchers want to know if patients prefer this drug over their previous treatment and how satisfied they are with it. The study will als…

This study tests whether a combination of physical activity, cognitive training, and dietary supplements can reduce depression symptoms and prevent memory or thinking problems in people with Major Depressive Disorder (MDD). Researchers will enroll 120 adults aged 50-80 who have M…

This 24-month study tests whether adding umbilical cord stem cells (AdiaVita) to glutathione therapy helps improve autism symptoms in children ages 3-12. About 100 kids will be randomly assigned to get either glutathione alone or glutathione plus stem cell infusions. Parents and …

This study tests whether a probiotic called Clostridium butyricum GKB7 can help children with autism. About 90 kids aged 4 to 15 will take either the probiotic or a placebo for a period. Researchers will also look for biomarkers in the gut and blood to better understand the gut-b…

This study tracks 1,500 adults with schizophrenia who start taking KarXT (xanomeline and trospium chloride) in routine clinical care across the U.S. Researchers will monitor how doctors adjust doses, side effects, weight changes, and relapses over time. The goal is to understand …

This study tests a therapy toolkit called Signs of Safety, designed for Deaf individuals who use American Sign Language and struggle with alcohol use disorder and PTSD. The toolkit adapts an existing therapy (Seeking Safety) to be Deaf-accessible. Researchers compare it to treatm…

This study tests whether adding sodium benzoate—a substance that affects brain glutamate—to standard antipsychotic medication can improve symptoms and thinking in people with treatment-resistant schizophrenia. About 90 adults who have not responded well to at least two antipsycho…

This study tests a short counseling program (about 4 sessions) designed to help pregnant and postpartum women in Cape Town, South Africa, keep taking their daily HIV-prevention pill (PrEP). Many women stop PrEP due to depression or trauma from violence. The program uses cognitive…

This study tests whether valbenazine can reduce involuntary muscle movements (tardive dyskinesia) in adults who still have symptoms while taking or after stopping another similar drug. About 50 people with schizophrenia, bipolar disorder, or major depression will take valbenazine…

This study tests a telehealth program called tele-ImPACT for infants aged 6-24 months who have an older sibling with autism, putting them at higher risk for social communication delays or language disorders. The program teaches parents strategies to support their child's communic…

This study tests whether adding a new drug called brenipatide to standard depression treatment can delay the return of major depressive symptoms. About 1000 adults with major depression who are already on stable medication will receive either brenipatide or a placebo as a shot, p…

This early-stage study is testing a long-acting injectable form of the drug KarXT in 116 people with schizophrenia. The main goal is to check the drug's safety and how the body processes it. Researchers hope this injectable version could offer a more convenient treatment option t…

This study is for people aged 18-35 experiencing their first episode of psychosis. Researchers will use genetic tests and MRI brain scans to see if certain markers can predict which antipsychotic drug (aripiprazole, risperidone, or clozapine) will work best. The goal is to improv…

This pilot study is testing whether combining cognitive behavioral therapy (CBT) with guided exercise can improve blood sugar control, reduce depression, and boost quality of life in Black men with type 2 diabetes. Eighty participants will receive 8 sessions of CBT, with half als…

This study is testing an experimental drug called MT1988 in 150 people aged 17 to 30 who are at high risk of developing psychosis. Participants take either a low dose, high dose, or placebo pill twice daily for 8 weeks. The main goal is to see if certain tests (like memory and sy…

This pilot study is testing a brain implant called deep brain stimulation (DBS) for people with schizophrenia that hasn't improved with standard treatments. The device delivers electrical pulses to specific brain areas to try to reduce psychotic symptoms. Ten participants will be…

This study tests a program called iCHART, designed to help teens aged 12-18 who have depression or suicidal thoughts. The program connects them to mental health care and safety planning. Researchers hope it will reduce suicide-related events by 50% compared to usual care.

This early-stage trial tests whether the experimental drug aticaprant is safe and tolerable when added to standard antipsychotic treatment for schizophrenia. About 64 clinically stable outpatients will receive either aticaprant or a placebo. The main goals are to see if the study…

This study tests esketamine nasal spray in 47 Korean adults with treatment-resistant depression (depression that hasn't improved with other treatments). Participants will use the spray themselves twice a week for 4 weeks. The main goal is to see if depressive symptoms improve, me…

This early study tests if deep brain stimulation (DBS) is safe and effective for people with severe depression that hasn't improved with other treatments. Twenty adults will have a device implanted in their brain and be monitored for five years. The device will be turned on and o…

This study will enroll 1,000 adults with both opioid use disorder and a mental health condition. Participants will receive standard medication for opioid use disorder, with some also getting a team-based support program called MISSION. The goal is to see if MISSION helps people s…

This Phase 3 trial tests whether the experimental drug NBI-1117568 can delay relapse of schizophrenia symptoms compared to a placebo. About 560 adults with stable schizophrenia will first receive the drug openly, then be randomly assigned to continue it or switch to placebo. The …

This phase 3 trial is testing the long-term safety of the drug NBI-1117568 in 600 adults with schizophrenia. Participants will receive the drug and be monitored for side effects over time. The study is open-label, meaning everyone knows they are getting the drug, and it focuses o…

This Phase 2 trial is testing whether HB-1, a tablet combining two blood pressure medications (telmisartan and verapamil), can safely reduce PTSD symptoms. About 200 adults aged 18-65 with PTSD will receive either HB-1 or a placebo daily for 12 weeks. The main goal is to see if H…

This study tests whether a combination drug called OLZ/SAM (olanzapine plus samidorphan) causes less weight gain than olanzapine alone in teenagers with schizophrenia or bipolar I disorder. About 220 teens aged 10-17 will take either the combo or olanzapine for 52 weeks. The main…

This study tests a stepped care program called PCT+2HOPE for women with opioid use disorder who have also experienced intimate partner violence and PTSD symptoms. The program adds group and individual therapy to standard medication treatment. Researchers will see if it helps wome…

This study tests whether the diabetes drug metformin can prevent blood sugar increases caused by statins in people with schizophrenia. Researchers will give 400 patients either metformin or a placebo alongside atorvastatin for six months. The goal is to see if metformin helps kee…

This study tests whether an internet-based depression treatment called cognitive behavioral therapy (iCBT-D) can prevent insulin resistance from getting worse in adults with HIV who are on antiretroviral therapy and have depression. Researchers will compare the online therapy pro…

This study tests whether MDMA-assisted therapy can help veterans with both PTSD and alcohol use disorder. Eighty veterans will receive either a full dose of MDMA or a low-dose placebo during three therapy sessions. Researchers will measure changes in PTSD symptoms and drinking ha…

This study is testing how the drug KarXT affects bladder function and overall safety in 60 adults with schizophrenia over 12 months. Participants will stop their current antipsychotics and take KarXT to see if it causes any urinary problems. The goal is to ensure the drug is safe…

This study tests whether a combination of umbilical cord stem cells and glutathione can safely improve autism symptoms in 100 people aged 3 and older. Participants receive either the stem cell product plus glutathione, or a placebo plus glutathione, with the option to switch grou…

This study tests whether using a person's genetic information to guide medication choices leads to better recovery for people with mood, anxiety, or psychotic disorders. Over 2,500 participants will receive either standard care or personalized medication advice based on their gen…

This study is testing whether a portable eye-tracking device can accurately screen 9-month-old infants for autism spectrum disorder (ASD). Over 2,000 babies will watch short videos while cameras track their eye movements. Researchers will then compare these results with standard …

This study tests whether a non-invasive brain stimulation technique called TMS, given within two weeks of a traumatic event, can prevent chronic PTSD. Researchers will measure changes in brain activity linked to fear and threat. The goal is to see if early intervention can reduce…

This study tests two self-care methods—virtual ear acupressure and Baduanjin qigong—to prevent or reduce period pain in 145 women aged 16–35 with primary dysmenorrhea. Participants will be randomly assigned to one of three groups and practice their assigned technique for 12 weeks…

This study tests different combinations of an online program called CARRII, designed to help Native American women reduce their risk of alcohol-exposed pregnancy. Over 500 participants will be randomly assigned to one of eight versions of the program for three months. The goal is…

This pilot study tests a depression prevention program called Brief Interpersonal Psychotherapy-Adolescent Skills Training (B-IPT-AST) for teens aged 13-17 with mild symptoms. The program includes 6 sessions (4 group, 2 individual) and is compared to usual services. Researchers w…

This study tests whether taking part in racial justice activism can prevent depression and reduce physical stress in Black and Latinx young people aged 15-20. Researchers will measure mood, stress hormones, and health markers over two years. The goal is to see if activism can be …

This study is testing a short, 6-session group program called Resilience Training for Teens. The goal is to see if it can help high school students who have mild symptoms of depression, anxiety, or unusual feelings avoid developing more serious mental illnesses. The study will in…

This study tests a simple talking therapy for heart surgery patients while they are still in the ICU. The therapy uses a visitor book with photos and family messages to help patients process stressful memories. Researchers hope this can prevent posttraumatic stress disorder (PTSD…

This study tests whether chewing xylitol gum during pregnancy can reduce the risk of preterm birth and low birthweight. 6,000 pregnant women in Malawi will chew either a high or low dose of xylitol gum or a placebo gum. The goal is to see if improving oral health with xylitol lea…

This study tests a special therapy for stroke patients in the hospital to help them avoid falls after they go home. Falls are common after a stroke and can cause injuries or fear of falling. The therapy includes extra exercises and education about fall risks. Researchers will tra…

This study tests an experimental oral drug called CYB003 in 220 adults with major depressive disorder. Participants receive either CYB003 or a placebo alongside their usual treatment. The goal is to see if CYB003 safely reduces depression symptoms better than placebo.

This study tests a smartphone app designed to help teenagers aged 14-18 who self-harm and are not currently in therapy. The app teaches coping skills and connects them with support through a friendly chatbot. The goal is to see if the app is easy to use and helps reduce self-inju…

This study from Yale University will test whether 20 minutes of moderate cycling can reduce obsessive thoughts, compulsive urges, and improve thinking flexibility in adults with OCD. Fifty participants will be randomly assigned to either moderate or low-intensity cycling. Researc…

This study looks at how sensory sensitivity affects sleep and emotions in autistic children ages 6-10. Researchers will test a simple bedtime routine called Power Down, where caregivers give their child a gentle massage to help them relax before sleep. The goal is to see if this …

This study tests a program called CAPABLE Transplant, where an occupational therapist, nurse, and handy worker visit people at home over 4 months. The goal is to help kidney transplant candidates who are currently inactive on the waitlist become active again, and to improve their…

This study tests two digital mindfulness programs—one live over Zoom and one self-paced app—to see if they can reduce depression in younger breast cancer survivors. It includes 402 women diagnosed at or before age 50 who finished cancer treatment at least 6 months ago and have el…

This study tests a new way to treat post-traumatic stress disorder (PTSD) using personalized brain stimulation. Researchers use an EEG to find the right frequency for each person, then apply transcranial magnetic stimulation (TMS) to the frontal lobe. The trial includes 20 vetera…

This study tests a group therapy program called the Unified Protocol for adults with emotional disorders such as anxiety, depression, and related conditions. The program teaches skills like emotional awareness, flexible thinking, and facing fears. Researchers want to see if it im…

This study tests whether a four-session mindfulness class (Primary Care Brief Mindfulness Training) can help veterans reduce symptoms of anxiety, depression, and PTSD compared to a problem-solving class. The classes are designed for primary care settings and focus on meditation, …

This trial tests whether starting PTSD treatment with one type of talk therapy and then switching to another based on early progress leads to better symptom relief. About 430 adults receiving care at federally qualified health centers will take part. The study compares different …

This study tests whether a drug called MDMA, given alongside therapy, can help veterans with PTSD feel better. About 52 veterans will receive a dose of MDMA during therapy sessions, either alone or in a group. The goal is to see if this approach is safe and reduces PTSD symptoms.

This study tests whether a brief form of talk therapy, called Prolonged Exposure for Primary Care (PE-PC), can reduce PTSD symptoms in first responders and frontline healthcare workers. Participants receive 4-6 weekly 30-minute sessions either by telehealth or in person, delivere…

This study tests whether yoga-based exercises can help veterans with schizophrenia, schizoaffective disorder, or bipolar 1 disorder improve their ability to function in daily life—like socializing, working, and managing leisure activities. About 112 veterans will be randomly assi…

This study tests whether a drug called psilocybin (the active ingredient in magic mushrooms) combined with therapy can help women with PTSD from sexual assault. About 70 women will receive the treatment in a controlled setting. The goal is to see if it reduces PTSD symptoms and i…

This study tests whether a mobile app with short weekly exercises can help first-time parents manage emotions and reduce depression during pregnancy. About 572 expectant mothers and fathers in Singapore will use the app or receive standard care. Participants will also wear a Fitb…

This study tests whether a smartphone app that teaches mindfulness can help reduce stress in people who have finished cancer treatment. About 345 cancer survivors will be randomly assigned to use the app right away or wait three months. The goal is to see if the app makes a real …

This trial tests whether adding either dexmedetomidine or magnesium sulphate to the standard numbing medicine bupivacaine improves pain control after chest surgery. About 60 adults with cancer undergoing thoracotomy will receive one of three nerve-block combinations. The main goa…

This study tests whether a specially designed bright light can improve cognitive problems like memory and attention in people with major depressive disorder. 120 adults with depression and cognitive issues will receive either the bright light or a dim red placebo light for four w…

This study compares two types of nerve blocks for pain relief in women undergoing breast cancer surgery. One group receives a single-level block, while another receives a two-level block, with some patients also getting the medication dexmedetomidine. The goal is to see which app…

This Phase 3 study tests whether CYB003, a psilocin analog (related to the active ingredient in magic mushrooms), can safely reduce depression symptoms in 330 adults with major depressive disorder. Participants receive either one of two doses of CYB003 or a placebo, along with ps…

This study tests whether using the soundBrilliance app—which combines enhanced music, natural visuals, and spoken guidance—can help people aged 13 and older manage anxiety, depression, and stress. Over 12 weeks, participants use the app at least 4 days per week and report their m…

This Phase 3 trial tests whether the drug combination KarXT + KarX-EC can safely reduce psychosis symptoms (like hallucinations and delusions) in people with Alzheimer's disease. About 325 participants aged 55-90 will receive either the drug or a placebo. The study is currently r…

This study tests whether clemastine, a common antihistamine, can improve brain white matter and make antidepressants work better for adults over 60 with depression. Eighty participants will receive either clemastine or a placebo alongside their antidepressant. The goal is to see …

This study explores whether a type of talk therapy called behavioral activation, delivered via video call, can help older adults who are involved with Adult Protective Services due to neglect or self-neglect. The therapy aims to reduce depression and apathy, and improve daily act…

This study tests a program called Invest in Play (iiP) for parents of children aged 6-12 with problem behaviors. About 180 families will be randomly assigned to the program or a control group. Parents will fill out surveys to see if the program reduces challenging behaviors and i…

This study tests whether taking photos of things related to well-being and discussing them with a therapist can help people with stress-related illness. Participants take pictures with their phone before sessions, and the therapist uses the photos to guide conversations about wel…

This study explores whether a mobile app called FlowMD can help adults with mild anxiety. Participants use the app for 1-5 minutes of guided breathwork each day for four weeks. Surveys measure changes in anxiety levels and how easy the app is to use. The goal is to see if this ap…

This study tests whether wearing a headset that delivers a flickering 60Hz white light for 30 minutes a day can help ease depression symptoms. Adults with major depressive disorder will use the device at home for three weeks. Researchers will measure how well people stick with th…

This study tests whether combining home-based brain stimulation (tDCS) with virtual speech therapy can improve communication in adults with primary progressive aphasia, a language disorder often caused by Alzheimer's disease. Eighty participants will receive either active or plac…

This study tests whether adding a crisis response plan (CRP) to prolonged exposure (PE) therapy helps reduce suicidal thoughts and behaviors in people with PTSD. Researchers will compare PE plus CRP to PE with standard care in 100 adults. The goal is to find a better way to suppo…

This study tests a new online therapy platform called Teleo, designed specifically for children with anxiety or mood disorders. Researchers want to see if kids are more engaged during therapy sessions on Teleo compared to standard video calls. About 156 children will take part, a…

This phase 3 study is testing an oral drug called DT120 (related to LSD) against a placebo in 165 adults with major depressive disorder. Participants will take the drug or placebo for 12 weeks, followed by a 40-week period where everyone can receive DT120. The main goal is to see…

This study tests whether a noninvasive brain stimulation technique called tDCS can reduce depression in people with multiple sclerosis. Participants use a headband-like device at home for 30 minutes a day over 30 days, while listening to mindfulness meditation. Half receive real …

This study tests whether a version of Dialectical Behavior Therapy (DBT) skills training, adapted for autistic adults, is feasible and helpful for those with emotion regulation difficulties. The program uses simplified language, more visuals, autism-relevant examples, and hands-o…

This study tests whether sitting in front of a bright lightbox for 60 minutes each morning can improve sleep and overall well-being in veterans who have traumatic brain injury, post-traumatic stress disorder, and chronic pain together—known as the polytrauma clinical triad. The t…

This small study tests if a non-invasive device that stimulates the brain during sleep can increase deep sleep in adults with depression. Researchers want to see if better deep sleep helps with memory, thinking, and mood. Participants wear a headband and activity tracker at home …

This study tests an experimental oral drug called GXV813 in 142 hospitalized adults with schizophrenia. The goal is to see if it safely reduces symptoms like hallucinations and withdrawal during an acute episode. Participants are randomly assigned to receive GXV813 or a placebo, …

This study tests whether a videoconference with a psychologist before anterior cruciate ligament (ACL) knee surgery can reduce pain afterward. It includes 126 anxious patients scheduled for first-time ACL reconstruction. The main goal is to compare pain levels the night after sur…

This Phase 2 trial tests whether a single injection of RE104 can reduce anxiety symptoms in 64 adults with generalized anxiety disorder, compared to a placebo. Participants receive one dose and are followed for four weeks to measure changes in anxiety severity using a standard ra…

This study tests whether cariprazine (Vraylar) can safely ease depressive episodes in teens aged 10-17 with bipolar I disorder. Around 380 participants will receive either the drug or a placebo for 6 weeks, with dose adjustments based on response. The goal is to see if the drug i…

This study tests whether a single dose of psilocybin (the active ingredient in magic mushrooms) combined with intensive therapy can help people with chronic posttraumatic stress disorder (PTSD). Fifteen adults with moderate to severe PTSD will receive the treatment over a week. T…

This study tests whether a chatbot that uses motivational interviewing can help college students with anhedonia (loss of interest or pleasure) feel more emotional arousal. Eighty participants will interact with the chatbot or a control version, and their brain activity will be sc…

This pilot study is testing a device that sends a mild electrical current to the brain (tACS) to see if it can reduce anxiety and improve sleep in people with generalized anxiety disorder and chronic insomnia. Thirty adults will receive 20 sessions over four weeks. The goal is to…

This study compares two types of speech therapy for people with aphasia, a language disorder often caused by stroke. One therapy, called Semantic Feature Analysis (SFA), helps people name objects by describing their features. The other adds metacognitive strategy training (SFA+MS…

This study tests whether psilocybin, the active ingredient in magic mushrooms, combined with talk therapy can safely help cancer survivors with depression or anxiety. Twenty adults who have finished cancer treatment and have no brain involvement will receive a single dose of psil…

This study is testing a 12-week early intervention program for preschoolers (ages 2 to 5) with developmental disorders like autism or intellectual disability. The program provides 12 hours of therapy each week, either at a center or at home, aiming to improve social communication…

This study tests whether a chatbot that uses motivational interviewing can help college students with anhedonia (loss of interest or pleasure) update their beliefs in a more positive way. 80 participants will interact with the chatbot or a control version over several sessions. T…

This study is testing whether a single dose of psilocybin (the active ingredient in magic mushrooms) combined with mindfulness-based therapy can help people with PTSD. Thirty adults with PTSD will receive psilocybin along with either standard support or extra mindfulness training…

This phase 3 trial tests a single oral dose of VQW-765 versus placebo for quickly reducing acute anxiety in adults with social anxiety disorder. About 500 participants will take the drug as needed before anxiety-provoking situations. The study measures distress levels during and …

This study compares two types of nerve blocks to see which provides better pain relief after total hip replacement. Fifty adults having hip surgery will receive one of the two blocks. Researchers will measure pain scores and how much extra morphine is needed. The goal is to impro…

This study tests whether adding a computer task called gaze-contingent music reward therapy (GCMRT) to standard cognitive behavioral therapy (CBT) helps reduce anxiety in children aged 8 to 17. In GCMRT, children look at faces on a screen while pleasant music plays or stops depen…

This study is testing whether a single session that combines two types of brain stimulation (TMS and tACS) with psychotherapy can safely and feasibly help people with major depression that hasn't improved with standard treatments. The researchers will enroll 30 adults aged 18-70 …

This pilot study tests whether a peer support program can help young adults (ages 18-27) recently discharged from a psychiatric hospital. Participants get one-on-one and group meetings with trained Peer Support Specialists and recovery organizations, while a comparison group rece…

This study tests whether a 16-week behavioral therapy called Pivotal Response Treatment (PRT) works better when done at a center or at home for young children with autism who have language delays. Researchers will compare both groups to children receiving usual care. The goal is …

This study tests a 12-week behavioral therapy program delivered via video calls to help autistic youth (ages 4-17) cope with insistence on sameness—difficulty tolerating changes in routine. Parents are trained to support their child during weekly sessions. The goal is to see if t…

This Phase 3 trial is testing whether an experimental drug called NBI-1065845 can help reduce depression symptoms in adults who haven't responded well to standard antidepressants. About 200 participants will take either the drug or a placebo alongside their current antidepressant…

This pilot study tests whether esomeprazole (Nexium), a common stomach acid medication, can improve social communication in 25 children with autism aged 2 to 6. Over 12 weeks, kids take the drug daily, and researchers measure changes in social behavior using standard rating scale…

This study tests whether answering a short daily survey about a specific traumatic memory can reduce the intensity and frequency of intrusive PTSD symptoms. Fifty adults with PTSD will either complete surveys about their trauma memory or about a neutral memory for 10 days. Resear…

This study tests two different ultrasound-guided nerve blocks to see which provides better pain relief for children aged 6 to 12 after chest surgery. Seventy-five children will receive either a subtransverse process interligamentary plane block or a rhomboid intercostal block com…

This study tests a new medicine called KYN-5356 to see if it can help with thinking and memory problems in people with schizophrenia. About 150 adults who are stable on their current schizophrenia treatment will take either a low, medium, or high dose of the drug or a placebo for…

This study tests whether certain supplements—prebiotics, probiotics, omega-3s, and vitamin B1—can reduce ADHD symptoms in children aged 6 to 12. Over 12 weeks, 68 kids will receive either a gut-focused supplement, a brain-focused supplement, a combination, or a placebo. Researche…

This study tests whether adding magnesium vitamin B6 to usual treatment can reduce depression, anxiety, and stress in people experiencing their first episode of bipolar I disorder. Forty adults aged 18-50 will take either the supplement or a placebo three times daily for four wee…

This study looks at whether acupuncture can improve symptoms of ADHD in children ages 6 to 12. Researchers will give some kids acupuncture plus herbal medicine, and others just herbs, then compare results using parent surveys and interviews. The goal is to see if adding acupunctu…

This study tests whether a chatbot that uses motivational interviewing can improve how people with anhedonia (loss of interest or pleasure) respond to social rewards. Eighty college students with elevated depression and anhedonia will interact with the chatbot regularly over a pe…

This study looks at whether a computer-based attention training program can help adults with social anxiety disorder. Participants will complete eight sessions over four weeks, either doing the active training or a placebo version. The goal is to see if the training reduces anxie…

This study tests whether a non-invasive brain stimulation technique called tDCS can improve social communication and reduce repetitive behaviors in adolescents with autism. Researchers will use machine learning to analyze brain activity (EEG) and clinical data to predict who will…

This study from Stanford University tests whether two breathing techniques—cyclic sighing and box breathing—can lower anxiety, compared to hypnosis or listening to an audiobook about stress. Eighty adults will practice daily for 4 weeks and have their brain activity and heart rat…

This study tests a program called ACT Together for parents of children with disabilities. The program includes six online lessons and weekly phone coaching sessions with a trained therapist. It teaches skills to handle stress and difficult emotions. Researchers want to see if the…

This phase 2 trial at MD Anderson Cancer Center is testing whether psilocybin-assisted psychotherapy can safely help ease depression and anxiety in 30 adults with advanced cancer who are on maintenance therapy. Participants receive either psilocybin or a placebo (niacin) along wi…

This study tests whether using a virtual reality mindfulness app can lower anxiety in people undergoing fertility surgeries. 500 participants will be randomly assigned to either standard care or a VR experience before their procedure. Researchers will measure anxiety levels and p…

This trial tests whether shining a specific type of near-infrared light on the forehead—called transcranial photobiomodulation (tPBM)—can improve attention and reduce impulsivity in adults with and without ADHD. Participants receive either active tPBM or a sham (fake) treatment f…

This pilot study tests a self-management program based on cognitive behavioral therapy to help people who survived acute respiratory failure and now struggle with anxiety. Sixty ICU survivors will either receive the program or usual care. The goal is to see if the program is prac…

This study tests an experimental drug called RAP-219 for people with bipolar I disorder who are currently experiencing a manic episode. About 250 participants will receive either RAP-219 or a placebo daily for 21 days. Researchers will measure changes in manic symptoms using a st…

This study tests whether an online Spanish course can teach parents of young children with autism to use Pivotal Response Treatment (PRT) to boost communication and social skills. Forty Spanish-speaking families with children aged 2 to 5 will take 12 weeks of online lessons, atte…

This study tests whether short, calming virtual reality (VR) sessions can safely reduce anxiety, agitation, and delirium in adult intensive care unit (ICU) patients. Thirty participants will watch nature-based VR content using a headset. The main goal is to see if this approach i…

This study tests whether folinic acid (a form of vitamin B9) can reduce irritability and improve behavior in 150 children aged 3 to 6 with autism. Half will get folinic acid, half a placebo, for 9 weeks. Researchers will also check if it helps with communication, sleep, and gut s…

This study tests whether combining progressive muscle relaxation and guided imagery can lower stress, anxiety, and depression in people with stable coronary artery disease. Forty adults will be split into two groups: one gets eight sessions of these mind-body techniques over four…

This study aims to find helpful treatments for healthcare workers suffering from PTSD and distress due to work-related trauma. In the first phase, 120 participants will be randomly assigned to either a music-listening or a writing session over two weeks. Those who still have PTSD…

This study tests whether using a genetic test to guide antidepressant dosing helps teens aged 12-17 with anxiety or depression. About 452 teens will be randomly assigned to either gene-guided dosing or standard dosing. The goal is to see if the genetic approach leads to more remi…

This study tests whether a type of talk therapy called behavioral activation (BA) can help treat depression in older adults who have survived cancer. Participants will receive BA or supportive psychotherapy remotely via video or phone over 10 weeks. The goal is to see if BA reduc…

This study tests whether using a hand extension rubber during IV insertion can reduce pain, anxiety, and improve satisfaction. Researchers will enroll 114 adults who need an IV and randomly assign them to use the rubber or not. The goal is to see if this simple, low-cost distract…

This Phase 3 study is testing the long-term safety of an experimental drug called NBI-1065845 (TAK-653) in 850 adults with major depressive disorder who haven't gotten enough relief from standard antidepressants. Participants take the drug alongside their usual antidepressant for…

This study tests whether shining a low-level infrared light on the forehead (called photobiomodulation) can improve autism symptoms like inattention, impulsivity, and social difficulties. Researchers will compare the real light treatment to a sham (inactive) device in 280 people …

This study tests a non-invasive light therapy called transcranial photobiomodulation (tPBM) to see if it can improve attention, memory, and brain oxygen levels in adults with ADHD. Researchers will give repeated sessions of infrared light to the forehead area and measure changes …

This study tests whether adding a probiotic called Ecologic Barrier to standard treatment helps adults with irritable bowel syndrome (IBS) who also have stomach issues and anxiety, depression, or stress. Sixty participants will receive either standard care or standard care plus t…

This study looks at whether walking in a natural setting (like a park) is better for reducing stress, anxiety, and improving mood compared to walking in a built-up commercial area. 216 adults with prediabetes will walk 150 minutes per week for six weeks in each environment, with …

This study tests whether playing an immersive virtual reality game during painful burn treatments (like dressing changes) can reduce pain and the need for opioid painkillers. Fifty adult burn patients will be randomly assigned to receive either standard care alone or standard car…

This study tests whether a non-invasive brain stimulation technique called tDCS can reduce pain in people with Complex Regional Pain Syndrome (CRPS). Thirty-two adults with active CRPS will receive either real or sham stimulation over several sessions. The goal is to see if this …

This study tests a new drug called ABBV-932 for adults with generalized anxiety disorder (GAD) who still have symptoms despite taking antidepressants. About 315 participants will receive either ABBV-932 or a placebo alongside their current antidepressant for 6 weeks. The goal is …

This study tests whether a non-invasive brain stimulation technique called TMS, combined with language therapy, can improve speech in people who have aphasia after a stroke. Researchers will compare real TMS to a sham (fake) version in 63 participants who had a stroke 2 to 6 week…

This study is testing the safety and tolerability of an experimental drug called ABBV-932 for people with bipolar I or II disorder who are currently in a depressive episode. About 200 adults will take the drug as capsules for 26 weeks, with regular check-ups and tests to monitor …

This study tests whether the drug arbaclofen can improve social function, anxiety, and quality of life in children and adolescents with autism. Participants first receive a single dose of arbaclofen or placebo to see if brain-wave changes can predict who will benefit. Then everyo…

This study looks at whether using a weighted blanket during intravenous cancer treatment can help lower anxiety, stress, and depression, and improve comfort. About 152 adults with solid cancers who are starting their first IV therapy will be randomly assigned to receive either a …

This study tests an internet-based cognitive behavioural therapy (ICBT) program designed specifically for Canadian public safety personnel (like police, firefighters, and paramedics) who have symptoms of depression, anxiety, or posttraumatic stress. Participants choose their leve…

This study tests whether a parent-led online program can improve sleep in autistic children aged 3 to 7 years. About 130 children will be randomly assigned to one of two behavioral sleep programs for 10 weeks. The goal is to see if the structured program reduces insomnia symptoms…

This study tests a behavioral program called InSTILL for nursing home residents who feel stressed or depressed. Twenty participants will attend six sessions to learn life management and emotion regulation skills. The main goal is to see if the program is practical and well-liked,…

This study tests whether a single dose of the experimental drug SYT-510 can reduce anxiety-related brain activity and behavior in 24 adults with generalized anxiety disorder. Participants will receive either the drug or a placebo, then switch after a washout period. The goal is t…

This study tests a sleep health program for teens aged 10-19 who recently had a concussion. The goal is to see if better sleep helps symptoms go away faster and improves sleep quality, mood, and school engagement. Participants will be randomly assigned to the sleep program or sta…

This pilot study tests whether adding brief guided mindfulness exercises (via a smartphone app) between sessions of accelerated brain stimulation (aiTBS) is feasible and acceptable for people with major depression. Twenty adults already receiving aiTBS as standard care will pract…

This study tests whether a smartphone-based program is practical and helpful for young adults aged 18-25 who have ADHD and drink heavily. Participants use the app for 31 days to improve awareness and self-control around alcohol. The goal is to see if the app reduces binge drinkin…

This study tests a smartphone app called VoiceLove that lets mothers of babies in the NICU record voice messages for their infant. Researchers want to see if using the app helps reduce symptoms of postpartum depression compared to standard care. About 150 mothers will take part, …

This study tests a short, virtual therapy for pregnant women and new mothers with PTSD. About 90 participants will either receive the therapy or standard care. The goal is to see if the therapy is practical and well-liked, and to measure its effect on PTSD and depression symptoms…

This study tests whether taking vitamin D daily for 8 weeks helps healthy adults keep their thinking, simple physical tasks, and mood steady during very stressful situations. 52 participants will take either vitamin D or a placebo, then perform tasks while wearing a belt that giv…

This study tests a hybrid dialectical behavior therapy (DBT) program for veterans with PTSD who have already completed inpatient treatment. The goal is to reduce lingering symptoms and prevent relapse. About 24 veterans will take part, combining in-person skill groups with online…

This study tests whether a simple four-square breathing exercise done before breastfeeding can lower anxiety and improve well-being in mothers whose babies are in the neonatal intensive care unit (NICU). About 70 mothers will be split into two groups: one does the breathing exerc…

This study compares two ways of delivering cognitive processing therapy (CPT) to pregnant women with posttraumatic stress disorder (PTSD). One group receives standard weekly therapy sessions for 12 weeks, while the other gets an intensive schedule of 10 sessions over just 5 days.…

This study tests whether a new type of virtual reality therapy can improve arm function in people who had a stroke. Fifty-four participants will try different versions of mirror therapy, some with added attention-focusing techniques. The goal is to see which approach works best f…

This study tests a program called Parenting STAIR Modular (PSTAIR-M) for military-connected mothers who have experienced trauma and have young children aged 2-10. The program helps mothers manage PTSD and depression symptoms while improving their parenting skills. Researchers wil…

This study aims to train psychotherapists to deliver personalized, evidence-based therapies to cancer patients and their caregivers who are experiencing high levels of distress. Therapists will choose from treatments like cognitive behavioral therapy and mindfulness-based stress …

This study tests whether eating only during an 8-hour window each day (time-restricted eating) can help people with bipolar disorder who are overweight and depressed lose weight and improve their mood. Forty adults will be randomly assigned to either follow this eating pattern fo…

This study tests a 10-session LGBTQ-affirmative cognitive behavioral therapy (CBT) delivered via telehealth to sexual minority women who drink heavily and have anxiety or depression. Researchers will compare it to standard LGBTQ-affirmative therapy to see if it better reduces hea…

This study tests whether using virtual reality (VR) goggles during a colposcopy can lower women's anxiety, stress, and pain. About 60 women scheduled for the procedure will either receive standard care or wear a VR headset showing calming content. The goal is to see if this simpl…

This study tests whether using a gentle brain stimulation device (tDCS) twice a day at home can help people with depression who are not on medication. Thirty participants will be split into three groups: one gets real stimulation, one gets a sham (placebo) device, and one waits w…

This study tests a non-invasive device that gently stimulates a nerve in the ear to see if it can reduce depression symptoms in people who have had a heart attack or related heart problem and a stent placed. About 120 adults will use the device at home for 8 weeks, and their mood…

This Phase 1 study is testing the safety and brain effects of DMT, a psychedelic drug, in 60 adults with depression and healthy volunteers. Participants receive low or medium doses of DMT, THC, or a placebo, and researchers monitor mood, anxiety, and brain activity. The goal is t…

This pilot study is testing a 12-session virtual therapy that combines two proven treatments—one for PTSD and one for chronic pain—into a single program. Researchers want to see if this integrated approach is feasible and acceptable for adults who suffer from both conditions. The…

This early-stage study tests whether a new medicine called BI 3031185 is safe and well-tolerated in adults with borderline personality disorder (BPD) or attention-deficit/hyperactivity disorder (ADHD). About 96 participants will receive either the drug or a placebo in a crossover…

This study tests whether a web-based program called autimia, which uses cognitive behavioral therapy techniques, can help adults with autism spectrum disorder manage stress and improve their well-being. About 236 participants will either use autimia plus their usual care, or just…

This study compares two drugs, pramipexole and escitalopram, to treat major depression in people with HIV. Some participants also have mild memory or thinking problems. The goal is to see which medication is safer and more effective at easing depression symptoms. About 186 adults…

This study tests whether adding poverty alleviation (like financial support) to group talk therapy helps low-income rural women in Bangladesh with depression more than therapy alone. Six hundred women aged 18-45 with depression and economic hardship will be randomly assigned to e…

This study tests whether a new drug called HNK can quickly improve symptoms in people with major depression that hasn't responded to other treatments. About 50 adults aged 18 to 70 will receive four infusions of HNK and four of a placebo over several weeks, with their depression …

This study tests whether adding a probiotic (Lactobacillus crispatus) to the antidepressant sertraline helps reduce depression symptoms more than sertraline alone in teens aged 12-18 with major depressive disorder. Sixty participants will take either the probiotic or a placebo fo…

This pilot study is testing whether transcranial magnetic stimulation (TMS) can help ease PTSD symptoms in veterans. Twenty veterans with moderate to severe PTSD will receive ten sessions of low-frequency TMS over 2–4 weeks. Researchers will also use brain scans and blood tests t…

This study looks at whether adding a magnesium supplement (magnesium bisglycinate) to standard antidepressant medication can help adults with major depression feel better. About 84 people aged 18-65 who are already on a stable antidepressant will receive either the supplement or …

This study tests whether 2-3 ten-minute visits from a trained therapy dog can reduce pain, anxiety, depression, and anger in adults hospitalized after a traumatic injury. Researchers will compare patients who get dog visits to those who only get a visit from a dog handler. The go…

This study tests a new drug called roluperidone for treating negative symptoms of schizophrenia, like lack of motivation and social withdrawal. About 380 adults with schizophrenia will take the drug or a placebo for 12 weeks to see if symptoms improve. Then, for 40 more weeks, re…

This study tests an experimental drug, icalcaprant, for adults with major depressive disorder who are currently having a depressive episode. About 195 participants will take either the drug or a placebo daily for 6 weeks. Researchers will measure changes in depression symptoms an…

This study tests a 20-25 minute online program called Project EMPOWER-OCD for caregivers of people with OCD. The program teaches caregivers how to reduce accommodating behaviors that can accidentally make OCD worse. Researchers want to see if it lowers caregiver stress and improv…

This study tests a speech therapy program for bilingual Spanish-English or Spanish-Catalan speakers with primary progressive aphasia, a condition that slowly damages language abilities. Sixty participants will receive personalized script training via video sessions, while 30 othe…

This pilot study tests a mindfulness-based music breathing program for older adults (65+) with mild to moderate anxiety or depression. The goal is to see if it boosts resilience and eases symptoms like loneliness and worry. Forty participants will be randomly assigned to the prog…

This study tests whether training mental health professionals to deliver a short psychoeducational program (BREF) can reduce the burden on caregivers of people with schizophrenia or first psychotic episode. The trial will include 206 caregivers, comparing those who receive the pr…

This study tests whether a new drug called TSND-201 can safely reduce PTSD symptoms in adults. About 300 people with PTSD will receive either one of two doses of TSND-201 or a placebo once a week for 4 weeks, then be followed for 8 more weeks. The goal is to see if the drug helps…

This study tests whether immersive virtual reality (VR) can train children with autism, aged 8 to 16, to better process multiple senses at once. Fifty participants will either receive VR training plus usual care or usual care alone. The goal is to see if VR practice helps them fe…

This study compares two ways to treat depression in cancer survivors: a mobile app called Moodivate that tracks activities and mood, and 8 sessions of telehealth therapy with a mental health provider. About 45 adults who have had cancer and currently feel depressed will take part…

This study tests a 6-session program called BE-FIT that helps cardiac rehabilitation patients reduce anxiety about exercise. The program uses gradual exposure to feared sensations, prevents safety behaviors, and uses activity monitors for feedback. Researchers will enroll 146 adu…

This study tests a non-invasive brain stimulation technique called tACS to treat anhedonia (loss of interest or pleasure) in people aged 60 and older with major depression. Eighty participants will receive either real or sham stimulation over two weeks, with follow-up at three mo…

This study looks at whether combining psychotherapy with mind-body practices (like yoga or meditation) helps Veterans with PTSD function better in daily life. About 300 Veterans will be randomly assigned to different types of integrated care for 12 weeks. Researchers will track c…

This study looks at whether having a therapy dog present during a dental visit can lower stress in children. About 225 kids aged 4 to 8 will be randomly assigned to have a dental exam with or without a dog. Researchers will measure stress by tracking heart rate and testing saliva…

This study tests whether adding multi-strain probiotics to the antidepressant sertraline helps teenagers aged 12-18 with major depression feel better than sertraline alone. Over 8 weeks, 120 participants will take either the combination or sertraline with a placebo. Researchers w…

This study looks at whether watching a cartoon or playing a mobile game for 10 minutes before surgery can lower anxiety and fear in children aged 7 to 12 who are hospitalized for appendicitis. About 69 children will be split into three groups: one watches a cartoon, one plays a m…

This study tests whether starting a structured exercise and education program within a month of a pulmonary embolism (a blood clot in the lungs) can prevent long-term problems like poor quality of life, shortness of breath, and reduced physical ability. About 160 hospitalized pat…

This study tests whether a virtual reality mindfulness app can help people with schizophrenia or schizoaffective disorder control impulsive aggression. About 58 participants will use the VR app or do distraction tasks, and have their brain activity measured with fMRI. The goal is…

This study looks at whether a low dose of ketamine, given as an IV infusion, can quickly improve depressive symptoms in adults who have been in the intensive care unit (ICU) for at least 6 days. About 50 participants will receive either ketamine or a placebo on two days in a row.…

This study tests a program called SKILLS that focuses on common factors across different mental health conditions, rather than treating each disorder separately. About 60 adults with stable psychiatric diagnoses will take part. The goal is to see if this approach reduces symptoms…

This study tests whether a non-invasive brain stimulation technique called rTMS can reduce pain and depression in people with fibromyalgia. About 36 adults with chronic pain, some also depressed, will receive either real or sham (fake) rTMS to two brain areas. Researchers will tr…

This study tests a new parent group program for teens aged 12-17 with autism who also have anxiety or depression. The program teaches parents skills to support their teen's mental health. Researchers will see if the program is practical and helpful for families.

This study tests a smartphone app that shares stories from teens who have overcome suicidal thoughts. The goal is to see if these stories help other at-risk teens feel less suicidal and more connected. The study involves 46 adolescents in The Bronx who have had recent suicidal th…

This study is testing a new type of talk therapy called Process-Based Therapy (PBT) for people with anxiety. Unlike standard treatments, PBT adapts techniques from different therapies to target each person's specific struggles. Ten adults with moderate-to-severe anxiety will try …

This study tests a web-based program called TEMPO designed to help men with prostate cancer and their caregivers cope with anxiety and improve physical activity. About 376 patient-caregiver pairs will be randomly assigned to use TEMPO or simply monitor their anxiety for 12 weeks.…

This study tests whether home-based video games can improve speech clarity and arm movement in children with cerebral palsy. Fifteen children aged 8-17 will play specially designed computer games for 30 minutes a day, 5 days a week, for 8 weeks. Researchers will measure changes i…

This study is testing whether a yoga program can help ease depression symptoms in teenagers, compared to group cognitive-behavioral therapy (CBT). Researchers will recruit 96 teens aged 12-18 with elevated depressive symptoms across two sites in Boston and Columbus. Participants …

This study is testing a type of talk therapy for people who have both HIV and PTSD. The therapy helps people understand how trauma affects their emotions and relationships. The goal is to see if this therapy is helpful and acceptable for this group. About 20 adults with HIV and P…

This study tests whether a nasal spray containing dexmedetomidine can quickly reduce symptoms of acute anxiety in adults. 150 participants will receive either the drug or a placebo, and researchers will track anxiety levels over two hours. The goal is to see if the spray is safe …

This study tests an educational support group program for people with progressive aphasia (a language disorder caused by Alzheimer's or other dementias) and their carepartners. The program includes group education, support sessions, and communication skills training. Researchers …

This study tests whether hemp-derived CBD (with or without THC) can help older adults (60+) who use cannabis for pain, anxiety, depression, or sleep problems. Over 8 weeks, 385 participants will take either CBD+THC, CBD alone, or a placebo. The goal is to see if CBD can reduce sy…

This study tests whether a non-invasive brain stimulation technique called tDCS can help adults with Down syndrome who have depression with catatonia (a state of being unresponsive or stuck). 62 participants will receive either real or fake (sham) tDCS for 15 sessions over 5 days…

This study tests whether a 4-week mindfulness group therapy program, added to usual care, can reduce symptoms in 252 young people (ages 16-35) hospitalized for early psychosis. Participants are randomly assigned to either the mindfulness program plus standard treatment or standar…

This study explores whether group drumming or music listening can improve pain, stress, and brain function in people with early Alzheimer's, mild dementia, or mild cognitive impairment, as well as their caregivers. Over 8 weeks, 60 participants will attend weekly sessions while r…

This study looks at mothers who feel severe pain during a C-section despite spinal or epidural anesthesia. It compares giving general anesthesia versus extra pain medicine to see which better prevents post-traumatic stress disorder (PTSD). The goal is to find a way to reduce trau…

This small early study tests whether a gentle brain stimulation technique called temporal interference (TI) can safely reduce PTSD symptoms in 5 adults. Participants will receive TI stimulation and have their brain activity measured with MRI, MEG, and EEG. The goal is to see if s…

This study tests whether a type of talk therapy called Exposure and Response Prevention (ERP) can improve daily functioning and quality of life in veterans with obsessive-compulsive disorder (OCD). About half of the 160 participants also have post-traumatic stress disorder (PTSD)…

This study tests whether combining a brain stimulation technique called rTMS with a computer-based thinking exercise (CBM) can reduce negative thinking and depressive symptoms in people with mild-to-moderate depression. About 180 adults will receive either real or fake rTMS, and …

This study tests whether vortioxetine, an antidepressant known to boost thinking skills, can reduce the mental fogginess caused by the lung cancer drug lorlatinib. About 24 adults with advanced ALK-positive lung cancer who are already taking lorlatinib will receive vortioxetine. …

This study tests whether watching nature scenes through a virtual reality headset or squeezing a stress ball can reduce fear, pain, and anxiety in adults undergoing ureteroscopy (a procedure for kidney stones). 90 participants will be randomly assigned to VR, stress ball, or stan…

This study tests whether a coaching program combined with a decision aid can help Black patients with long-term muscle and joint pain and depression use non-drug treatments like physical therapy or counseling. 304 patients will be randomly assigned to either the coaching program …

This study tests a new medicine called ACP-211 in adults with major depression who haven't gotten better with standard antidepressants. About 153 people will receive either the drug or a placebo for 28 days. The main goal is to see if ACP-211 reduces depression symptoms more than…

This early study tests whether a surgically implanted device that stimulates the vagus nerve can boost the effects of talk therapy for people with chronic PTSD. Twenty adults who have not gotten better with standard treatments will receive either active or sham stimulation alongs…

This study compares two easy relaxation methods—Laura Mitchell's technique and Benson's relaxation response—in 38 adults aged 40–60 with moderate to severe COPD. Participants will practice one of the techniques for 15–20 minutes daily over 6 weeks. The goal is to see which method…

This study tests a short, 3-session program called MERA (Manage Emotions to Reduce Aggression) for veterans with PTSD who struggle with impulsive aggression. The program teaches skills to manage emotions better, with the goal of reducing aggressive outbursts and preparing veteran…

This study tests whether an 8-week online yoga program can improve recovery in lung cancer patients who had lung surgery. Forty participants will either do live yoga sessions three times a week or receive standard care. The goal is to see if tele-yoga boosts exercise capacity, br…

This study tests whether transferring healthy gut bacteria (fecal transplant) through a tube or colonoscopy can reduce autism symptoms in 75 children aged 3-16 with moderate-to-severe autism. Kids continue their usual behavioral therapy. The main goal is to see if autism severity…

This study tests whether real-time fMRI neurofeedback can help teens aged 10-16 with Tourette Syndrome reduce their tics. Participants learn to control activity in a brain region linked to tics by watching their own brain activity on a screen. The trial compares this to a control…

This study tests whether a friendly robot, personalized to each user, can help college students with anxiety complete their cognitive behavioral therapy (CBT) exercises at home. About 140 students with mild to moderate anxiety will use the robot for 6 weeks. The goal is to see if…

This Phase 3 trial tests whether adding seltorexant (a drug that targets sleep) to standard antidepressants can improve mood and sleep in adults with major depression and insomnia who haven't fully responded to their current antidepressant. About 752 participants will receive eit…

This study tests whether a safe, non-invasive brain stimulation technique called tDCS can help reduce certain autism symptoms, like repetitive behaviors and hyperactivity, in children and young adults aged 4 to 17. Researchers will apply a mild electrical current to the cerebellu…

This study tests a new drug called seltorexant for people with major depression who also have trouble sleeping. About 600 adults will receive either the drug or a placebo to see if it improves mood and sleep. The goal is to find a new treatment option that targets both depression…

This study tests whether folinic acid, a form of vitamin B9, can improve autism symptoms in children aged 3 to 10. About 184 children will receive either folinic acid or a placebo for 12 weeks, then all can try the vitamin. The goal is to see if it reduces behavioral and communic…

This study tests a specially adapted early intervention for young Hispanic autistic children (18-42 months) from low-income families. The program, called CLR-Pathways, is delivered by bilingual coaches in the home and focuses on improving social communication and daily skills. Re…

This study adapts a group therapy program called Regulating Together for children aged 8-12 with autism and intellectual disability who struggle with emotions like irritability and aggression. The therapy uses relaxation, mindfulness, and parent training to help kids regulate the…

This study tests whether listening to personalized music enhanced with binaural beats (sound patterns that may influence brain waves) or spatialized (3D-like) audio can reduce behavioral and psychological symptoms of dementia, such as agitation and anxiety. Researchers will enrol…

This study tests if a 12-week cognitive behavioral therapy (CBT) program can help people with paraphilic disorders reduce problematic sexual behaviors and improve their mental health. Researchers will track daily symptoms and interview participants about their experiences. The go…

This study tests a sleep-focused program (TranS-C) plus bright light therapy in 90 teens aged 12-18 with moderate to severe depression and sleep problems. Half get the full program with a sleep therapist and light glasses; the other half just track their sleep. The goal is to see…

This study tests a group-based program called GEARS that teaches emotion regulation skills to adults with ADHD. Researchers will compare 150 participants who receive GEARS to those on a waiting list, measuring changes in emotional control, ADHD symptoms, and quality of life. The …

This study is testing a smartphone app called Vira, combined with health coaching, to help teens aged 12-18 who are dealing with depression and loss of interest in activities. The goal is to see if this approach can increase enjoyment and reduce the risk of suicide. Participants …

This study tests whether having a trained peer mentor—someone who also has atrial fibrillation—can improve mental well-being in patients who are more vulnerable due to low income or education. About 290 participants will either receive usual care or be paired with a mentor for 16…

This study tests a group therapy program called TAG TEAM for trans and gender diverse teens aged 12-17. The program helps them understand and cope with stress from discrimination and rejection. Researchers will compare the program to a waitlist to see if it reduces anxiety, depre…

This study tests if reading a personal narrative book, in addition to standard care, can help women of childbearing age manage anxiety, depression, and negative thinking before a hysterectomy. About 156 women will either receive standard information or also read a book. The goal …

This study looks at whether two different exercise programs can help reduce depression in people with multiple sclerosis (MS) who also have major depressive disorder. Researchers will enroll 146 adults aged 18 to 64. One group will do a structured exercise program, while the othe…

This study tests an experimental drug called evenamide for people with schizophrenia that hasn't improved with standard antipsychotics. About 400 adults will receive either evenamide or a placebo added to their current medication for 12 weeks. The goal is to see if evenamide redu…

This study tests whether the drug KarXT can reduce symptoms of mania in people with Bipolar I disorder who are currently hospitalized for a manic episode. About 274 participants will receive either KarXT or a placebo for 3 weeks while staying in the hospital. The main goal is to …

This study tests a new, non-invasive brain stimulation technique called tTIS in 16 children aged 4-10 with autism. The main goal is to see if it is safe and tolerable. Some children will receive real stimulation and others a sham (fake) version for 5 days. Researchers will track …

This study tests whether a nasal spray containing esketamine, given alongside standard care, can rapidly reduce symptoms of major depression and suicidal thoughts in adolescents. About 258 teens with acute suicidal ideation or behavior will receive either esketamine or a psychoac…

This study tests a workplace-based program designed to help low-wage hospital service workers manage depression and become more physically active. Ten participants will receive remote counseling, work coaching, social needs support, and text message encouragement. The goal is to …

This study tests a computer-based therapy for adults with social anxiety disorder. Researchers want to see if it reduces anxiety and improves quality of life. About 80 people aged 18 to 60 with social anxiety will participate. The therapy is designed to be a new, accessible treat…

This study is testing a wearable device called Sparrow Link that sends gentle electrical pulses to nerves in the ear to help reduce opioid withdrawal symptoms. About 50 hospitalized adults with opioid use disorder will receive either the active device or a sham version, along wit…

This study is testing whether a daily prebiotic fiber powder can reduce stress in healthy adults with mild to severe stress. Over 12 weeks, 120 participants will take either the fiber blend or a placebo. Researchers will measure stress levels, mood, and gut health changes.

This Phase 2 trial tests whether TNX-102 SL, a tablet taken under the tongue at bedtime, can improve depression symptoms in adults with moderate to severe major depressive disorder. About 360 participants will receive either the drug or a placebo nightly for 6 weeks. Researchers …

This study compares group-based Acceptance and Commitment Therapy (ACT) to standard individual therapy for young people aged 16-25 with depression, anxiety, or stress. About 212 participants will be randomly assigned to either group ACT or individual therapy. The goal is to see i…

This study tests whether a single dose of psilocybin, given with psychological support, can improve depression in people with Parkinson's disease. Sixty adults aged 40 to 80 with mild to moderate Parkinson's and depressive symptoms will receive either a low or high dose of psiloc…

This study tests whether a brief, culturally adapted form of behavioral activation therapy, delivered by psychologists in primary care clinics, can reduce depressive symptoms in adults. 96 participants with depression will receive the therapy and be compared to usual care. The st…

This study tests an 8-week social engagement program for seniors who have recently left Adult Protective Services after experiencing elder abuse or self-neglect. The program pairs each senior with a trained student volunteer who makes weekly calls to reduce loneliness and depress…

This study tests whether a single injection of RE104 can reduce symptoms of depression or mixed depression and anxiety in people with adjustment disorder caused by a serious medical illness like cancer, ALS, multiple sclerosis, Parkinson's disease, or idiopathic pulmonary fibrosi…

This study tests an experimental drug called azetukalner in 450 adults with moderate-to-severe major depression. Participants take the drug or a placebo daily for 6 weeks to see if it reduces depression symptoms like low mood and loss of pleasure. The goal is to find a new treatm…

This pilot study tests whether a device called Cereset Research can help caregivers of people with dementia who feel stressed, anxious, or have trouble sleeping. The device plays tones that echo the brain's own rhythms, aiming to improve heart rate variability and reduce stress. …

This study tests whether infliximab, an anti-inflammatory drug used for arthritis, can improve motivation and brain activity in people with schizophrenia who have high inflammation. Sixty adults with schizophrenia will receive either infliximab or a placebo, and researchers will …

This study tests whether low-intensity ultrasound, aimed at the brain, is safe and could help with schizophrenia symptoms. Eighty adults with schizophrenia will receive the non-invasive treatment. Researchers will check safety and look for any improvements in mood, thinking, and …

This pilot study tests whether Tai Chi or exercise can reduce attention problems in college students with ADHD. Researchers will enroll 145 students and measure changes in inattention symptoms. The goal is to see if these non-drug approaches are feasible and worth studying furthe…

This study tests whether adding a nerve block injection (stellate ganglion block) to standard talk therapy (cognitive processing therapy) helps reduce PTSD symptoms more than either treatment alone. About 270 adults with PTSD will be assigned to one of three groups: combination t…

This study tests whether brief cognitive behavioral therapy (CBT) can help people hospitalized for depression or anxiety. About 204 patients will receive CBT sessions during their stay. The goal is to see if this therapy reduces symptoms and improves daily functioning.

This study looks at whether a visual rehabilitation program can ease anxiety and depression in people with advanced age-related macular degeneration (AMD). Twenty-two participants will attend five group sessions over 60 days, learning skills like coin recognition, using voice ass…

This study tests two types of speech therapy for adults with mild-to-moderate primary progressive aphasia, a condition that slowly impairs language. Researchers will compare the therapies in 200 participants to see which better improves communication and reduces caregiver burden.…

This study tests an online program called My Wellbeing Guide for cancer patients who feel depressed or anxious. The program uses videos, activities, and written tips based on cognitive behavioral therapy over 7 weeks. About 6,500 participants will be randomly assigned to the prog…

This study tests a smartphone app called AMP-C that teaches people to notice and enjoy positive events. The goal is to see if it can reduce depression and cannabis use in adults who struggle with both. Eighty participants will either use the app or just track their symptoms. The …

This study tests a new type of transcranial magnetic stimulation called theta burst stimulation (TBS) to see if it can reduce suicidal thoughts in adolescents aged 12-18 with major depressive disorder. Participants receive TBS over 10 days and are followed for one year. The goal …

This study tests whether giving flumazenil, a drug that reverses the effects of benzodiazepines, right before electroconvulsive therapy (ECT) can reduce cognitive side effects like memory loss in hospitalized patients with depression. About 145 participants will either continue t…

This study tests whether a special kind of talk therapy, called Emotion-Focused Acceptance and Commitment Therapy (ACT), can reduce symptoms of Obsessive-Compulsive Disorder (OCD). About 36 adults with OCD will be randomly assigned to either ACT group therapy or a supportive grou…

This study tests whether a text message program that helps people reduce 'safety behaviors' (like checking mirrors or seeking reassurance) can lessen appearance anxiety, body dysmorphic symptoms, and related eating or social anxiety issues. About 300 adults with high appearance c…

This Phase 3 trial tests whether a daily pill called azetukalner can safely reduce depression in people with bipolar I or II disorder. About 400 adults currently in a depressive episode will take either the drug or a placebo for 6 weeks. Researchers will measure mood changes usin…

This study tests whether combining a gentle, non-invasive brain stimulation technique called rTMS with personalized language training can improve language skills in children aged 2 to 5 with global developmental delay. About 50 children will be split into two groups: one gets bot…

This study tests a telemedicine-delivered cognitive behavioral program (RxWell) to help adults with anxiety or depression use fewer opioids after knee or hip replacement. About 150 participants will be enrolled. The program aims to improve mood and reduce painkiller use by provid…

This study tests whether bazedoxifene, a drug that mimics estrogen, can help reduce schizophrenia symptoms in women when added to their usual antipsychotic medication. 160 women aged 18-65 with schizophrenia or related disorders will receive either bazedoxifene or a placebo daily…

This study investigates whether breathing a 50:50 mix of nitrous oxide (laughing gas) and oxygen can reduce pain and anxiety during insertion of a central venous catheter, a common but uncomfortable procedure. Adults aged 18 to 65 who have never used nitrous oxide will be randoml…

This study aims to find differences between organic tics (related to diagnosed disorders) and functional tics (caused by problems in brain-body communication). Researchers will use sensors to measure muscle activity and brain waves in 75 adults with tics and healthy volunteers. P…

This study works with over 126,000 adults and clinic staff to improve how primary care clinics identify and accommodate patients with communication disabilities, such as speech or hearing problems. Researchers will test tools to help clinics record these needs in electronic healt…

This study aims to see if people with major depressive disorder have lower levels of an enzyme called PDE4B in their brains compared to healthy volunteers. Researchers will use PET and MRI scans along with an experimental radioactive tracer to measure this enzyme. The study invol…

This study uses PET scans to measure levels of COX-1 and COX-2, enzymes linked to inflammation, in the brains of people with major depressive disorder (MDD) during a depressive episode. Researchers will compare these levels between MDD participants and healthy volunteers. The goa…

This study investigates how depression and antidepressants influence the way older adults update their beliefs about future events. Researchers compare 31 patients aged 65+ with major depression who are switching antidepressants to 31 healthy volunteers of the same age. Participa…

This study looks at how exercise training impacts blood vessel function in people with PTSD or generalized anxiety disorder, compared to healthy individuals. Researchers want to understand if harmful substances called oxidants play a role in blood vessel damage. The study involve…

This study will carefully examine the physical and mental health of 100 adults admitted to NHS mental health wards. Researchers will review medical notes, do physical exams, and use questionnaires to measure conditions like bipolar disorder, schizophrenia, depression, and persona…

This study looks at whether parents of people with bipolar II disorder or major depressive disorder have certain personality traits (called Type D, which involves negative emotions and social inhibition) and lower life satisfaction. Researchers compare these parents to parents of…

This study looks at whether anxiety or depression makes asthma harder to control and aims to build a model that predicts when a serious asthma attack might happen. Researchers will follow 256 people with asthma for up to two years, tracking their symptoms, mental health, and lung…

This study investigates whether the quality of parent-adolescent communication at the start of psychiatric inpatient treatment predicts how much symptoms improve six months later. Researchers will track 60 adolescents hospitalized for depression, anxiety, or other mental disorder…

This study creates a large registry of people with Rett syndrome, a rare genetic disorder that causes severe intellectual and physical disabilities. Researchers will collect information from doctors and caregivers to understand how the disease progresses over time. The goal is to…

This study aims to understand what happens in the brain when someone thinks about or attempts suicide. Researchers will use brain scans, sleep monitoring, blood tests, and questionnaires to compare four groups: people with recent suicidal thoughts or attempts, those with past sui…

This study looks at how the brains of children with anxiety disorders work differently from healthy children. Researchers will use brain scans and thinking tasks to track changes over a year, before and after standard treatments like therapy or medication. The goal is to find pat…

This study aims to create a risk score that uses information from electronic medical records to predict the chance of developing dementia within 5, 9, or 13 years in older adults with depression. Researchers will analyze data from 44 participants aged 50 and older who have a depr…

This study follows 500 adults already receiving care for depression, bipolar disorder, or suicide risk at the NIH. Researchers will conduct weekly interviews and optional tests like blood draws and brain scans to track symptoms and treatment responses. The goal is to better under…

This study looks at how ongoing stress, anxiety, and poor sleep might affect the course of pancreatic cancer. Researchers will ask 320 participants to fill out simple questionnaires about their mental well-being and will also measure stress markers in leftover blood samples. The …

This study investigates how depression and cannabis use together affect brain circuits involved in reward and pain in young people living with HIV. Researchers will use MRI scans and questionnaires to measure brain activity, mood, and substance use. The goal is to understand why …

This study examines whether a person's personality traits before they got sick are linked to the thinking and behavior problems seen in certain brain disorders. Researchers will ask caregivers about the patient's personality from the 10 years before the illness started. The goal …

This study aims to create a 'patient library' by collecting blood, stool, and hair samples from 250 people aged 15 to 30 who have had a first psychotic episode or are at high risk. Researchers will track their mental health over 10 years using the CAARMS test. The goal is to bett…

This study follows 178 people who had a first episode of psychosis to see how early treatment choices and relapses affect their thinking, daily life, and mental health over 20 years. Participants attend one interview to assess symptoms, thinking skills, and functioning. The goal …

This study gives 25 depressed individuals aged 15-25 a fake version of accelerated transcranial magnetic stimulation (no real brain stimulation). The goal is to see how their beliefs and expectations about treatment change over time and whether those expectations influence mood, …

This study looks at how nicotine changes brain function in people with and without major depressive disorder (MDD). Researchers will give 620 non-smokers either a nicotine patch or a placebo and then scan their brains using MRI. Participants will also answer questions about their…

This study screens up to 5,000 healthy volunteers and people at risk for psychiatric or neurodevelopmental disorders like autism. Participants undergo interviews, cognitive tests, and other evaluations to see if they qualify for future research studies at NIH. The goal is to buil…

This NIH study aims to understand what causes depression in teenagers and how the brain changes with the condition. Researchers will compare depressed teens with healthy ones using interviews, computer tasks, and brain scans. Eligible participants may also receive free talk thera…

This observational study aims to understand why some people are more impulsive or compulsive than others. Researchers will use brain scans, genetic tests, and behavioral surveys in 1,100 participants aged 6 to 80, including those with ADHD, OCD, autism, and conduct disorder. The …

This study looks at how the brain processes emotions by using tiny electrical pulses in people with epilepsy who already have electrodes implanted for surgery. Researchers will measure brain activity and physical responses like sweat to understand how certain brain areas control …

This study at the National Institute of Mental Health screens up to 16,000 people with mood or anxiety disorders, as well as healthy volunteers, to see if they can join other research studies. Participants undergo evaluations like psychiatric interviews, brain scans, and lab test…

This study is observing 400 adults with OCD who are receiving exposure therapy. Researchers will use machine learning to analyze self-reports, behavior, and physiological data from therapy sessions. The goal is to identify which mechanisms lead to better outcomes, so therapy can …

This early study is testing whether adding the drug memantine (used for Alzheimer's) to a standard antidepressant can improve how the brain processes memories in people with major depression. Thirty adults aged 18-50 will take an SSRI for 11 weeks, and for the last 6 weeks they w…

This early-stage study at Stanford tests whether giving magnetic brain stimulation during sleep is safe and practical for people with major depression. Fifteen adults who have not gotten better with at least one antidepressant will receive both real and fake stimulation in separa…

This study aims to learn more about childhood-onset behavioral, psychiatric, and developmental disorders by observing people of all ages who have these conditions, along with their family members. Researchers will collect medical histories, perform psychiatric assessments, and ma…

This study tests whether having a general practitioner and pharmacist work together can help people aged 65 and older safely stop or reduce benzodiazepines (drugs for sleep or anxiety). These medications raise the risk of falls, confusion, and dementia in older adults. The trial …

This study investigates why some adolescents act impulsively when experiencing negative emotions, a trait called negative urgency. Researchers will measure brain cell communication using transcranial magnetic stimulation and EEG in teens aged 13-21 with depression and suicidal th…

This study compares two sets of strategies to help HIV clinics in Cape Town, South Africa, treat depression and improve medication adherence. Ten clinics will be randomly assigned to receive either basic support or enhanced training and supervision. Researchers will track how man…

This study looks at how a stellate ganglion block injection affects sleep in U.S. service members and veterans with PTSD who are already receiving talk therapy. About 40 participants will wear an EEG headband for three nights before and three nights after the injection to measure…

This study from Stanford University is looking at how a 6-week math training program changes brain activity and thinking skills in children with math learning disabilities (dyscalculia). About 180 children aged 6-12 will do math problems on a tablet at home and get weekly one-on-…

This study compares three types of exercise programs—traditional physical activity, virtual reality, and video game-based—to see how they affect physical fitness and attention in healthy adolescents aged 10-18. Participants will be split into three groups and follow their assigne…

This study tests a new idea: that Borderline Personality Disorder (BPD) may be a form of addiction to close relationships, similar to substance use disorders. Researchers will give a special questionnaire to 194 people—those with BPD, those with bipolar disorder, and healthy volu…

This study follows 1,200 families who already have a child with autism (high-risk group) and 500 families from the general population (low-risk group) starting from early pregnancy. Researchers collect biological samples and survey data to explore how genetics, environment, diet,…

This study tests whether spending more than 2 days in a kangaroo mother care (KMC) ward—where mothers hold their low birthweight babies skin-to-skin and get breastfeeding support—can lower the risk of postpartum depression. About 1,900 mothers and their preterm infants in Zambia …

This study is looking at whether test anxiety during final exams is linked to bowel problems and constipation in university students. About 200 students will fill out questionnaires about their anxiety and digestive health. The goal is to better understand how mental stress might…

This study looks at whether giving exposure therapy for OCD at different times in a woman's menstrual cycle changes how well it works. Researchers will use brain scans to see if hormones affect the brain's fear network and OCD symptoms. The goal is to find the best time in the cy…

This study looks at how tiny changes in your RNA (a molecule that reads your DNA) might help predict whether depression treatments will work. Researchers will follow 120 adults with unipolar or bipolar depression to see if these RNA changes match up with improvements in mood. The…

This observational study follows 74 pregnant individuals with severe mental illness to see how taking antipsychotics (versus other medications or no medication) affects psychiatric stability and infant development. Participants complete psychiatric interviews, donate blood, and h…

This study looks at how physical activity, sleep, and light exposure relate to mood in people with bipolar disorder, major depression, or no mood disorder. Over two years, participants wear activity monitors and complete smartphone diaries for up to 20 days at a time. The goal is…

This study tests whether eye-tracking tasks can detect changes in attention and learning in people with Rett syndrome who are starting a new medication called trofinetide. Researchers will compare eye movements and heart rate before and after 4 weeks of treatment in 20 participan…

This study aims to help 25,000 young people aged 12-29 who are at high risk for psychosis reach out for help sooner. Researchers will use online screening and personalized digital messages to encourage them to schedule assessments and connect with local clinics. The goal is to re…

This study is developing and testing a 12-week group education program called FEELS to help Black young adults (ages 18-35) who have experienced trauma better understand mental health and substance use. Participants will attend weekly sessions and complete surveys to see if their…

This study looks at children and teens ages 7-17 who have severe mood problems like chronic anger, sadness, or irritability, along with extreme tantrums. Researchers will use interviews, tests, and brain imaging to understand what happens in the brain. Up to 2,350 participants wi…

This study investigates whether a clinical test using lorazepam (Ativan) and brain imaging can identify veterans with PTSD who might benefit from medications that boost GABA signaling. Researchers aim to validate a computational method to distinguish subgroups of PTSD patients ba…

This study looks at how THC and CBD, two compounds found in cannabis, affect the body's stress response in people who are sleep-deprived and have higher-than-average anxiety. Sixty healthy volunteers will take either THC, CBD, both, or a placebo after a night of restricted sleep.…

This study looks at how mindfulness and fantasizing affect repetitive negative thinking in 100 adults whose depression is in remission. Participants will try both techniques and researchers will measure changes in thinking patterns, heart activity, and brain waves. The goal is to…

This study compares two ways to help adults with mental health issues get follow-up care. One group gets usual care after an emergency room visit, while the other uses a new system that books a psychiatrist appointment within 48 hours through their general doctor. Researchers wil…

This study looks at how using single words or short phrases (instead of full sentences) affects language processing and word learning in young children with autism, ages 1 to 4. Researchers will show children screen-based tasks and track their eye movements to see which type of l…

This study looks at how loneliness impacts recovery from depression in 200 hospitalized patients. Researchers will track symptoms, social support, and collect blood, saliva, and stool samples at three points: start of treatment, discharge, and three months later. The goal is to u…

This study aims to describe moral injury—a deep conflict between professional values and workplace reality—among 3,073 healthcare workers in France. Researchers will use surveys to measure moral injury and identify organizational and personal risk factors. The goal is to guide sy…

This study investigates how the gut and brain communicate in people with Irritable Bowel Syndrome (IBS) who also experience anxiety or depression. Researchers will compare 100 IBS patients with anxiety or depression to 100 healthy volunteers using brain scans, stool samples, and …

This research study examines how brain activity changes during emotional and thinking tasks in people with depression and healthy volunteers. Using brain scans (EEG, fMRI) and mild brain stimulation (TMS), researchers aim to understand the brain circuits involved in mood and suic…

This study looks at how ketamine affects the brain in people with major depression and healthy volunteers. Researchers use brain scans, blood tests, and other measures to understand why a single dose works quickly but briefly. The goal is to find biomarkers that could lead to bet…

This study looks at anxiety levels in 100 living liver donors before and after their surgery. Participants will fill out questionnaires to measure their worry and stress. The goal is to better understand how anxiety affects recovery and to improve care for future donors.

This study looks at how ketamine, a fast-acting antidepressant, affects the brain. Researchers want to understand if a specific brain receptor (AMPA) is key to its effects. Seventy adults with treatment-resistant depression will take part, receiving ketamine and a drug that block…

This study explores whether autistic adults have too much 'plasticity' (flexibility) in the part of the brain that controls movement, and if a non-invasive brain stimulation technique called rTMS can reduce that over-plasticity to improve motor function. Researchers will compare …

This study aims to create a French-language memory task that can be used during brain scans to measure source-monitoring—the ability to remember where information came from. Researchers will test the task on 120 people, including those with schizophrenia and healthy volunteers. T…

This study is testing whether a carbon dioxide (CO2) challenge can predict which patients with anxiety, OCD, PTSD, or panic disorder will not respond to exposure-based therapy. Researchers will enroll 600 adults and measure their reaction to breathing CO2-enriched air before star…

This study looks at whether a tool called the Decision Helper helps people with mental health conditions take a more active role in choosing their treatment. About 62 adults in Danish outpatient mental health clinics will have their consultations recorded and analyzed. The goal i…

This study aims to find out if chronic pelvic pain conditions like prostatitis and interstitial cystitis can be inherited. Researchers will collect DNA and urine from 500 participants, including family members, to look for genetic links. The goal is to better understand the cause…

This study looks at whether women with Ehlers-Danlos syndrome (EDS) experience more severe period pain than those without the condition. Researchers will compare pain levels and other gynecological issues in 156 women using an online questionnaire. The goal is to better understan…

This study tracks 217 people after their first psychotic episode to see if language patterns and blood markers can predict whether they will develop bipolar disorder or schizophrenia. Participants give a recorded interview and blood sample at the start, then are followed for two …

This study looks at how the brain processes time and attention after losing a loved one to suicide, homicide, or accident. Researchers will measure brain waves in 61 adults who experienced such a loss recently. The goal is to find early signs that may lead to PTSD or depression, …

This pilot study will screen 150 homeless adults in French shelters for autism, ADHD, and intellectual disability using interviews and questionnaires. The goal is to find out how many have these conditions, which may have contributed to their homelessness. Results could help tail…

This study looks at whether giving extra money to lower-income parents for three years can improve their children's mental health and brain function. Researchers will follow 500 children, ages 5 to 14 at the start, and measure stress, inflammation, and brain activity using scans.…

This study at Yale investigates how people with OCD process fear and safety signals in the brain. Researchers will use mild electrical stimulation (tDCS) to see if it can improve fear extinction learning, which is key to exposure therapy. 180 adults with OCD will undergo brain sc…

This study looks at how jaw surgery affects speech in people with bite problems like open bite or underbite. Researchers will record patients' speech and tongue movements before and after surgery to see what changes. The goal is to understand why many jaw surgery patients have sp…

This early-stage study involves 18 healthy men to see how well the experimental drug MSP-2020 attaches to serotonin receptors in the brain. Researchers will also measure how much drug stays in the blood and check for side effects. The goal is to understand the drug's activity in …

This study is testing a new, quicker way to diagnose autism in toddlers aged 16-30 months who are already flagged as high risk. Researchers will track how many families are referred, agree to join, and complete the process, including a telehealth option. The goal is to see if thi…

This study uses a special PET scan tracer to measure a brain protein called PDE4B in people with PTSD or alcohol use disorder. Researchers want to see if levels of this protein differ from healthy individuals. The study involves 160 adults aged 18 to 70 and does not offer treatme…

This study looks at brain activity in 100 adults with epilepsy who already have electrodes implanted for seizure monitoring. Researchers will record brain signals while participants answer questionnaires and perform memory and impulse-control tasks. The goal is to find links betw…

This study tests whether a 3-day training program called REFOCUS helps mental health teams provide care that supports personal recovery. About 760 people with severe mental disorders (like schizophrenia or bipolar disorder) will take part across 18 centers. Researchers will measu…

This study looks at the mental health of 200 teenagers aged 12 to 16 who attend special educational institutes (ITEPs) in France. Researchers will use psychiatric interviews to find out how many have conditions like depression or anxiety. The goal is to better understand their ne…

This study aims to find out if a special algorithm can predict which antidepressant will work best for each person with major depression. Researchers will use brain scans, EEGs, and blood tests from 400 adults to see if they can match people to the right medication faster. The go…

This study looks at how depression and very early (preclinical) Alzheimer's disease affect driving habits in adults aged 65 and older who still drive regularly. Participants will have their driving tracked with a GPS device and undergo brain scans to measure Alzheimer-related pro…

This study aims to improve postpartum care for high-risk women in the Mississippi Delta, especially Black women. Researchers will test a community-based program that focuses on building trust, improving health literacy, and strengthening family support. The goal is to reduce seve…

This study will follow 1,200 people with schizophrenia in Shanghai for up to 5 years. Researchers will track symptoms, aggression, and other mental health changes to understand how the disease progresses. The goal is to build a long-term database and biobank to improve future car…

This study tests whether a gentle brain stimulation technique called tDCS, done at home, can improve sleep quality in adults with moderate depression. Researchers will track sleep changes and see if better sleep leads to better mood. The study involves 35 participants and aims to…

This study explores the connection between anxiety and frailty in people aged 65 and older who are about to have hip replacement surgery. Researchers will measure anxiety and frailty using standard questionnaires before the operation. The goal is to understand how these factors r…

This observational study follows up to 2,000 people with Williams syndrome or related chromosome changes, along with their family members. Researchers will track health, development, behavior, and quality of life from childhood through adulthood. They are also building a biobank …

This study aims to improve MRI imaging methods to better understand how mood and anxiety disorders affect the brain. Researchers will scan healthy volunteers and people with major depressive disorder while they perform tasks or view images. The goal is to refine these techniques …

This study tests a technique called real-time fMRI neurofeedback, where people with depression learn to control brain activity by watching a visual pattern change in real time during an MRI scan. Researchers want to see if this can help regulate brain networks linked to depressio…

This study tests a non-invasive brain stimulation technique called tDCS for depression. Researchers use MRI scans to see how the stimulation affects brain networks. 144 adults with depression will receive either real or sham tDCS while performing a memory task. The goal is to fin…

This study compares two strategies for teaching new words to autistic children aged 4 to 10: repeating words (re-study) versus quizzing after labeling (repeated quizzing). Researchers want to see which method helps children learn nouns and adjectives better and whether they can u…

This study looks at whether simple, painless tests of eye movements and heart rate can help predict which children with ADHD will benefit from medication and which will have side effects. Researchers will measure these factors before children start medication and then check how w…

This study examines whether climate anxiety is linked to suicidal thoughts and behaviors in young people aged 16 to 24 who are receiving psychiatric care. Researchers will use questionnaires to measure climate anxiety, general anxiety, and suicide risk in 108 participants. The go…

This study looks at facial features of males aged 2 to 40 with creatine transporter deficiency (CTD), a genetic disorder that causes intellectual disability, seizures, and behavioral issues. Researchers will examine photos of participants to see if they share common facial traits…

This study tests whether real-time brain scans (fMRI) can help young adults with anxiety learn to regulate their emotions better. Participants will practice reappraising negative thoughts while seeing their own brain activity. The goal is to understand which brain areas are invol…

This study compares 240 people with paraphilic disorders, compulsive sexual behavior, or sexsomnia to healthy controls. Researchers will assess violence history, psychiatric traits, and genetic factors through interviews, questionnaires, and blood samples. The clinical group will…

This study follows 80 cervical cancer patients who receive brachytherapy (internal radiation) to see if they develop post-traumatic stress disorder (PTSD). Participants fill out questionnaires about PTSD, anxiety, depression, quality of life, and sexual health over 5 years. The g…

This study aims to improve suicide prevention for people who move between healthcare and the criminal-legal system. Researchers will link health records, Medicaid data, and jail booking information to identify individuals at risk and coordinate care. Over 1,000 adults with past p…

This study looks at whether a simple rating scale used by doctors right after a traumatic event can predict who will develop post-traumatic stress disorder (PTSD) later. Researchers will follow 241 adults who experienced a trauma in the last 48 hours, tracking their scores and ch…

This study looks at brain activity during sleep in people with early-course schizophrenia compared to healthy individuals. Researchers will play soft tones during deep sleep using a wearable headband to see if it can strengthen sleep-related brain waves and improve memory. The go…

This study looks at how the brain naturally reduces pain signals and whether that ability affects how well a lumbar medial branch block (a common injection for back pain) works. Researchers will test 40 adults with chronic low back pain using heat, pressure, and other sensations …

This study adapts PlayReadVIP, a program that coaches parents on positive interactions during reading and play, for use in family child care homes. Researchers will enroll 240 providers to see if the program improves provider confidence and children's literacy behaviors. The goal…

This study follows 50 children and adults with Baker Gordon Syndrome, a rare genetic disorder, to track how the condition changes over time. Participants will undergo brain scans, EEGs, and genetic testing, and complete developmental assessments. The goal is to create better tool…

This study is testing whether subtle changes in how people speak can predict who will develop schizophrenia. Researchers will record and analyze free speech from 215 young people aged 15-30 who are at ultra-high risk for psychosis. By using computer programs to detect semantic an…

This study looks at whether a single session of a brain stimulation technique called rTMS can change heart activity in women who have had multiple pregnancy losses and also have anxiety. Forty-six women will receive either real or fake stimulation while their heart rate is monito…

This study explores whether a non-invasive brain stimulation technique called rTMS can reduce cannabis cravings in people with schizophrenia or schizoaffective disorder. Researchers will compare brain activity changes in 100 participants, including healthy cannabis users. The goa…

This study is looking at how environmental factors in cities—like air pollution, noise, and lack of green space—affect people with depression, anxiety, or alcohol use disorder. Researchers will have 680 participants wear smartwatches to track heart rate, activity, and other body …

This early-stage study tests a brain implant called BrainGate in just 3 people with severe paralysis or speech loss from conditions like ALS or spinal cord injury. The goal is to see if the device is safe and can let users control a computer cursor or other tools by thought alone…