Magic mushroom compound tested for back pain and depression

NCT ID NCT06355414

First seen Nov 01, 2025

Summary

This study looks at how psilocybin (the active ingredient in magic mushrooms) affects mood and pain in people with both chronic low back pain and depression. About 40 adults will receive either a single high dose of psilocybin or a control drug. Researchers will track changes in positive and negative emotions, pain-related thoughts, and pain sensitivity over one month.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Johns Hopkins University School of Medicine

    RECRUITING

    Baltimore, Maryland, 21224, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

    Contact

Conditions

The condition(s) this trial relates to.

Depression depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.