CHRONIC LOW BACK PAIN

This study is testing a new artificial disc implant for people with chronic low back pain from degenerative disc disease. About 72 adults who have not gotten relief from at least 6 months of other treatments will receive the implant. The goal is to see if the device safely reduce…

This study tests whether a mobile app and headset can help people with chronic low back pain by training their brain to relax. About 150 adults with long-term back pain will use the app for 10 minutes, four times a week for three months. Researchers will check pain levels and dai…

This pilot study tests whether ketamine infusions followed by a brief behavioral program can help veterans with chronic low back pain and depression. The goal is to see if the approach is safe, acceptable, and practical. About 44 veterans will take part.

This study looks at whether a high-frequency electrical current (called TECAR) can reduce pain and improve movement in people with muscle injuries or low back pain. About 200 adults with muscle strains or back pain will receive either the treatment or a control. Researchers will …

This study is tracking how well a commercially approved procedure called Intracept works for people with chronic low back pain caused by a condition called vertebrogenic pain. The procedure uses a small device to treat the painful nerve inside the spine bone. Researchers will mea…

This study aims to find the best non-surgical, non-drug treatments for chronic low back pain in Veterans. About 2,500 Veterans will be randomly assigned to different treatments, including online pain self-management, enhanced physical therapy, yoga, spinal manipulation, or cognit…

This study is testing whether adding osteopathic treatment (a type of hands-on therapy) to standard medical care can reduce pain in people with chronic low back pain that has lasted more than 3 months. About 199 adults will be randomly assigned to receive either standard care alo…

This study is testing several experimental treatments to ease chronic pain from knee arthritis, diabetic nerve pain, or ongoing low-back pain. Researchers will compare each treatment against a placebo to see which ones work best. The trial aims to enroll 10,000 adults who have ha…

This study tests whether a gentle, non-invasive brain stimulation technique called tACS can reduce chronic low back pain. Researchers will measure pain levels and brain activity in 80 adults aged 18-60 who have had low back pain for over 6 months. The goal is to see if tACS can c…

This study will compare physical therapy done through video visits (telerehabilitation) with in-person clinic visits for people with chronic low back pain. Researchers will enroll 1000 adults in Maryland and Utah who have had low back pain for at least 3 months. The goal is to se…

This study looks at whether adding biofeedback to standard back exercises can reduce pain and improve balance and daily function in people with chronic low back pain. About 110 adults aged 30-65 with ongoing pain will be randomly assigned to receive either standard therapy or the…

This study is testing if a non-invasive device that sends mild electrical pulses through the skin to the spinal cord can help people with chronic low back pain. The goal is to see if it can reduce pain and improve movement, like standing up from a chair. The study will enroll 50 …

This study compares usual physiotherapy with a personalized approach called STOPS for people with chronic low-back pain. Researchers want to see if STOPS reduces pain and disability better and if it is cost-effective. About 154 patients and their physiotherapists in Bangladesh wi…

This study tests whether adding supervised group art therapy to exercise can help older adults (60+) with chronic low back pain feel better physically and emotionally. Thirty participants will try the program and report on pain, mood, and daily function. The main goal is to see i…

This study tests whether mindfulness meditation can reduce chronic low back pain in adults aged 50 and older. Researchers will track pain levels and explore how the gut-brain connection plays a role. 66 participants will practice meditation for 8 weeks, and the goal is to see if …

This study compares two treatments for chronic low back pain: a hands-on therapy called thoracolumbar fascia mobilization and an injection of a sugar-water solution (5% dextrose) guided by ultrasound. The goal is to see which approach better reduces pain, improves movement, and e…

This study tests whether adding a weight loss program (diet, exercise, and behavior changes) to standard back pain treatment helps overweight or obese people with chronic low back pain. About 252 adults will be split into two groups: one gets standard care, the other gets standar…

This study tests a new medicine called CELZ-201-DDT, given as a shot into the back muscles, for people with long-term lower back pain caused by worn-out discs. The goal is to see if it is safe and can reduce pain and improve movement. About 45 adults aged 18-80 who have not gotte…

This study tests whether adding shock wave therapy to usual treatments (like exercise and physical therapy) can better reduce pain and disability in people with chronic low back pain. About 44 adults with pain lasting over three months will receive either standard care alone or s…

This study compares a new type of needle used in a standard pain-relief procedure (radiofrequency ablation) against usual medical care for people with chronic low back pain. About 50 adults with pain lasting at least 6 months will be enrolled. The goal is to see if the new needle…

This study looks at whether a single high dose of psilocybin (the active ingredient in magic mushrooms) can help people with both chronic low back pain and depression. About 40 adults will receive either psilocybin or a control drug, and researchers will track changes in mood, pa…

This study tests a new type of spinal cord stimulation (called TVP-SCS) in 70 adults with long-term back and leg pain that hasn't responded to other treatments. The goal is to see if this approach can reduce pain by at least 50% after 3 months. Participants will use a commerciall…

This study tests whether a telehealth physical therapy program can help people with chronic low back pain who live in rural areas. Many rural patients can't get to in-person therapy due to distance or time off work. The program matches each person to the right type of virtual the…

This study compares virtual reality-based rehabilitation to standard physical therapy for 80 adults aged 40-65 with chronic low back pain lasting at least three months. Participants will do exercises with a 3D camera and real-time feedback or stick to conventional therapy for fou…

This study compares two treatments for adults aged 20-65 with chronic low back pain lasting at least a year: lumbar fusion surgery versus a multidisciplinary rehab program. The goal is to see which approach better reduces disability and improves daily life. Participants are rando…

This study is for adults aged 50 to 85 with chronic low back pain and mild to moderate depression. Participants will practice mindfulness meditation at home while using a small device that gently stimulates a nerve in the ear. The goal is to see if this combination can reduce pai…

This study tests whether active music-making can improve thinking, reduce pain sensitivity, and boost quality of life in people with chronic low back pain. Forty adults aged 18-65 with persistent low back pain will attend five sessions over two weeks. Researchers will measure cha…

This study looks at whether brain scans can help predict which people with long-term low back pain will respond well to spinal cord stimulation (SCS). Researchers will scan the brains of 42 adults before they receive SCS as part of their normal care, then check their pain levels …

This study uses a smartphone app called SOMA to track daily mood, pain, and activity in 800 people with acute or chronic pain, as well as healthy volunteers, over four months. The goal is to find patterns that predict whether pain becomes long-term, improves, or flares up. A smal…

This study aims to improve how doctors diagnose and treat chronic musculoskeletal pain (lasting over 12 weeks) from conditions like arthritis, fibromyalgia, and low back pain. Researchers will test a simple questionnaire and pain sensitivity assessments to see if they can identif…

This study tests a new disposable wearable activity monitor called VERABAND™ in people with chronic low back pain. Researchers want to see if doctors find it easy to use and if they would adopt it in their clinics. About 360 clinicians and patients will take part at multiple pain…

This study looks at whether brain wave tests (EEG) can help predict how chronic low back pain changes over time. Researchers will track 130 adults with chronic low back pain and healthy volunteers for 5 months, measuring brain activity and pain levels. The goal is to find brain m…

This study looks at how a device that delivers a cold puff to the ear might help people with long-term low back pain. Researchers will use brain scans to see if this treatment changes how the brain processes pain. The study involves 60 adults who have had back pain for at least 6…

This study looks at how spinal cord stimulators affect the brains of 20 adults with chronic low back pain. Researchers will use fMRI scans to compare brain activity when the stimulator is on versus off. The goal is to find patterns that predict who will benefit most from this tre…

This study aims to use ultrasound imaging and machine learning to better understand low back pain by looking at a layer of tissue called the thoracolumbar fascia. Researchers will compare images from people with acute, chronic, or no back pain. They will also test two treatments—…

This study looks at what motivates or prevents people with chronic low back pain from using a health app to stay physically active. Researchers will interview 25 patients to understand their needs and challenges. The goal is to design better digital tools that help patients maint…