CHRONIC LOW BACK PAIN

This study tested a device called ReActiv8 that uses mild electrical pulses to stimulate back muscles in people with long-term low-back pain. 203 adults who had not found relief from medication or physical therapy were randomly assigned to receive either the device or standard me…

This early-stage study tested an investigational drug called PP353 in 43 adults with chronic low back pain linked to a specific type of spine bone change (Modic 1). The main goals were to check safety and see if the drug reduces pain better than a placebo. Participants had to hav…

This study tested a new medicine called HCP1004 against an existing one (RLD2401) in 310 adults with chronic low-back pain lasting at least 3 months. The goal was to see if the new drug works just as well and is safe. Participants rated their pain on a scale, and researchers also…

This study tested a biofeedback device that uses muscle sensors and a smartphone app to help people with chronic low back pain, pain after breast surgery, or migraines learn to relax tense muscles. About 330 adults were randomly assigned to use the device or receive usual care. T…

This study tested whether a non-invasive brain stimulation technique (repetitive transcranial magnetic stimulation) alone or combined with specific exercises could reduce pain and improve daily function in people with chronic low back pain. 140 adults with long-lasting back pain …

This study tested whether adding cupping therapy to standard physiotherapy reduces pain and improves daily function in people with chronic low back pain. 48 adults received either real dry cupping or a sham (fake) cupping, both alongside routine physiotherapy. The goal was to see…

This study looked at whether custom-made foot orthoses (shoe inserts) can reduce chronic low back pain in adults with pronated (flat) feet. 110 participants wore either custom orthoses or placebo inserts. The goal was to see if correcting foot position could improve pain and dail…

This study tested a new approach for people with long-term low back pain. Participants received a one-hour session on how pain works, followed by 30 minutes of exercise using virtual reality. The goal was to see if this combination could reduce pain intensity, improve movement, a…

This study looked at two different ways to help people with long-term low back pain: a pressure technique called ischemic compression and a special tape called kinesiology taping. Over 100 adults with back pain for at least 12 weeks took part. The goal was to see if adding these …

This study tested a mobile app called SleepFix that delivers behavioral therapy for insomnia in 106 adults with chronic low back pain and poor sleep. The goal was to see if using the app for 3 weeks could reduce how much pain interferes with daily life after 6 weeks. Participants…

This early-stage study tested whether an experimental oral drug called PIPE-791 is safe and can reduce pain in adults with long-term osteoarthritis knee pain or chronic low back pain. 43 participants stopped their usual pain medicines, then took either the study drug or a placebo…

This study tested if prolotherapy (a sugar-water injection) can ease chronic low back pain caused by arthritis in the facet joints of the spine. Sixty adults aged 40-70 with long-lasting back pain were randomly given either prolotherapy, a steroid shot, or a saltwater placebo. Re…

This study tested a special breathing program called Guided Respiration Mindfulness Therapy for adults with chronic low back pain. Nineteen people took part in eight weekly one-hour sessions where they practiced a continuous breathing pattern while relaxing and accepting body sen…

This study looked at 131 people who still had low back pain after spinal surgery. It compared a procedure called pulsed radiofrequency (with or without steroids) to standard steroid injections. The goal was to see which treatment reduces pain and improves daily function better. R…

This study tested whether teaching people with chronic low back pain about how pain works in the brain and body (pain neuroscience education) reduces disability better than standard education about spine anatomy. 88 adults with back pain for over a year took part. The goal was to…

This study looked at whether a specific type of exercise called dynamic neuromuscular stabilization can help people who have had low back pain for at least six months. Twenty adults took part, and researchers measured their pain, posture, and quality of life before and after the …

This study tested whether a multidisciplinary biopsychosocial program (a team of experts addressing physical, emotional, and social factors) works better than standard multimodal care for chronic low back pain. 128 adults participated over 4 weeks. The goal was to reduce pain, di…

This study tested a web-based hypnosis app called Rose in 100 adults with chronic pain (including low back pain) over 8 weeks. Participants used the app and reported on pain, satisfaction, and usability. The goal was to see if the app is user-friendly and effective at reducing pa…

This study tested whether antidepressants, physical therapy, or a combination of both can help people with chronic low back pain who also struggle with negative emotions. Researchers measured improvements in pain, daily function, and depression. The goal was to find better ways t…

This study tested a procedure called epiduroscopic adhesiolysis in 141 people with chronic back and leg pain. Half had prior back surgery that failed, and half had no surgery. The procedure uses a tiny camera to see inside the spine and gently break up scar tissue, which can reli…

This study looked at whether acupuncture helps older adults (65 and older) with long-term low back pain feel better and move easier. Over 800 people took part, receiving either their usual care or acupuncture sessions over several months. The goal was to see if acupuncture reduce…

This pilot study tested two behavioral programs—mindfulness and education—delivered via telehealth to 67 adults recovering from lumbar spine surgery. Participants attended 8 weekly online sessions and completed surveys and pain tasks before surgery and at 2 weeks, 3 months, and 6…

This study tested whether using virtual reality (VR) at home can help people with chronic low back pain feel better and move more. Over 400 adults with back pain for at least 3 months were randomly assigned to one of three VR programs: one teaching pain-coping skills, one providi…

This study tested whether using virtual reality to guide acupuncture imagery can help people with chronic low back pain. 31 adults with pain lasting over 6 months took part. The goal was to see if the treatment was easy to stick with, safe, and satisfying.

This study tested whether teaching people about pain during light cycling helps chronic low back pain more than cycling alone. 24 adults with long-term back pain took part. Both groups cycled, but one group also learned about how pain works. The goal was to see if combining educa…

This study tested whether a drug called propranolol (normally used for heart conditions) combined with pain education could help adults with chronic low-back pain or fibromyalgia. 48 participants were enrolled to see if the approach was feasible and acceptable, and to get early d…

This study followed 89 adults with chronic low back pain who joined a rehabilitation program. Researchers wanted to see if the program helped them become more physically active, sit less, and change their motivation for exercise. The goal was to understand what drives these behav…

This pilot study looked at how people with chronic low back pain walk and whether a distraction task could change their walking pattern and reduce pain. 16 adults with long-term back pain walked at their normal speed and a faster speed, with and without a distraction. The goal wa…

This completed study looked at nearly 500 people with chronic low back pain to understand why some treatments work better for certain individuals. Participants tried one of four approaches—mindfulness, physical therapy, acupressure, or medication—and those who didn't improve enou…

This study enrolled 800 adults with new or ongoing neck or low back pain to find new biological and imaging markers. Researchers used X-rays and MRIs to look at spine changes and questionnaires to track disability. The goal was to better understand how pain develops and improve f…

This study compared movement stability between 70 people with chronic low back pain and healthy volunteers matched by age, sex, and body size. Researchers measured how steady participants' movements were during bending and twisting tasks. The goal was to understand how long-term …