CHRONIC LOW-BACK PAIN

This study tested an implanted device called ReActiv8 against standard medical care for chronic low-back pain. 203 adults with long-lasting pain that didn't improve with other treatments took part. The device aims to stimulate back muscles to reduce pain and improve function.

This study investigates whether adding emotion regulation training to physical activity can improve outcomes for people with chronic low back pain. Participants attend twice-weekly sessions for 12 weeks, combining gentle exercise with techniques to better manage emotions. The goa…

This study tested a new treatment called Localized Tissue Hydration for people with chronic low back pain. The treatment was added to standard care for 30 adults. The main goal was to see if it could reduce pain by at least 30% after 6 months.

This study looked at 252 adults with chronic low back pain to find the best volume and dose of local anesthetic when combined with a steroid in epidural injections. Participants received one of four dosing combinations over three injections in 12 months. Researchers measured pain…

This study tested whether using a special PET/CT scan to guide injections into the spine joints works better than the usual ultrasound method for people with long-term low back pain. Forty adults who did not get relief from standard treatments received a steroid and numbing medic…

This study tested whether an online therapy program (acceptance and commitment therapy) combined with back exercises helps older adults with chronic low back pain. Fifty participants were split into two groups: one received online therapy plus exercises, the other received online…

This study tested whether a single injection of platelet-rich plasma (PRP) into the spinal disc could reduce pain and improve function in people with chronic low back pain caused by active discopathy. 126 adults aged 18 to 60 with at least 3 months of pain received either PRP or …

This study looked at whether a specific type of exercise called dynamic neuromuscular stabilization can help people with chronic low back pain. Twenty adults with pain lasting at least six months took part. Researchers measured changes in pain, posture, daily function, and qualit…

This study tested whether injecting a sugar solution (dextrose) into the small joints of the lower back can reduce pain and improve function in people with chronic low back pain. Sixty adults aged 40-70 with facet joint arthritis were randomly assigned to receive dextrose, steroi…

This study tested a special breathing program called Guided Respiration Mindfulness Therapy for adults with chronic low back pain. Nineteen people took part in 8 weekly one-on-one breathing sessions. The goal was to see if the therapy is practical, acceptable, and might help redu…

This study tested an experimental drug called PP353 in 43 adults with long-term low back pain linked to a specific type of bone marrow change (Modic 1) seen on MRI. The main goals were to check safety and see if the drug reduces pain better than a placebo. Participants rated thei…

This early-stage study tested whether an experimental pill called PIPE-791 is safe and can lower pain in adults with long-term osteoarthritis knee pain or chronic low back pain. 43 participants stopped their usual pain meds, then took either the study drug or a placebo daily for …

This study tested whether teaching people about pain during light cycling helps chronic low back pain more than cycling alone. 24 adults with long-term back pain were split into two groups: one cycled while learning about pain, the other just cycled. Researchers measured pain, pr…

This study tested whether adding kinesiology taping or ischemic compression to standard physiotherapy helps people with chronic low back pain. 102 adults with back pain for at least 12 weeks were split into three groups. Over three weeks, researchers measured changes in pain and …

This study looked at a procedure called epiduroscopic adhesiolysis, which uses a tiny camera to see inside the spine and break up scar tissue, for people with long-term back and leg pain. Researchers compared results in 141 adults who had prior back surgery and those who did not.…

This study tested whether a multidisciplinary biopsychosocial program—combining physical, psychological, and social support—works better than standard multimodal treatment for people with chronic low back pain. 128 adults aged 18-65 took part over four weeks. Researchers measured…

This pilot study tested whether online mindfulness sessions could help people recover better after lumbar spine surgery. 67 adults who had their first back surgery were randomly assigned to either mindfulness training or education sessions over 8 weeks. The main goal was to see i…

This study tested a device that uses muscle sensors and a phone app to teach people how to relax tense muscles. It included 330 adults with chronic low back pain, recent breast surgery pain, or migraines. Half used the device plus usual care; the other half had only usual care. T…

This study tested a new approach for chronic low back pain that combines a one-hour pain education session, 30 minutes of virtual reality exercise, and standard therapeutic exercise. Forty adults with chronic low back pain participated. The goal was to see if this combination cou…

This study tested whether watching a virtual reality (VR) video of acupuncture needles being applied could help people with chronic low back pain. 31 adults with pain lasting over 6 months participated. The goal was to see if people would stick with the treatment and find it sati…

This study looked at whether an antidepressant, physical therapy, or a combination of both can help people with chronic low back pain who also struggle with negative feelings. About 308 adults aged 18-75 with pain lasting over 6 months took part. The goal was to see if these trea…

This study tested whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS), alone or combined with specific exercises, can reduce pain and disability in people with chronic low back pain. 140 adults with long-lasting back pain …

This study tested whether acupuncture helps reduce disability from chronic low back pain in adults aged 65 and older. Over 800 participants received either standard acupuncture (up to 15 sessions in 3 months), enhanced acupuncture (additional sessions over 6 months), or usual car…

This study tested a web app called Rose that provides hypnosis audio recordings for people with chronic pain. 100 adults with chronic low back pain or other chronic pain used the app for 8 weeks. The researchers measured how often people used it, their satisfaction, and changes i…

This study tested whether teaching people with chronic low back pain about how pain works in the brain and body (pain neuroscience education) helps them move better and feel less disabled compared to standard education about spine anatomy. 88 adults with back pain for over a year…

This completed Phase 3 study tested a new drug called HCP1004 against an existing painkiller (RLD2401) in 310 adults with chronic low-back pain lasting at least 3 months. The goal was to see if HCP1004 works just as well for pain and function, while monitoring safety. Participant…

This study tested a mobile app called SleepFix that helps people with chronic low back pain and insomnia improve their sleep. Over 100 adults used either the app or received sleep education for 3 weeks. The goal was to see if better sleep could reduce how much pain interferes wit…

This study tested whether using virtual reality (VR) at home can help people with long-term low back pain feel better and move more. Over 400 participants used one of three VR programs (skills-based, distraction, or sham) along with a Fitbit to track activity. The goal was to see…

This study tested a new approach for chronic low-back pain and fibromyalgia in 48 adults. Participants received pain education plus propranolol (a blood pressure drug) to help the brain 'relearn' and reduce pain. The goal was to see if the treatment is feasible and acceptable, an…

This study tested whether custom-made foot orthoses (shoe inserts) can reduce chronic low back pain in adults with pronated (flat) feet. 110 participants were randomly assigned to wear either custom orthoses or flat insoles for a period. Researchers measured pain levels and disab…

This study tested two treatments for people with ongoing back pain after spinal surgery: pulsed radiofrequency (a procedure using mild electrical pulses) and a standard steroid injection. About 130 patients were followed for several months to see which approach reduced pain and i…

This study tested whether dry cupping therapy, combined with routine physiotherapy, helps people with chronic non-specific low back pain more than a sham (fake) cupping treatment. Forty-eight adults with pain lasting at least 3 months took part. The results showed that real cuppi…

This study looked at whether people with chronic low back pain can correctly identify the source of their pain after learning about common causes. About 288 adults with back pain for over 3 months reviewed educational slides and then guessed their top two diagnoses. Researchers c…

This completed study enrolled 800 adults with chronic neck or low back pain to identify new biological and imaging markers. Researchers used X-rays, MRIs, and questionnaires to track pain and spine changes over time. The goal is to better understand how acute pain becomes chronic…

This study looked at 89 adults with chronic low back pain who went through a rehabilitation program. Researchers measured their physical activity, sitting time, and motivation before and after the program. The goal was to see if the program helped patients become more active and …

This completed study with 494 participants looked at how different treatments for chronic low back pain work and who benefits most. Participants first tried an online pain management program, then those who didn't improve much were randomly assigned to mindfulness, physical thera…

This pilot study looked at how distraction (like listening to something) changes walking patterns and pain in people with chronic low back pain. Sixteen participants walked on a treadmill at different speeds, with and without distraction. The goal was to see if distraction could …

This study looked at how chronic low back pain changes the way people control their movements. Researchers compared 70 participants—some with long-term back pain and some healthy—by measuring their stability during bending and twisting motions. The goal was to better understand t…