CHRONIC LOW-BACK PAIN

This study will follow 80 people with chronic pain (like back, hip, or nerve pain) who are getting a procedure called cryoneurolysis, which uses cold to temporarily block pain signals. Researchers want to see if it leads to meaningful pain relief and better daily function over 12…

This Phase 3 trial tests whether combining transcranial magnetic stimulation (TMS) with yoga can ease chronic low back pain in 213 veterans. TMS uses magnetic pulses to gently stimulate brain areas involved in pain, while yoga adds stretching and strengthening. The goal is to red…

This study tests two natural brain molecules as a safe, non-addictive treatment for chronic low back pain in 108 U.S. military veterans aged 18-65. The goal is to reduce pain severity and improve daily function without the risks of opioids. Participants will receive the experimen…

This study tests whether cognitive functional therapy (CFT) can reduce disability in people with chronic low back pain after spinal surgery. 90 adults aged 18-75 who have had surgery at least 3 months ago and still have pain will receive either CFT or a sham treatment. The main g…

This study tests whether a smartphone app that provides personalized exercises, pain management audio, and coaching can reduce activity limitations in adults with chronic low back pain. 330 participants will either use the app or continue usual care. The main goal is to see if th…

This study looks at whether adding connective tissue massage to exercise can reduce pain and improve movement, balance, and quality of life in people with chronic low back pain. About 40 adults aged 18-65 with back pain for at least 6 months will receive either real massage or a …

This pilot study will test whether the Neurolumen device—which combines low-level lasers, LEDs, and electrical stimulation—can reduce pain and painkiller use in 50 adults with chronic low back pain. Participants will use the device daily for 4 weeks, and some will receive a sham …

This study tests whether thread-embedding acupuncture, which uses absorbable threads to provide ongoing stimulation, can reduce disability and improve flexibility in people with chronic low back pain. 32 adults will be randomly assigned to receive either the real treatment or a s…

This study will test whether adding pain neuroscience education (learning how pain works) to standard back exercises helps people with chronic low back pain more than exercises alone. Forty adults aged 25 to 50 with pain lasting over 12 weeks will be randomly assigned to either e…

This study will test three types of physical therapy for chronic low back pain: active exercises in water, passive movements guided by a therapist in water, and standard exercises on land. Twelve adults aged 18 to 65 with pain lasting over three months will participate. The goal …

This study will test whether combining Pilates with resistance training can reduce pain, disability, and sleep problems in people with chronic low back pain. 110 participants will be split into three groups: one doing both Pilates and resistance training, one doing Pilates alone,…

This study tests whether adding a daily physical activity program to a structured exercise routine can reduce disability and improve mental health in people aged 60 and older with chronic low back pain. One hundred participants will be split into three groups: exercise plus activ…

This study looks at how leisure activities—like hobbies, social outings, or exercise—impact the quality of life of 148 adults with chronic low back pain. Researchers will use questionnaires to measure activity levels and well-being. The goal is to understand if staying active in …

This study will check if a virtual reality version of a common mobility test (the Timed Up and Go test) works well for people with chronic low back pain. About 65 adults aged 18 to 55 will do both the standard test and a VR version, then repeat the VR test a week later. The goal …