New drug targets spine pain from bone marrow lesions
NCT ID NCT04238676
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested an experimental drug called PP353 in 43 adults with long-term low back pain linked to a specific type of bone marrow change (Modic 1) seen on MRI. The main goals were to check safety and see if the drug reduces pain better than a placebo. Participants rated their pain on a 0-10 scale, and researchers also tracked daily function.
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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CGM Research Trust
Christchurch, 8083, New Zealand
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Gildhøj Privathospital København
Copenhagen, 2605 Brøndby, Denmark
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Hospital Universitario LA PAZ
Madrid, Spain
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Hospital Vithas Granada
Granada, Spain
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Leeds General Infirmary
Leeds, LS1 3EX, United Kingdom
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Oxford University Hospitals NHS Foundation Trust
Oxford, Oxford, OX3 9DU, United Kingdom
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Royal Preston Hospital
Preston, Lancashire, PR2 9HT, United Kingdom
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University Hospital Coventry & Warwickshire
Coventry, CV2 2DX, United Kingdom
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University Hospital Of Wales
Cardiff, Wales, CF14 4XW, United Kingdom
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University Hospital Southampton Nhs Foundation Trust
Southampton, SO16 6YD, United Kingdom