New drug targets spine pain from bone marrow lesions

NCT ID NCT04238676

Completed Symptom relief Sponsor: Persica Pharmaceuticals Ltd Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested an experimental drug called PP353 in 43 adults with long-term low back pain linked to a specific type of bone marrow change (Modic 1) seen on MRI. The main goals were to check safety and see if the drug reduces pain better than a placebo. Participants rated their pain on a 0-10 scale, and researchers also tracked daily function.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for CHRONIC LOW-BACK PAIN are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

Back Pain Low Back Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC LOW-BACK PAIN

Contacts and locations

Locations

CGM Research Trust

Christchurch, 8083, New Zealand
Gildhøj Privathospital København

Copenhagen, 2605 Brøndby, Denmark
Hospital Universitario LA PAZ

Madrid, Spain
Hospital Vithas Granada

Granada, Spain
Leeds General Infirmary

Leeds, LS1 3EX, United Kingdom
Oxford University Hospitals NHS Foundation Trust

Oxford, Oxford, OX3 9DU, United Kingdom
Royal Preston Hospital

Preston, Lancashire, PR2 9HT, United Kingdom
University Hospital Coventry & Warwickshire

Coventry, CV2 2DX, United Kingdom
University Hospital Of Wales

Cardiff, Wales, CF14 4XW, United Kingdom
University Hospital Southampton Nhs Foundation Trust

Southampton, SO16 6YD, United Kingdom

More trials for these conditions

Other studies related to the condition(s) this trial covers.