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Weight loss and brain training could be the key to beating back pain

NCT ID NCT05811624

Recruiting now Symptom relief Sponsor: Vrije Universiteit Brussel Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study tests whether adding a behavioral weight reduction program (diet, exercise, and behavior changes) to standard pain education and exercise therapy can reduce chronic low back pain in overweight or obese adults. Researchers will compare the combined approach against pain education and exercise alone in 252 participants across multiple countries. The main goal is to see if pain intensity decreases after 12 months, with secondary measures including daily functioning and healthcare use.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
behavioral weight reduction program combined with pain neuroscience education and cognition-targeted exercise therapy
What this could lead to
If it works, this could offer a new, non-drug treatment option for chronic low back pain in people who are overweight or obese, potentially reducing pain and healthcare costs.
What could go wrong
This is a mid-sized trial (252 people) testing a behavioral intervention, not a drug. Results may vary, and the effect on pain might be modest or not last long-term.

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder Overweight

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC LOW-BACK PAIN OVERWEIGHT OR OBESITY

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Email: •••••@•••••

Locations

  • Berner Fachhochschule

    RECRUITING

    Bern, 3012, Switzerland

    Contact

    Contact Email: •••••@•••••

    Contact

    Contact

    Contact

  • Vrije Universiteit Brussel

    RECRUITING

    Brussels, 1090, Belgium

    Contact Email: •••••@•••••

    Contact

    Contact

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