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Can exercise retraining rewire the nervous system in chronic back pain?

NCT ID NCT07818551

Knowledge-focused Sponsor: University Hospital, Brest Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
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Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 14, 2026 · Last updated Sep 18, 2026 · Updated 2 times

Summary

Researchers at a French hospital are observing how pain perception and central sensitization change during a 40-day exercise rehabilitation program on a stationary bike. The study includes 40 adults with chronic low back pain from untreated degenerative spine disease. Participants complete movement control tests, fear-of-movement questionnaires, and pain intensity ratings before and after the program. The goal is to understand whether cognitive and behavioral markers linked to central sensitization shift with exercise.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If researchers find that central sensitization markers shift during exercise rehabilitation, this could help doctors tailor rehabilitation programs for chronic low back pain.
What could go wrong
This is a small observational study of 40 people at one hospital, so it cannot prove that exercise causes any changes. It may not apply to other patients or settings.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 40 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Apr 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult patients, ages 18 through 75 inclusive, admitted to the Musculoskeletal Rehabilitation Unit at the Concarneau Regional Hospital * Chronic low back pain due to degenerative spine disease that has not been treated surgically, with or without referred pain * Low back pain intensity of 4/10 or less on the EVA scale * Pain lasting more than 12 months (= critical period for cerebral impairment) * Oswestry score between 21% and 40% * CSI score of 33/100 or higher for women and 25/100 or higher for men * Patients enrolled in or covered by a social security program * Patients who have signed a consent form Exclusion Criteria: * Patients with acute low back pain of traumatic or neoplastic origin * Patients with a contraindication to moderate-intensity physical activity (Borg 4-5/10 on the modified Borg scale) * Inability to participate in sessions due to pain unrelated to low back pain or a disability * Pregnant or breastfeeding patients * Patients under legal guardianship or conservatorship

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic low-back pain

How to take part

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  1. The places running it

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  2. The official record

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    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • SMR pôle Réadaptation de Cornouaille

    Concarneau, 29900, France

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