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Can gentle back vibration reset the Brain's pain response?

NCT ID NCT07801729

Symptom relief Sponsor: Mahidol University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 03, 2026 · Last updated Sep 04, 2026 · Updated 1 time

Summary

This trial tests whether different settings of lumbar vibration can change how the brain's sensory cortex responds in office workers with chronic low back pain. Participants receive eight random combinations of vibration frequency, amplitude, and direction while researchers measure brain activity with a non-invasive imaging technique. The goal is to find the vibration parameters that produce a favorable and consistent brain response, which could guide future treatments for back pain.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Lumbar sensory stimulation via a customized vibration device
What this could lead to
If it works, this could point toward a non-drug, device-based way to ease chronic low back pain in people who sit for long hours.
What could go wrong
This is a small, early crossover study focused on brain responses, not pain relief. The vibration may not produce a consistent effect or translate into real-world benefit.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 36 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jan 2027

An estimate. Start dates often move.

Expected to finish

Dec 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 60 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Office workers who currently sit for at least 6 hours per workday. * Age 20-60 years. * Chronic nonspecific low back pain for at least 3 months. * Current pain intensity of at least 2/10 on the Numeric Pain Rating Scale. Exclusion Criteria: * History of seizure for either the subject or any family member * Implanted pacemaker * Contraindications for TMS and fNIRS, including open wound, infection, lesions, arteriosclerosis, history of hemophilia, or demand-type pacemaker * Acute cerebral hemorrhage * History of major spinal surgery, fracture, or traumatic injury to the lumbar spine. * Evidence of neurological deficits (e.g., radiculopathy, loss of sensation, or motor weakness in lower limbs). * Diagnosis of systemic inflammatory conditions (e.g., Ankylosing Spondylitis, Rheumatoid Arthritis). * Allergy to adhesives or history of severe skin sensitivity to vibration/mechanical pressure. * Body Mass Index (BMI) \> 30 kg/m2 (to ensure clarity of RUSI, dEMG, and fNIRs signal quality). * Pregnancy (due to changes in spinal biomechanics and hormones)

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic low back pain

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • Faculty of Physical Therapy, Mahidol University

    Salaya, Changwat Nakhon Pathom, 73170, Thailand

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