New schizophrenia drug shows promise in Long-Term safety trial

NCT ID NCT07459647

Recruiting now Disease control Sponsor: MapLight Therapeutics Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Aug 14, 2026 · Updated 3 times

Summary

This study is testing a new drug called ML-007C-MA for adults with schizophrenia. The goal is to see if it is safe and works well over a full year. About 500 people who have recently been in a related study or are new to the trial will take the drug twice daily. Researchers will track side effects and how well the drug controls symptoms.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ML-007C-MA (a combination drug taken twice daily)
What this could lead to: If successful, this could provide a new long-term treatment option for schizophrenia that is safe and effective for daily use.
What could go wrong: This is an early phase 2 open-label study, so results are not definitive. Side effects or lack of effectiveness may still emerge, and the drug may not work for everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

brain disorder central nervous system disorder nervous system disorder psychiatric disorder Psychotic Disorders schizophrenia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SCHIZOPHRENIA

Contacts and locations

Locations

Clinical Site
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Little Rock, Arkansas, 72204, United States
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Little Rock, Arkansas, 72211, United States
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Rogers, Arkansas, 72758, United States
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Bellflower, California, 90706, United States
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Cerritos, California, 90703, United States
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Culver City, California, 90230, United States
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Garden Grove, California, 92845, United States
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Lemon Grove, California, 91945, United States
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Long Beach, California, 90807, United States
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Los Angeles, California, 90015, United States
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Montclair, California, 91763, United States
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Oceanside, California, 92056, United States
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Orange, California, 92868, United States
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Pico Rivera, California, 94596, United States
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Riverside, California, 92506, United States
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San Diego, California, 92123, United States
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Sherman Oaks, California, 91403, United States
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Torrance, California, 90504, United States
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Hollywood, Florida, 33021, United States
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Hollywood, Florida, 33024, United States
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Miami, Florida, 33166, United States
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Miami Lakes, Florida, 33016, United States
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West Palm Beach, Florida, 33407, United States
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Atlanta, Georgia, 30331, United States
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Decatur, Georgia, 30030, United States
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Chicago, Illinois, 60640, United States
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Gaithersburg, Maryland, 20877, United States
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Boston, Massachusetts, 02116, United States
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Watertown, Massachusetts, 02472, United States
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Ann Arbor, Michigan, 48105, United States
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Las Vegas, Nevada, 89119, United States
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Marlton, New Jersey, 08053, United States
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New York, New York, 10029, United States
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Staten Island, New York, 10314, United States
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The Bronx, New York, 10641, United States
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North Canton, Ohio, 44720, United States
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West Chester, Ohio, 45069, United States
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Philadelphia, Pennsylvania, 19104, United States
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Austin, Texas, 78754, United States
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DeSoto, Texas, 75115, United States
Clinical Site
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Richardson, Texas, 75080, United States

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