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Which ADHD drug works best for preschoolers? new study aims to find out.

NCT ID NCT07300956

Not yet recruiting Symptom relief Sponsor: Children's Hospital Medical Center, Cincinnati Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares two medications, methylphenidate and guanfacine, to see which works better for treating ADHD in children ages 3 to 5. About 370 children with moderate to severe ADHD will take one of the drugs, and doctors will rate how much their symptoms improve. The goal is to find the most effective and tolerable treatment for this young age group.

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Conditions

The condition(s) this trial relates to.

attention deficit hyperactivity disorder, inattentive type attention deficit-hyperactivity disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ATTENTION-DEFICIT/HYPERACTIVITY DISORDER (ADHD)

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Boston Children's Hospital

    Boston, Massachusetts, 02115, United States

    Contact

    Contact Email: •••••@•••••

  • Children's Hospital of Philadelphia

    Philadelphia, Pennsylvania, 19104, United States

    Contact Email: •••••@•••••

    Contact

  • Children's Mercy Hospital

    Kansas City, Missouri, 64108, United States

    Contact Email: •••••@•••••

    Contact

  • Cincinnati Children's Hospital Medical Center

    Cincinnati, Ohio, 45229, United States

    Contact Email: •••••@•••••

    Contact

  • Stanford Medicine Children's Health

    Palo Alto, California, 94304, United States

    Contact

    Contact Email: •••••@•••••

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