Brain scans reveal Ketamine's secret: glutamate changes may explain rapid relief
NCT ID NCT06788249
First seen Nov 01, 2025 · Last updated May 16, 2026 · Updated 29 times
Summary
This study looks at how ketamine works in the brain to quickly improve mood in people with major depression. Ten adults with treatment-resistant depression will get a ketamine infusion and have special brain scans to measure changes in glutamate, a key brain chemical. The goal is to understand the mechanism behind ketamine's rapid antidepressant effects, which could lead to new treatments.
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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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University of Pennsylvania
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
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