Ketamine showdown: IV drip vs nasal spray for depression

NCT ID NCT06713616

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares two forms of ketamine for people with depression that hasn't improved with other treatments. One is given through an IV drip, the other as a nasal spray. Researchers want to see which works better, is more acceptable to patients, and has fewer side effects. About 400 adults with moderate to severe depression will take part.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

Depression depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Emory University

    RECRUITING

    Atlanta, Georgia, 30322, United States

    Contact Phone: •••-•••-••••

  • Houston Center for Advanced Psychiatric Treatment

    RECRUITING

    Bellaire, Texas, 77401, United States

    Contact

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • LifeStance Health

    RECRUITING

    Moore, Oklahoma, 73160, United States

    Contact Email: •••••@•••••

  • Mood Institute

    RECRUITING

    Milford, Connecticut, 06461, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • University of Michigan

    ACTIVE_NOT_RECRUITING

    Ann Arbor, Michigan, 48104, United States

  • Yale School of Medicine

    RECRUITING

    New Haven, Connecticut, 06512, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact