Ketamine showdown: IV drip vs nasal spray for depression
NCT ID NCT06713616
First seen Feb 21, 2026 · Last updated May 06, 2026 · Updated 12 times
Summary
This study compares two forms of ketamine—IV ketamine (not FDA-approved for depression) and esketamine nasal spray (FDA-approved)—in 400 adults with treatment-resistant depression. The goal is to see which works better, is more acceptable, and has fewer side effects. Participants receive 8 treatments over one month, and researchers track depression symptoms using standard questionnaires.
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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Emory University
RECRUITINGAtlanta, Georgia, 30322, United States
Contact Phone: •••-•••-••••
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Houston Center for Advanced Psychiatric Treatment
RECRUITINGBellaire, Texas, 77401, United States
Contact
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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LifeStance Health
RECRUITINGMoore, Oklahoma, 73160, United States
Contact Email: •••••@•••••
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Mood Institute
RECRUITINGMilford, Connecticut, 06461, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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University of Michigan
ACTIVE_NOT_RECRUITINGAnn Arbor, Michigan, 48104, United States
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Yale School of Medicine
RECRUITINGNew Haven, Connecticut, 06512, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Conditions
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