Ketamine showdown: IV drip vs nasal spray for depression

NCT ID NCT06713616

Recruiting now Symptom relief Sponsor: Yale University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 31, 2026 · Updated 1 time

Summary

This study compares two forms of ketamine for people with depression that hasn't improved with other treatments. One is given through an IV drip, the other as a nasal spray. Researchers want to see which works better, is more acceptable to patients, and has fewer side effects. About 400 adults with moderate to severe depression will take part.

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Conditions

The condition(s) this trial relates to.

Depression depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DEPRESSION

Contacts and locations

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Locations

Athena Care
RECRUITING

Nashville, Tennessee, 37228, United States
Emory University
RECRUITING

Atlanta, Georgia, 30322, United States
Houston Center for Advanced Psychiatric Treatment
RECRUITING

Bellaire, Texas, 77401, United States
LifeStance Health
ACTIVE_NOT_RECRUITING

Moore, Oklahoma, 73160, United States
Mood Institute
RECRUITING

Milford, Connecticut, 06461, United States

Contact Email: •••••@•••••
Seattle NTC
RECRUITING

Seattle, Washington, 98104, United States
University of Michigan
ACTIVE_NOT_RECRUITING

Ann Arbor, Michigan, 48104, United States
Yale School of Medicine
RECRUITING

New Haven, Connecticut, 06512, United States

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