New depression pill could lift the fog: phase 3 trial underway
NCT ID NCT07076407
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests an experimental drug called azetukalner in 450 adults with moderate-to-severe major depression. Participants take the drug or a placebo daily for 6 weeks to see if it reduces depression symptoms like low mood and loss of pleasure. The goal is to find a new treatment option for people who need better symptom control.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Activmed Practices & Research, Llc - Methuen
RECRUITINGMethuen, Massachusetts, 01844, United States
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Adams Clinical Boston
RECRUITINGBoston, Massachusetts, 02116, United States
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Adams Clinical Watertown
RECRUITINGWatertown, Massachusetts, 02472, United States
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Advanced Quality Medical Research
RECRUITINGOrland Park, Illinois, 60462, United States
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Artemis Institute for Clinical Research
RECRUITINGSan Diego, California, 92103, United States
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Austin Clinical Trial Partners
RECRUITINGAustin, Texas, 78737, United States
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Bio Behavioral Health
RECRUITINGToms River, New Jersey, 08755, United States
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Bioscience Research, LLC
RECRUITINGMount Kisco, New York, 10549, United States
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Boeson Research
RECRUITINGProvo, Utah, 84604, United States
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California Neuroscience Research
RECRUITINGSherman Oaks, California, 91403, United States
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Center for Neurohealth
RECRUITINGLa Jolla, California, 93037, United States
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Clinica Nutrimed Cercetare Sr
RECRUITINGBucharest, 020744, Romania
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Clinical Innovations Inc
RECRUITINGBellflower, California, 90706, United States
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Clinical Medical Research Sp. z o.o.
RECRUITINGKatowice, 40156, Poland
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Delricht Research
RECRUITINGAtlanta, Georgia, 30329, United States
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Emory University Brain Health Center
RECRUITINGAtlanta, Georgia, 30329, United States
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Equipath Health and Research Tampa Bay, Llc
RECRUITINGRiverview, Florida, 33578, United States
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Fieve Clinical Research, Inc.
RECRUITINGNew York, New York, 10017, United States
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Gulfcoast Clinical Research Center
RECRUITINGFort Myers, Florida, 33912, United States
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Harmonex Neuroscience Research
TERMINATEDDothan, Alabama, 36303, United States
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Hospital Universitari Vall D'Hebron
RECRUITINGBarcelona, 8035, Spain
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IMA Clinical Research
RECRUITINGNew York, New York, 10128, United States
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In Vivo Sp. z.o.o.
RECRUITINGBydgoszcz, 85-048, Poland
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Insight Clinical Trials
RECRUITINGIndependence, Ohio, 44195, United States
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Institute of Living
RECRUITINGHartford, Connecticut, 06106, United States
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Liptovska Nemocnica S Poliklinikou Mudr. Ivana Stodolu Liptovsky Mikulas
RECRUITINGLiptovský Mikuláš, 03123, Slovakia
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Lumina Clinical Research Center
RECRUITINGCherry Hill, New Jersey, 08002, United States
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Magnolia Clinical Research, Llc
RECRUITINGCary, North Carolina, 27511, United States
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Oulu Mentalcare Oy
RECRUITINGOulu, 90100, Finland
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Pacific Clinical Research Management Group
TERMINATEDUpland, California, 91786, United States
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Pharmasite Research Inc.
RECRUITINGBaltimore, Maryland, 21208-6605, United States
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Pillar Clinical Research
RECRUITINGBentonville, Arkansas, 72712, United States
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Praktyka Lekarska Malgorzata Wojtanowska-Bogacka
RECRUITINGPoznan, 60192, Poland
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Princeton Medical Institute
RECRUITINGPrinceton, New Jersey, 08540, United States
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Psychiatric Care and Research Center
RECRUITINGO'Fallon, Missouri, 63368, United States
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SanRo Clinical Research Group
RECRUITINGBryant, Arkansas, 72022, United States
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Sarkis Clinical Trials
RECRUITINGGainesville, Florida, 32607, United States
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Smart Trials, LLC
RECRUITINGJefferson, Louisiana, 70121, United States
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Sooner Clinical Research
RECRUITINGOklahoma City, Oklahoma, 73116, United States
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Specjalistyczna Praktyka Lekarska, Filip Rybakowski
RECRUITINGPoznan, 60744, Poland
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St. Charles Psychiatric Associates - Midwest Research Group
RECRUITINGSaint Charles, Missouri, 63304, United States
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Suomen Terveystalo Oy
RECRUITINGHelsinki, 00180, Finland
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University of Alabama at Birmingham, Huntsville Regional Medical Campus
RECRUITINGHuntsville, Alabama, 35801, United States
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Vitalix Clinical, Inc
RECRUITINGWorcester, Massachusetts, 01608, United States
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