Brain wave test may predict ketamine success for severe depression

NCT ID NCT06480201

First seen Jun 27, 2026 · Last updated Jul 07, 2026 · Updated 2 times

Summary

This study looks at whether specific brain wave patterns (gamma oscillations) can help predict how well ketamine therapy works for people with treatment-resistant depression. Researchers will measure brain activity using EEG before and during ketamine treatment and track depression symptoms over four weeks. The goal is to find a simple brain-based marker that could guide personalized treatment decisions for those who haven't benefited from other antidepressants.

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Conditions

The condition(s) this trial relates to.

Depression Depressive Disorder, Treatment-Resistant major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Texas A&M (Houston Methodist Hospital Location)

    RECRUITING

    Houston, Texas, 77030, United States

  • Wells Medicine

    RECRUITING

    Houston, Texas, 77024, United States

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