Can a computer program lift veterans out of depression?

NCT ID NCT06217198

Recruiting now Symptom relief Sponsor: VA Office of Research and Development Source: ClinicalTrials.gov ↗

First seen Aug 10, 2026 · Last updated Aug 11, 2026 · Updated 1 time

Summary

This trial tests whether Deprexis, a self-guided online program, can reduce depressive symptoms and improve daily functioning in veterans with mild to moderate depression. Participants will use the 12-module program over 8 weeks, and their progress will be compared to those receiving usual care. The goal is to see if this accessible, remote intervention can be a helpful option for veterans.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Deprexis, an internet-delivered, self-guided behavioral intervention with 12 interactive modules for depression
What this could lead to: If effective, Deprexis could offer veterans a convenient, remote treatment option to reduce depressive symptoms and improve daily functioning.
What could go wrong: The trial is relatively small and early, and results may not generalize. As a self-guided program, engagement and adherence could vary, and it may not work for everyone.

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Conditions

The condition(s) this trial relates to.

Depression depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DEPRESSION

Contacts and locations

Locations

Central Texas Veterans Health Care System Waco VA Medical Center, Waco, TX
RECRUITING

Waco, Texas, 76711, United States

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