Could a few doses of ketamine help both depression and alcohol addiction?
NCT ID NCT06090422
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study investigates whether ketamine, given as four intravenous infusions over two weeks, can reduce depression and alcohol cravings in adults who have both conditions. Participants are already in inpatient addiction therapy and are randomly assigned to receive either ketamine or a low-dose sedative (midazolam) as a comparison. The trial tracks changes in depression severity and alcohol craving over six months to see if ketamine offers added benefit beyond standard care.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Ketamine hydrochloride
What this could lead to
If successful, this could point toward a new treatment approach for people struggling with both depression and alcohol use disorder.
What could go wrong
This is an early-phase trial with only 34 participants, so results may not apply to everyone. Ketamine can cause side effects like dissociation and blood pressure changes.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Department of Addiction, University Hospital of North Norway
RECRUITINGTromsø, Norway
Contact Phone: •••-•••-•••• Email: •••••@•••••