Could a 5-Day brain stimulation blitz ease depression in PTSD?

NCT ID NCT07682207

Not yet recruiting Symptom relief Sponsor: Lawson Research Institute of St. Joseph's Source: ClinicalTrials.gov ↗

First seen Jul 02, 2026 · Last updated Jul 02, 2026

Summary

This pilot study tests whether a faster schedule of non-invasive magnetic brain stimulation, called accelerated intermittent theta burst stimulation (iTBS), is practical and safe for adults with both PTSD and major depression. Participants receive six short sessions per day for five days. The study focuses on feasibility, tolerability, and changes in symptoms and brain activity over 12 weeks.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: accelerated intermittent theta burst stimulation (iTBS)
What this could lead to: If this faster schedule proves practical and safe, it could offer a quicker, non-invasive treatment option for depression in people with PTSD.
What could go wrong: This is a very small, early feasibility study with only 16 participants. It is not designed to prove effectiveness, and results may not apply to everyone. Side effects like headache or discomfort are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

combat disorder Depression major depressive disorder post-traumatic stress disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MAJOR DEPRESSIVE DISORDER (MDD) POST-TRAUMATIC STRESS DISORDER (PTSD)

Contacts and locations

Locations

St. Joseph's Health Care London, Parkwood Institute Mental Health Care Building

London, Ontario, N6C 0A7, Canada

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