Could a memory drug boost antidepressants? small brain study launches
NCT ID NCT07139834
First seen Jun 25, 2026 · Last updated Jul 15, 2026 · Updated 3 times
Summary
This early study is testing whether adding the drug memantine (used for Alzheimer's) to a standard antidepressant can improve how the brain processes memories in people with major depression. Thirty adults aged 18-50 will take an SSRI for 11 weeks, and for the last 6 weeks they will also receive either memantine or a placebo. Researchers will use brain scans and memory tasks to see if the combination works better than the antidepressant alone.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- escitalopram (or sertraline) and extended-release memantine
- What this could lead to
- If successful, this could point toward a new way to boost memory and thinking in people with depression by adding memantine to standard antidepressants.
- What could go wrong
- This is a very small, early-phase study (30 people) focused on brain scans and cognitive tests, not on curing depression. The results may not lead to a new treatment and could fail to show any benefit.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
New York State Psychiatric Institute (NYSPI)
RECRUITINGNew York, New York, 10032, United States
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