Could KarXT be the key to treating teen schizophrenia?

NCT ID NCT07288567

Recruiting now Disease control Sponsor: Bristol-Myers Squibb Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Aug 14, 2026 · Updated 9 times

Summary

This phase 3 trial is testing whether the drug KarXT can safely and effectively treat schizophrenia in adolescents aged 13 to 17. About 166 teens will receive either KarXT or a placebo, and researchers will track changes in symptoms like delusions and social withdrawal. The goal is to see if KarXT offers a new treatment option for this age group.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: KarXT (also known as BMS-986510)
What this could lead to: If it works, this could offer a new treatment option for teenagers with schizophrenia, potentially easing symptoms like hallucinations and social withdrawal.
What could go wrong: This is still a clinical trial, so it's not proven yet. The drug may not work better than a placebo, and side effects are possible. Results may not apply to all teens.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

schizophrenia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SCHIZOPHRENIA

Contacts and locations

Locations

Advanced Research Center Inc.
RECRUITING

Anaheim, California, 92805, United States
Apg Research, Llc
RECRUITING

Orlando, Florida, 32803, United States
Atlanta Center for Medical Research
RECRUITING

Atlanta, Georgia, 30331, United States
Boston Children's Hospital
RECRUITING

Boston, Massachusetts, 02115, United States
Cabinet Medical Individual Dr Gheorghita Karina Lidia
RECRUITING

Bucharest, 031871, Romania
Cluj Napoca Emergency Hospital for Children, Department of Pediatric Psychiatry
RECRUITING

Cluj-Napoca, 400370, Romania
Denali Health Atlanta, LLC
RECRUITING

Stone Mountain, Georgia, 30083, United States
EmVenio Research Center - Prime Healthcare
RECRUITING

Chicago, Illinois, 60622, United States
Emergency Clinical Hospital For Children Louis Turcanu Timis
RECRUITING

Timișoara, 300329, Romania
Goryokai Medical Corporation - Goryokai Hospital
RECRUITING

Sapporo, Hokkaido, 002-8029, Japan
Inland Psychiatric Medical Group.
RECRUITING

Chino, California, 91710, United States
Local Institution - 0001
NOT_YET_RECRUITING

Barranquilla, 080020, Colombia
Local Institution - 0008
NOT_YET_RECRUITING

Iași, 700282, Romania
Local Institution - 0009
NOT_YET_RECRUITING

Pereira, Risaralda Department, 660003, Colombia
Local Institution - 0020
NOT_YET_RECRUITING

Bogotá, 111166, Colombia
Local Institution - 0025
NOT_YET_RECRUITING

Zentsujichó, Kagawa-ken, 765-8507, Japan
Local Institution - 0029
NOT_YET_RECRUITING

Bucharest, Bucharest, 041914, Romania
Local Institution - 0030
NOT_YET_RECRUITING

Sibiu, 550082, Romania
Local Institution - 0040
NOT_YET_RECRUITING

Bucharest, 021056, Romania
Local Institution - 0050
NOT_YET_RECRUITING

Richmond, Virginia, 23284, United States
Local Institution - 0056
NOT_YET_RECRUITING

Ōta-ku, Tokyo, 1438541, Japan
Local Institution - 0059
NOT_YET_RECRUITING

Worcester, Massachusetts, 01608, United States
Local Institution - 0061
NOT_YET_RECRUITING

Great Neck, New York, 11021, United States
Local Institution - 0062
NOT_YET_RECRUITING

Miyakonojō, Miyazaki, 885-0093, Japan
Local Institution - 0063
NOT_YET_RECRUITING

Yokohama, Kanagawa, 213-8507, Japan
Local Institution - 0066
NOT_YET_RECRUITING

Spring, Texas, 77381, United States
Local Institution - 0075
NOT_YET_RECRUITING

Chikugo-Shi, Fukuoka, 833-0041, Japan
Local Institution - 0086
NOT_YET_RECRUITING

Bunkyo-ku, Tokyo, 113-8431, Japan
Local Institution - 0089
NOT_YET_RECRUITING

San Francisco, California, 94158, United States
Local Institution - 0109
NOT_YET_RECRUITING

Bello, Antioquia, 051053, Colombia
Local Institution - 0113
NOT_YET_RECRUITING

Nashville, Tennessee, 37212, United States
Local Institution - 0118
NOT_YET_RECRUITING

Plano, Texas, 75093, United States
Local Institution - 0119
NOT_YET_RECRUITING

Hollywood, Florida, 33024, United States
Local Institution - 0120
NOT_YET_RECRUITING

Houston, Texas, 77043, United States
Local Institution - 0122
NOT_YET_RECRUITING

Chicago, Illinois, 60611, United States
Proscience Research Group
RECRUITING

Culver City, California, 90230, United States
Salveo Integrative Health - Lawrenceville
RECRUITING

Lawrenceville, Georgia, 30046, United States
University of Cincinnati Dept of Psychiatry and Behavioral Neuroscience
RECRUITING

Cincinnati, Ohio, 45219, United States
VAST Clinical Research
RECRUITING

Garland, Texas, 75043, United States

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