Learning disability

This study tests whether a gentle electrical current applied to the scalp during reading lessons can improve reading skills in children aged 7 to 17 with dyslexia or reading difficulties. Half the participants receive active stimulation, while the other half receive a sham (place…

This trial tests whether combining aerobic exercise with a targeted reading therapy, called Phono-Motor Therapy, can improve reading skills in people who have reading difficulties after a stroke. Participants will receive both interventions, and researchers will measure changes i…

This study tests whether playing action video games can improve reading in children with dyslexia by training their visual attention. About 76 Cantonese-speaking children with dyslexia will be randomly assigned to play either an action game or a non-action game for 12 hours. Rese…

This study tests whether chewing xylitol gum during pregnancy can reduce the risk of preterm birth and low birthweight. 6,000 pregnant women in Malawi will chew either a high or low dose of xylitol gum or a placebo gum. The goal is to see if improving oral health with xylitol lea…

This study is testing a 12-week early intervention program for preschoolers (ages 2 to 5) with developmental disorders like autism or intellectual disability. The program provides 12 hours of therapy each week, either at a center or at home, aiming to improve social communication…

This study tests whether combining a gentle, non-invasive brain stimulation technique called rTMS with personalized language training can improve language skills in children aged 2 to 5 with global developmental delay. About 50 children will be split into two groups: one gets bot…

This study tests a personalized coaching program for parents and early intervention professionals to reduce problem behaviors like aggression and screaming in children up to 5 years old with developmental delays. Researchers will observe and track changes in behavior during short…

This study tests whether immersive virtual reality (VR) training can help children aged 6 to 13 who struggle with handwriting. Researchers will enroll 12 children and use a special tool to measure writing quality before, during, and after VR sessions. The goal is to see if VR mak…

This study tests a 15-week shared reading program called Sit Together and Read (STAR) for children ages 4 to 5 with developmental language disorder. Caregivers are guided to read with their child using specific techniques to build print and letter knowledge. The study also looks …

This study tests whether playing a special online game for 20 minutes, four times a week, can improve memory and thinking speed in people with multiple sclerosis. Researchers will compare the game group to a control group receiving standard care. The trial aims to enroll 150 adul…

This study aims to learn more about childhood-onset behavioral, psychiatric, and developmental disorders by observing people of all ages who have these conditions, along with their family members. Researchers will collect medical histories, perform psychiatric assessments, and ma…

This trial asks whether a gentle electrical current applied to the scalp during language lessons can speed up and improve how adults learn a new language. Healthy adults who are learning or planning to learn a language are randomly assigned to receive either real or sham (placebo…

This observational study looks at how the brain responds when watching others perform actions, focusing on the mirror neuron system. Researchers will measure brain activity in healthy adults and infants, including those at risk for developmental delays, using EEG and fNIRS. The g…

This study from Stanford University is looking at how a 6-week math training program changes brain activity and thinking skills in children with math learning disabilities (dyscalculia). About 180 children aged 6-12 will do math problems on a tablet at home and get weekly one-on-…

This study follows pregnant women and their children from the first trimester through toddlerhood to explore how stress, early social experiences, and genetics interact. Using simple at-home activities like questionnaires, video recordings, and cheek swabs, researchers will look …

This trial tests whether training novice bronchoscopists using computer-generated 'digital twin' models of real patient airways — showing a wide range of normal anatomical variations — can help them learn the procedure faster than traditional training with a single, uniform airwa…

This study looks at how the brain uses feedback to control speech in 90 adults aged 18-50, including people who stutter, have dyslexia, and those with typical speech. Participants will do speech tasks, have an MRI scan, and receive mild brain stimulation to see how different brai…

This study screens up to 5,000 healthy volunteers and people at risk for psychiatric or neurodevelopmental disorders like autism. Participants undergo interviews, cognitive tests, and other evaluations to see if they qualify for future research studies at NIH. The goal is to buil…

This study looks at facial features of males aged 2 to 40 with creatine transporter deficiency (CTD), a genetic disorder that causes intellectual disability, seizures, and behavioral issues. Researchers will examine photos of participants to see if they share common facial traits…

This study adapts PlayReadVIP, a program that coaches parents on positive interactions during reading and play, for use in family child care homes. Researchers will enroll 240 providers to see if the program improves provider confidence and children's literacy behaviors. The goal…

This study follows 50 children and adults with Baker Gordon Syndrome, a rare genetic disorder, to track how the condition changes over time. Participants will undergo brain scans, EEGs, and genetic testing, and complete developmental assessments. The goal is to create better tool…

This study looks at people who have changes in a gene called FOXP1, which can cause developmental delays, speech problems, and autism-like traits. Researchers will use interviews, play-based assessments, and genetic tests to better understand these conditions. The goal is to lear…

This study explores whether a gentle electrical current applied to the brain (called transcranial random noise stimulation) can improve how adults learn to connect letters with sounds — a key skill for reading. Researchers will enroll 60 right-handed, German-speaking adults aged …

This study explores whether a special MRI technique can help people who have had a stroke improve their reading. Participants will practice controlling their own brain activity using real-time feedback from the MRI scanner. The goal is to retrain the brain's language areas to wor…

This study tests whether a computer model can predict which reading treatment works best for people who developed dyslexia after a stroke. Twelve participants will each try two different therapies—phonomotor treatment and semantic feature analysis—for 60 hours each. The goal is t…

This study looks at whether children diagnosed with a specific learning disorder that affects written expression have different fingertip touch, hand grip strength, and pain sensitivity compared to healthy children. Researchers will measure these sensations using simple tools lik…

This study tests a two-week online program designed to help kindergarten and elementary school teachers better support autistic children and those with developmental delays. About 70 public school teachers will either take the program or receive standard materials. Researchers wi…

This study looks at how daridorexant, a sleep medication that blocks the brain chemical orexin, affects emotional processing and learning in 62 healthy adults. Participants take a single dose of the drug or a placebo and then complete tasks that measure emotional responses and le…

This study looks at 500 Polish children aged 3 to 6 to understand what factors are linked to developmental delays. Researchers will test thinking, language, and social-emotional skills, and ask parents about their child's behavior. The goal is to find patterns that could help ide…

This study looks at how teaching children to recognize and play with sounds in words (phonological awareness) can boost their reading and spelling skills. Researchers will compare two teaching approaches in 720 prekindergarten and kindergarten children who are behind in sound awa…

This study tests a dual executive function training program for 288 primary school children aged 6-12 with ADHD, dyslexia, or autism. The program includes weekly group sessions to improve thinking, emotional control, and behavior. Researchers will measure changes in memory, atten…

This study follows 1,000 people who have certain genetic changes (hnRNP and others) that may cause developmental delays, autism, seizures, or muscle problems. Researchers collect medical records, school reports, and questionnaires to see how these gene variants affect behavior, t…

This study tests whether adding working memory training to math tutoring helps first graders at risk for math disabilities more than math tutoring alone. 300 children will be randomly assigned to one of three groups: combined memory and math training, math with reading instructio…

The Dragonfly study is an international observational project tracking the development of 250 children and adults with CTNNB1 neurodevelopmental syndrome. Researchers will collect medical history, perform neurological exams, and use questionnaires to understand how symptoms and a…