New depression drug SPT-300 enters Mid-Stage trial

NCT ID NCT07065240

Recruiting now Symptom relief Sponsor: Seaport Therapeutics Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 14, 2026 · Updated 2 times

Summary

This study tests a new drug called SPT-300 in 360 adults with major depressive disorder, with or without anxiety. Participants will receive either the drug or a placebo for 6 weeks to see if it reduces depression symptoms. The goal is to find a safe and effective new treatment option.

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Conditions

The condition(s) this trial relates to.

anxiety disorder Depression depressive disorder major depressive disorder mood disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MAJOR DEPRESSIVE DISORDER (MDD) MAJOR DEPRESSIVE DISORDER WITH ANXIOUS DISTRESS

Contacts and locations

Locations

Seaport Investigator Site
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Chino, California, 91710, United States
Seaport Investigator Site
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Garden Grove, California, 92845-2506, United States
Seaport Investigator Site
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Glendale, California, 91206, United States
Seaport Investigator Site
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Redlands, California, 92373, United States
Seaport Investigator Site
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San Jose, California, 95124, United States
Seaport Investigator Site
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Cromwell, Connecticut, 06416, United States
Seaport Investigator Site
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Jacksonville, Florida, 32256, United States
Seaport Investigator Site
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Lauderhill, Florida, 33319, United States
Seaport Investigator Site
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Orlando, Florida, 32801, United States
Seaport Investigator Site
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Palm Bay, Florida, 32905, United States
Seaport Investigator Site
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West Palm Beach, Florida, 33407, United States
Seaport Investigator Site
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Atlanta, Georgia, 30328, United States
Seaport Investigator Site
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Decatur, Georgia, 30030, United States
Seaport Investigator Site
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Marietta, Georgia, 30060, United States
Seaport Investigator Site
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Boston, Massachusetts, 02116, United States
Seaport Investigator Site
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Boston, Massachusetts, 02131, United States
Seaport Investigator Site
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Russells Mills, Massachusetts, 02747, United States
Seaport Investigator Site
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St Louis, Missouri, 63141, United States
Seaport Investigator Site
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Brooklyn, New York, 11235, United States
Seaport Investigator Site
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Cedarhurst, New York, 11516, United States
Seaport Investigator Site
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New York, New York, 10029, United States
Seaport Investigator Site
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Staten Island, New York, 10314, United States
Seaport Investigator Site
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Independence, Ohio, 44131, United States
Seaport Investigator Site
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North Canton, Ohio, 44720, United States
Seaport Investigator Site
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Allentown, Pennsylvania, 18104, United States
Seaport Investigator Site
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Media, Pennsylvania, 19063, United States
Seaport Investigator Site
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Dallas, Texas, 75231, United States
Seaport Investigator Site
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Irving, Texas, 75062, United States
Seaport Investigator Site
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Richardson, Texas, 75080, United States
Seaport Investigator Site
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Everett, Washington, 98201, United States
Seaport Investigator Site
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Plovdiv, 4004, Bulgaria
Seaport Investigator Site
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Sofia, 1000, Bulgaria
Seaport Investigator Site
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Sofia, 1680, Bulgaria
Seaport Investigator Site
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Brno, 602 00, Czechia
Seaport Investigator Site
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Pilsen, 301 00, Czechia
Seaport Investigator Site
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Prague, 100 00, Czechia
Seaport Investigator Site
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Prague, 110 00, Czechia
Seaport Investigator Site
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Prague, 160 00, Czechia
Seaport Investigator Site
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Prague, 186 00, Czechia
Seaport Investigator Site
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Berlin, Brandenburg, D-10629, Germany
Seaport Investigator Site
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Schwerin, Mecklenburg-Vorpommern, 19053, Germany
Seaport Investigator Site
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Bad Homburg, 61348, Germany
Seaport Investigator Site
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Chemnitz, 09111, Germany
Seaport Investigator Site
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Budapest, 1033, Hungary
Seaport Investigator Site
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Budapest, 1083, Hungary
Seaport Investigator Site
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Budapest, 1134, Hungary
Seaport Investigator Site
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Bełchatów, 97-400, Poland
Seaport Investigator Site
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Bialystok, 15-404, Poland
Seaport Investigator Site
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Bialystok, 15-464, Poland
Seaport Investigator Site
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Bydgoszcz, 85-080, Poland
Seaport Investigator Site
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Gdansk, 80-438, Poland
Seaport Investigator Site
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Katowice, 40-600, Poland
Seaport Investigator Site
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Leszno, 64-100, Poland
Seaport Investigator Site
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Poznan, 60-744, Poland
Seaport Investigator Site
WITHDRAWN

Torun, 87-100, Poland
Seaport Investigator Site
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Tuszyn, 95-080, Poland
Seaport Investigator Site
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Warsaw, 00-124, Poland
Seaport Investigator Site
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Wroclaw, 54-617, Poland
Seaport Investigator Site
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Bratislava, 82007, Slovakia
Seaport Investigator Site
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Rimavská Sobota, 979 01, Slovakia
Seaport Investigator Site
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Vranov nad Topľou, 09301, Slovakia

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