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Could ritalin help kids with sickle cell disease? new pilot trial launches

NCT ID NCT07226219

Recruiting now Symptom relief Sponsor: St. Jude Children's Research Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 07, 2026 · Updated 2 times

Summary

This pilot study at St. Jude Children's Research Hospital is testing whether a daily dose of extended-release methylphenidate (Ritalin) can safely improve attention, thinking, and school performance in children aged 8 to 17 with sickle cell disease. The trial will enroll 72 participants and focus on whether families can stick with the treatment for 4 weeks, while also tracking any side effects and changes in behavior. It is an early-stage study, so the main goal is to see if this approach is feasible and acceptable, not yet to prove it works.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Methylphenidate (extended-release Ritalin)
What this could lead to
If it works, this could point toward a safe way to help children with sickle cell disease focus better at school and home.
What could go wrong
This is a very early, small pilot study focused on feasibility, not proof of effectiveness. Side effects of stimulants like methylphenidate may include appetite loss, sleep problems, or mood changes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

attention deficit hyperactivity disorder, inattentive type attention deficit-hyperactivity disorder Cognitive Dysfunction sickle cell disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ATTENTION-DEFICIT/HYPERACTIVITY DISORDER (ADHD) COGNITIVE IMPAIRMENT EXECUTIVE DYSFUNCTION SICKLE CELL DISEASE

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • St. Jude Children's Research Hospital

    RECRUITING

    Memphis, Tennessee, 38105, United States

    Contact Email: •••••@•••••

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