Brain health behind the wheel: study tracks how depression and Alzheimer's change driving in seniors
NCT ID NCT05446805
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at how depression and very early (preclinical) Alzheimer's disease affect driving habits in adults aged 65 and older who still drive regularly. Participants will have their driving tracked with a GPS device and undergo brain scans to measure Alzheimer-related proteins. The goal is to understand whether these conditions lead to unsafe driving, which could inform future safety recommendations.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Flortaucipir (F 18 AV-1451) and Pittsburgh Compound B
- What this could lead to
- If successful, this research could help identify driving risks in older adults with depression or early Alzheimer's, potentially leading to safety guidelines or interventions.
- What could go wrong
- This is an observational study, not a treatment trial. It may not find clear links between depression, Alzheimer's, and driving behavior, and results may not apply to all older drivers.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Washington University School of Medicine
RECRUITINGSt Louis, Missouri, 63110, United States
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