Which ketamine works better for severe depression? a 5-Year study aims to find out

NCT ID NCT06725277

Recruiting now Knowledge-focused Sponsor: Yale University Source: ClinicalTrials.gov ↗

First seen Jul 31, 2026 · Last updated Jul 31, 2026

Summary

This study follows 450 people with treatment-resistant depression who are starting or continuing treatment with either IV ketamine or Spravato (esketamine) nasal spray. Over five years, researchers will track how satisfied patients are with their treatment, how well it works, and any safety concerns. The goal is to see which approach people stick with and prefer in real-world settings.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: IV ketamine and intranasal esketamine (Spravato)
What this could lead to: If this trial succeeds, it could clarify which of the two ketamine-based treatments patients prefer and find more effective over the long term, guiding more personalized depression care.
What could go wrong: This is an observational study, so it cannot prove cause and effect. Differences in outcomes might be due to patient characteristics or treatment settings rather than the drugs themselves.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MAJOR DEPRESSION DISORDER

Contacts and locations

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Locations

Athena Care
RECRUITING

Nashville, Tennessee, 37228, United States
Emory University
RECRUITING

Atlanta, Georgia, 30322, United States
Houston Center for Advanced Psychiatric Treatment
RECRUITING

Bellaire, Texas, 77401, United States
LifeStance Health
ACTIVE_NOT_RECRUITING

Moore, Oklahoma, 73160, United States
Mood Institute
RECRUITING

Milford, Connecticut, 06461, United States

Contact Email: •••••@•••••
Seattle NTC
RECRUITING

Seattle, Washington, 98104, United States
University of Michigan
ACTIVE_NOT_RECRUITING

Ann Arbor, Michigan, 48104, United States
Yale School of Medicine
RECRUITING

New Haven, Connecticut, 06512, United States

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