Cure My Disease

Don't miss your cure!

 Log in / Sign up

Psychedelic DMT studied for depression relief in early human trial

NCT ID NCT06671977

Recruiting now Symptom relief Sponsor: Deepak C. D'Souza Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This Phase 1 study is testing the safety and brain effects of DMT, a psychedelic drug, in 60 adults with depression and healthy volunteers. Participants receive low or medium doses of DMT, THC, or a placebo, and researchers monitor mood, anxiety, and brain activity. The goal is to see if DMT can safely produce changes in the brain that might ease depression, but this is very early research and not a proven treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
DMT (dimethyltryptamine), a psychedelic drug
What this could lead to
If successful, this could point toward a new, fast-acting treatment for depression that works by promoting brain changes.
What could go wrong
This is a very early Phase 1 study with only 60 participants, focused on safety and brain activity, not on proving depression relief. Psychedelic side effects like anxiety or challenging experiences are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for DEPRESSION are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

Depression depressive disorder major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DEPRESSION MAJOR DEPRESSION DISORDER

Contacts and locations

Locations

  • Biological Studies Unit at the VA Connecticut Healthcare System, Yale School of Medicine,

    RECRUITING

    West Haven, Connecticut, 06516, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.