Can antidepressants rewire how older adults see the future?

NCT ID NCT07681492

Recruiting now Knowledge-focused Sponsor: Hospital Center Guillaume Régnier Source: ClinicalTrials.gov ↗

First seen Jul 02, 2026 · Last updated Jul 02, 2026

Summary

This study investigates how depression and antidepressants influence the way older adults update their beliefs about future events. Researchers compare 31 patients aged 65+ with major depression who are switching antidepressants to 31 healthy volunteers of the same age. Participants complete a belief-updating task and mood assessments at the start and after 12 weeks of treatment, with weekly check-ins on expectations and mood.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could reveal how antidepressants change the way older adults update their beliefs about the future, potentially improving treatment approaches.
What could go wrong: This is a small observational study (62 participants) focused on understanding mechanisms, not testing a new treatment. Results may not apply broadly.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

bipolar depression Depression depressive disorder major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BELIEFS BELIEFS ABOUT FUTURE DEPRESSION MAJOR DEPRESSIVE EPISODE (MDE)

Contacts and locations

Locations

Centre Hospitalier Guillaume Regnier
NOT_YET_RECRUITING

Rennes, 35700, France
Centre Hospitalier Guillaume Régnier
RECRUITING

Rennes, 35700, France

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