New hope for bipolar mania? phase 3 trial of KarXT begins
NCT ID NCT06951698
First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 2 times
Summary
This Phase 3 study tests whether KarXT, a combination of two drugs, can safely reduce manic symptoms in people with Bipolar-I disorder. About 274 participants hospitalized for mania will receive either KarXT or a placebo. The main goal is to see if KarXT improves scores on a standard mania rating scale over time.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
KarXT (a combination of xanomeline and trospium chloride)
What this could lead to
If successful, KarXT could offer a new treatment option for managing manic episodes in Bipolar-I disorder, potentially with fewer side effects than current therapies.
What could go wrong
This is a Phase 3 trial, but results are not guaranteed. The drug may not prove more effective than placebo, and side effects could emerge. It is not a cure and will require ongoing management.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Locations
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"University Multiprofile Hospital for Active Treatment - Dr. Georgi Stranski" EAD
RECRUITINGPleven, 5800, Bulgaria
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Advanced Research Center Inc.
RECRUITINGAnaheim, California, 92805, United States
Contact Phone: •••-•••-••••
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Advanced Research Institute of Miami
RECRUITINGHomestead, Florida, 33033, United States
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CITrials
RECRUITINGBellflower, California, 90706, United States
Contact Phone: •••-•••-••••
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Catalina Research Institute, LLC
RECRUITINGMontclair, California, 91763, United States
Contact Phone: •••-•••-••••
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CenExel iResearch, LLC
RECRUITINGSavannah, Georgia, 31405, United States
Contact Phone: •••-•••-••••
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Center for Mental Health Prof. Dr. Ivan Temkov
RECRUITINGBurgas, 8001, Bulgaria
Contact Phone: •••-•••-••••
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Centrum Medyczne HCP
RECRUITINGPoznan, Greater Poland Voivodeship, 61-485, Poland
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Clinica Inventiva
RECRUITINGTuszyn, 95-080, Poland
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Clinica del Prado
RECRUITINGLas Heras, Mendoza Province, 5539, Argentina
Contact Phone: •••-•••-••••
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Collaborative Neuroscience Research, LLC
RECRUITINGLong Beach, California, 90806, United States
Contact Phone: •••-•••-••••
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Connecticut Mental Health Center
RECRUITINGNew Haven, Connecticut, 06519, United States
Contact Phone: •••-•••-••••
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Goryokai Medical Corporation - Goryokai Hospital
RECRUITINGSapporo, Hokkaido, 002-8029, Japan
Contact Phone: •••-•••-••••
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Health Synergy Clinical Research
RECRUITINGWest Palm Beach, Florida, 33407, United States
Contact Phone: •••-•••-••••
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Hospital Italiano de Buenos Aires
RECRUITINGABB, Buenos Aires F.D., C1199ABB, Argentina
Contact Phone: •••-•••-••••
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Hotei Hospital
RECRUITINGKōnan, Aichi-ken, 4838248, Japan
Contact Phone: •••-•••-••••
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Innovative Clinical Research, Inc.
RECRUITINGMiami Lakes, Florida, 33016, United States
Contact Phone: •••-•••-••••
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Instytut Psychiatrii i Neurologii
RECRUITINGWarsaw, Masovian Voivodeship, 02-957, Poland
Contact Phone: •••-•••-••••
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Kansai Medical University Medical Center
RECRUITINGMoriguchi, Osaka, 570-8507, Japan
Contact Phone: •••-•••-••••
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Klinika Psychiatrii Uniwersytet Medyczny w Białymstoku
RECRUITINGBialystok, Podlaskie Voivodeship, 15-272, Poland
Contact Phone: •••-•••-••••
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Kuramitsu Hospital
RECRUITINGFukuoka, 819-0037, Japan
Contact Phone: •••-•••-••••
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Local Institution - 0014
NOT_YET_RECRUITINGCerritos, California, 90703, United States
Contact
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Local Institution - 0015
NOT_YET_RECRUITINGMiami Lakes, Florida, 33016, United States
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Local Institution - 0029
WITHDRAWNIrving, Texas, 75062, United States
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Local Institution - 0081
WITHDRAWNIruma, Saitama, 350-0495, Japan
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Local Institution - 0084
WITHDRAWNOsaka, 590-0018, Japan
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Local Institution - 0100
WITHDRAWNKitakyushu, Fukuoka, 803-0831, Japan
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Local Institution - 0102
NOT_YET_RECRUITINGSosnowiec, Silesian Voivodeship, 41-200, Poland
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Local Institution - 0109
NOT_YET_RECRUITINGMendoza, 5502, Argentina
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Local Institution - 0111
NOT_YET_RECRUITINGGdansk, Pomeranian Voivodeship, 80-214, Poland
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Local Institution - 0114
NOT_YET_RECRUITINGBudapest, 1135, Hungary
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Local Institution - 0126
NOT_YET_RECRUITINGKropyvnytskyi, 25491, Ukraine
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Local Institution - 0129
NOT_YET_RECRUITINGKyiv, 04080, Ukraine
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Local Institution - 0130
NOT_YET_RECRUITINGDnipro, 49115, Ukraine
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Local Institution - 0131
NOT_YET_RECRUITINGSmila, Cherkasy Oblast, 20708, Ukraine
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Local Institution - 0132
NOT_YET_RECRUITINGPoltava, 36013, Ukraine
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Local Institution - 0137
NOT_YET_RECRUITINGTernopil, 46027, Ukraine
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M2M Med
RECRUITINGRybnik, Silesian Voivodeship, 44-200, Poland
Contact Phone: •••-•••-••••
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MHAT "Dr. Ival Seliminski"
RECRUITINGSliven, 8800, Bulgaria
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Mental Health Center - Vratsa
RECRUITINGVratsa, 3000, Bulgaria
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Miyazaki Prefectural Miyazaki Hospital
RECRUITINGMiyazaki, 880-8510, Japan
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NRC Research Institute
RECRUITINGOrange, California, 92868, United States
Contact Phone: •••-•••-••••
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Narimasu Kosei Hospital
RECRUITINGtabashi City, Tokyo, 175-0091, Japan
Contact Phone: •••-•••-••••
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National Center of Neurology and Psychiatry
RECRUITINGKodaira, Tokyo, 187-8551, Japan
Contact Phone: •••-•••-••••
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National Kohnodai Medical Center.
RECRUITINGIchikawa, Chiba, 272-8516, Japan
Contact Phone: •••-•••-••••
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Neuro-Behavioral Clinical Research
RECRUITINGNorth Canton, Ohio, 44720, United States
Contact Phone: •••-•••-••••
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North Shore Hospital
RECRUITINGAuckland, 0622, New Zealand
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Obihiro Kosei Hospital
RECRUITINGObihiro, Hokkaido, 080-0024, Japan
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Okehazama Hospital
RECRUITINGToyoake, Aichi-ken, 470-1168, Japan
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Osaka Metropolitan University Hospital
RECRUITINGOsaka, 545-8586, Japan
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Petz Aladar Egyetemi Oktato Korhaz
RECRUITINGGyőr, Győr-Moson-Sopron, 9024, Hungary
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Pillar Clinical Research - Bentonville
RECRUITINGBentonville, Arkansas, 72712, United States
Contact Phone: •••-•••-••••
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Pillar Clinical Research - Richardson
RECRUITINGRichardson, Texas, 75080, United States
Contact Phone: •••-•••-••••
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Pillar Clinical Research -Chicago
RECRUITINGChicago, Illinois, 60641, United States
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Rainbow and Sea Hospital
RECRUITINGKaratsu-shi, Saga-ken, 847-0031, Japan
Contact Phone: •••-•••-••••
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Ramsay Clinic New Farm
RECRUITINGBrisbane, Queensland, 4005, Australia
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Ramsay Clinic Northside
RECRUITINGSt Leonards, New South Wales, 2065, Australia
Contact Phone: •••-•••-••••
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Research Centers of America ( Hollywood )
RECRUITINGHollywood, Florida, 33024, United States
Contact Phone: •••-•••-••••
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Richmond Behavioral Associates
RECRUITINGStaten Island, New York, 10314, United States
Contact Phone: •••-•••-••••
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Saitama Konan Hospital
RECRUITINGKumagaya, Saitama, 360-0114, Japan
Contact Phone: •••-•••-••••
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Sanatorio Morra S.A.
RECRUITINGCórdoba, 5000, Argentina
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Semmelweis Egyetem
RECRUITINGBudapest, 1083, Hungary
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Showa Medical University Karasuyama Hospital
RECRUITINGTokyo, 157-8577, Japan
Contact Phone: •••-•••-••••
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South Florida Research Phase I-IV
RECRUITINGMiami, Florida, 33166, United States
Contact Phone: •••-•••-••••
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State Psychiatric Hospital Sv. Ivan Rilski Novi Iskar
RECRUITINGNovi Iskar, 1282, Bulgaria
Contact Phone: •••-•••-••••
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Synexus Clinical Research US, Inc.
RECRUITINGAtlanta, Georgia, 30328, United States
Contact Phone: •••-•••-••••
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Wakayama Medical University Hospital
RECRUITINGWakayama, 641-8510, Japan
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Woodland International Research Group
RECRUITINGLittle Rock, Arkansas, 72211, United States
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Yamagata Sakuracho Hospital
RECRUITINGYamagata, 990-0045, Japan
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