New pill aims to calm Alzheimer's psychosis in landmark trial

NCT ID NCT06540833

First seen Jun 27, 2026 · Last updated Jul 31, 2026 · Updated 4 times

Summary

This study tests an experimental drug, ITI-1284, to see if it can safely reduce psychosis symptoms like hallucinations and delusions in people with Alzheimer's disease. About 370 participants will receive either the drug or a placebo, and doctors will track changes in symptom severity over time. The goal is to improve quality of life for patients and their caregivers.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for ALZHEIMER DISEASE are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • ATP Clinical Research

    COMPLETED

    Orange, California, 92866, United States

  • Advanced Research Center, Inc

    RECRUITING

    Anaheim, California, 92805, United States

  • Allied Biomedical Research Institute (ABRI), Inc

    RECRUITING

    Miami, Florida, 33155-4630, United States

  • Ambulatory for Individual Practice for Specialized Medical Care in Psychiatry Dr. Ivo Natsov ET

    RECRUITING

    Cherven Bryag, 5980, Bulgaria

  • Bio Behavioral Health

    RECRUITING

    Toms River, New Jersey, 08755, United States

  • Brain Matters Research

    COMPLETED

    Delray Beach, Florida, 33445, United States

  • Centrul de Evaluarea si Tratament al Toxicodependentelor pentru Tineri Sf. Stelian

    SUSPENDED

    Bucharest, 60222, Romania

  • Clinical Center Dr Dragisa Misovic Dedinje

    RECRUITING

    Belgrade, 11000, Serbia

  • Clinical Research of Brandon

    SUSPENDED

    Brandon, Florida, 33511, United States

  • Combined Research Orlando

    COMPLETED

    Orlando, Florida, 32803, United States

  • Crystal Comfort s.r.o.

    RECRUITING

    Vranov nad Topľou, 09301, Slovakia

  • DCC 'Sv. Vrach and Sv. Sv. Kuzma and Damyan', OOD

    RECRUITING

    Sofia, 1408, Bulgaria

  • Envision Trials LLC

    RECRUITING

    Bonita Springs, Florida, 34134, United States

  • Epamed sro

    RECRUITING

    Košice, 4001, Slovakia

  • Fakultni nemocnice u sv. Anny v Brne

    RECRUITING

    Brno, 60200, Czechia

  • Healthcare Innovations Institute Inc

    COMPLETED

    Coral Springs, Florida, 33067, United States

  • Homestead Associates in Research Inc

    RECRUITING

    Homestead, Florida, 33033, United States

  • Horizon Clinical Research Group

    RECRUITING

    Cypress, Texas, 77065, United States

  • Hosp. Gral. de Albacete

    RECRUITING

    Albacete, 02006, Spain

  • Hosp. Prov. de Zamora

    RECRUITING

    Zamora, 49021, Spain

  • Hosp. Viamed Montecanal

    SUSPENDED

    Zaragoza, 50012, Spain

  • INEP medical s.r.o.

    COMPLETED

    Prague, 18600, Czechia

  • Intercoastal Medical Group

    RECRUITING

    Sarasota, Florida, 34239, United States

  • K2 Medical Research

    RECRUITING

    Maitland, Florida, 32751, United States

  • Medical Center Hera EOOD

    RECRUITING

    Sofia, 1510, Bulgaria

  • Medical Center Intermedica, OOD

    RECRUITING

    Sofia, 1680, Bulgaria

  • Medical Center Sv Dimitar Blagoevgrad

    RECRUITING

    Blagoevgrad, 2700, Bulgaria

  • Mental Health Center - Vratsa EOOD

    COMPLETED

    Vratsa, 3000, Bulgaria

  • Mental Health Centre Prof. N Shipkovenski EOOD

    RECRUITING

    Sofia, 1377, Bulgaria

  • NEURES s r o

    RECRUITING

    Krompachy, 05342, Slovakia

  • NEUROHK s r o

    RECRUITING

    Hradec Králové, 50002, Czechia

  • Neuro Care

    COMPLETED

    Katowice, 40-749, Poland

  • Neuro Health Centrum s r o

    RECRUITING

    Brno, 62800, Czechia

  • Neurologicka ambulancia MUDr.Dupejova s.r.o.

    COMPLETED

    Banská Bystrica, 97404, Slovakia

  • New Hope Clinical Research

    RECRUITING

    Charlotte, North Carolina, 28211, United States

  • Northwest Clinical Research Center

    RECRUITING

    Bellevue, Washington, 98007, United States

  • Ocean Blue Medical Research Center Inc.

    SUSPENDED

    Miami, Florida, 33144, United States

  • Osrodek Badawczo Naukowo Dydaktyczny Chorob Otepiennych UM im Piastow Slaskich we Wroclawiu

    RECRUITING

    Ścinawa, 59-330, Poland

  • Pharmacology Research Institute

    TERMINATED

    Los Alamitos, California, 90720, United States

  • Polyclinic Neuron

    RECRUITING

    Zagreb, 10000, Croatia

  • Przychodnia Srodmiescie SP. z o.o.

    COMPLETED

    Bydgoszcz, 85 080, Poland

  • Psych Me Medical Research Inc

    SUSPENDED

    Tampa, Florida, 33614, United States

  • Psychiatric Clinic "VRAPCE"

    RECRUITING

    Zagreb, 10090, Croatia

  • SC Carpe Diem SRL

    RECRUITING

    Sibiu, 550281, Romania

  • Science Connections LLC

    RECRUITING

    Doral, Florida, 33178, United States

  • South Florida Research Phase I-IV

    RECRUITING

    Miami, Florida, 33166, United States

  • Special Hospital for Psychiatric Diseases Kovin

    COMPLETED

    Kovin, 26220, Serbia

  • Special Hospital for Psychiatric Diseases Sveti Vracevi

    RECRUITING

    Novi Kneževac, 23330, Serbia

  • Spitalul Clinic de Psihiatrie Prof Dr Alexandru Obregia

    RECRUITING

    Bucharest, 041914, Romania

  • Spitalul Clinic de Psihiatrie Prof Dr Alexandru Obregia 1

    RECRUITING

    Bucharest, 040874, Romania

  • Spitalul De Psihiatrie Elisabeta Doamna Galaţi

    RECRUITING

    Galati, 800179, Romania

  • Spitalul Universitar de Urgenta Militar Central 'Dr. Carol Davila'

    RECRUITING

    Bucharest, 010825, Romania

  • Sunshine Medical Solution

    RECRUITING

    Miami, Florida, 33186, United States

  • Sunwise Clinical Research

    RECRUITING

    Walnut Creek, California, 94596, United States

  • UMHAT Prof. Dr. St. Kirkovich AD

    RECRUITING

    Stara Zagora, 6003, Bulgaria

  • University Clinical Center Kragujevac

    RECRUITING

    Kragujevac, 34000, Serbia

  • University Clinical Center NIS

    RECRUITING

    Niš, 18000, Serbia

  • University Hospital Centre Zagreb

    SUSPENDED

    Zagreb, 10000, Croatia

  • University Hospital Centre Zagreb 1

    COMPLETED

    Zagreb, 10000, Croatia

  • University of South Florida

    RECRUITING

    Tampa, Florida, 33613, United States

  • University of Texas Health Science Center at San Antonio

    RECRUITING

    San Antonio, Texas, 78229-3900, United States

  • Univerzitna nemocnica Bratislava

    RECRUITING

    Bratislava, 81369, Slovakia

  • Univerzitna nemocnica L. Pasteura Kosice

    RECRUITING

    Košice, 04190, Slovakia

  • Wellness Research Center

    RECRUITING

    Miami, Florida, 33135, United States

  • Wr Pri Llc

    COMPLETED

    Newport Beach, California, 92660, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.