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Blood pressure drug may curb aggression in autism

NCT ID NCT07091279

Recruiting now Disease control Sponsor: Jeremy Veenstra-vanderweele Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether propranolol, a common blood pressure medication, can reduce aggression, self-injury, and severe disruptive behaviors in autistic adolescents and adults. Sixty participants will receive either propranolol or a placebo for 12 weeks, with the option to take propranolol afterward. The goal is to see if the drug is safe and effective for managing these challenging behaviors.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Propranolol (a blood pressure medication) taken orally
What this could lead to
If it works, this could offer a new medication option to help manage severe challenging behaviors in autistic individuals.
What could go wrong
This is an early phase 2 trial with only 60 people, so results may not apply to everyone. Propranolol can cause side effects like low blood pressure and slow heart rate.

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Conditions

The condition(s) this trial relates to.

Aggression autism autism spectrum disorder disruptive behavior disorder Problem Behavior Self-Injurious Behavior

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AGGRESSION AUTISM SPECTRUM DISORDER CHALLENGING BEHAVIOUR SELF-INJURY SEVERE DISRUPTIVE BEHAVIOUR DISORDERS

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Center for Autism and the Developing Brain

    RECRUITING

    White Plains, New York, 10605, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

    Contact

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • New York State Institute for Basic Research (IBR)

    RECRUITING

    Staten Island, New York, 10314, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

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