Magic mushroom compound tested for stubborn bipolar depression

NCT ID NCT06943573

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a single 25 mg dose of psilocybin, given with therapy, can ease depression in people with bipolar II disorder who haven't improved with standard treatments. About 90 adults aged 19-65 will receive either the full dose or a very low placebo dose, and their mood changes will be tracked over 12 weeks. The goal is to see if this approach is safe and effective for treatment-resistant symptoms.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

bipolar disorder bipolar II disorder Depression major depressive disorder mood disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Department of Psychiatry, University of Ottawa, The Ottawa Hospital

    Ottawa, Ontario, K1H 8L6, Canada

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Department of Psychiatry, University of Toronto, University Health Network,

    Toronto, Ontario, M5T 2S8, Canada

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Djavad Mowafaghian Centre for Brain Health

    Vancouver, British Columbia, V6T 1Z3, Canada

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact Phone: •••-•••-•••• Email: •••••@•••••