Magic mushroom compound could restore joy in depressed patients

NCT ID NCT07607938

First seen May 31, 2026

Summary

This early-stage study tests whether a single 25 mg dose of psilocybin can help people who still feel emotionally flat or uninterested in things despite taking antidepressants. About 90 adults aged 18-65 will receive either psilocybin or a placebo, and researchers will use brain scans and questionnaires to measure changes in mood and brain activity. The goal is to see if psilocybin can safely improve these lingering symptoms.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • NYU Langone Health

    New York, New York, 10016, United States

Conditions

The condition(s) this trial relates to.

Anhedonia Depression major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.