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Magnetic brain pulses could offer Drug-Free hope for teen depression

NCT ID NCT06523439

NEW Recruiting now Disease control Sponsor: University of Texas at Austin Source: ClinicalTrials.gov ↗

First seen Aug 19, 2026 · Last updated Aug 19, 2026

Summary

This trial tests whether a new form of transcranial magnetic stimulation (TMS), called accelerated intermittent theta burst stimulation (aiTBS), can ease depression in adolescents aged 13-20 who haven't yet tried other treatments. Participants receive five days of aiTBS sessions, guided by brain scans, and stay off antidepressants during the study. Researchers will measure depression symptoms before and after treatment to see if aiTBS is both effective and acceptable as a first-line therapy.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
accelerated intermittent theta burst stimulation (aiTBS), a form of transcranial magnetic stimulation (TMS)
What this could lead to
If it works, this could offer a drug-free first-line option for teens with depression, potentially easing symptoms without the side effects of antidepressants.
What could go wrong
This is a small, early-stage trial, so results may not apply broadly. TMS can cause scalp discomfort or headache, and the treatment may not relieve depression for everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Depression depressive disorder major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DEPRESSION DEPRESSION IN ADOLESCENCE MAJOR DEPRESSIVE DISORDER MAJOR DEPRESSIVE EPISODE

Contacts and locations

Locations

  • Dell Medical School at University of Texas at Austin

    RECRUITING

    Austin, Texas, 78731, United States

    Contact Email: •••••@•••••

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