Can exercise boost fitness and breathing in severe mental illness?
NCT ID NCT07758049
First seen Aug 11, 2026 · Last updated Aug 14, 2026 · Updated 2 times
Summary
This study tests a 12-week supervised exercise program for adults with severe mental illness, such as schizophrenia, bipolar disorder, or major depression. The program combines cycling, strength training, and breathing exercises in twice-weekly sessions. Researchers will measure changes in fitness, strength, breathing, and body composition, and also assess how well participants stick with the program and their experiences. The goal is to see if this type of program is feasible, safe, and acceptable, and what physical health benefits it may offer.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- A supervised multicomponent exercise program combining interval aerobic training, resistance training, and inspiratory muscle training, delivered twice weekly for 12 weeks.
- What this could lead to
- If successful, this program could offer a practical, acceptable way to improve physical health and quality of life for people with severe mental illness, potentially reducing their risk of early death.
- What could go wrong
- This is a small, single-arm study without a comparison group, so any benefits seen might not be solely due to the exercise. Adherence may be challenging, and results may not apply to all individuals with severe mental illness.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Centro de Investigación en Rendimiento Físico y Deportivo (CIRFD), Universidad Pablo de Olavide
Seville, SEVILLA, 41013, Spain
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