Sound waves to silence depression's inner critic?
NCT ID NCT04832685
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether low intensity focused ultrasound can change negative thought patterns in people with depression. Researchers will target a key brain network involved in mind-wandering and self-judgment. 80 participants will receive both real and sham ultrasound sessions to see if it reduces rumination and negative self-judgment.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
low intensity focused ultrasound (BrainSonix Pulsar 1002 device)
What this could lead to
If it works, this could point toward a non-invasive brain stimulation treatment for depression that reduces rumination and negative self-judgment.
What could go wrong
This is a small early feasibility study (80 people) testing only short-term effects. It may not lead to a lasting treatment, and the ultrasound approach is still experimental.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Massachusetts General Hospital
Boston, Massachusetts, 02114, United States