Sound waves to silence depression's inner critic?
NCT ID NCT04832685
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether low intensity focused ultrasound can change negative thought patterns in people with depression. Researchers will target a key brain network involved in mind-wandering and self-judgment. 80 participants will receive both real and sham ultrasound sessions to see if it reduces rumination and negative self-judgment.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- low intensity focused ultrasound (BrainSonix Pulsar 1002 device)
- What this could lead to
- If it works, this could point toward a non-invasive brain stimulation treatment for depression that reduces rumination and negative self-judgment.
- What could go wrong
- This is a small early feasibility study (80 people) testing only short-term effects. It may not lead to a lasting treatment, and the ultrasound approach is still experimental.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Massachusetts General Hospital
Boston, Massachusetts, 02114, United States
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