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New depression pill shows promise in Late-Stage trial

NCT ID NCT06941844

Ongoing Symptom relief Sponsor: Definium Therapeutics US, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 11, 2026 · Updated 6 times

Summary

This study tests an oral medication called MM120 against a placebo in adults with major depressive disorder. The trial has two parts: a 12-week blinded phase followed by a 40-week open-label extension where everyone gets MM120. The main goal is to see if MM120 reduces depression symptoms more than placebo over 6 weeks.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MAJOR DEPRESSIVE DISORDER

Contacts and locations

Locations

  • Adams Clinical

    Watertown, Massachusetts, 02472, United States

  • Adams Clinical Boston

    Boston, Massachusetts, 02116, United States

  • Adams Clinical Harlem

    New York, New York, 10029, United States

  • Adams Clinical Philadelphia

    Philadelphia, Pennsylvania, 19104, United States

  • Austin Clinical Trial Partners

    Austin, Texas, 78737, United States

  • Cedar Clinical Research

    Murray, Utah, 84020, United States

  • Cenexel HRI

    Berlin, New Jersey, 08053, United States

  • Charter Research

    Orlando, Florida, 32803, United States

  • Clinical Neuroscience Solutions, Inc - Jacksonville

    Jacksonville, Florida, 32256, United States

  • Clinical Neuroscience Solutions, Inc - Memphis

    Memphis, Tennessee, 38119, United States

  • Clinical Neuroscience Solutions, Inc - Orlando

    Orlando, Florida, 32801, United States

  • Columbia - New York State Psychiatric Institute

    New York, New York, 10032, United States

  • Kadima Neuropsychiatry Institute

    La Jolla, California, 92037, United States

  • Memory Clinic, Inc

    Bennington, Vermont, 05201, United States

  • Mountain View Clinical Research, Inc

    Denver, Colorado, 80209, United States

  • Neuro-Behavioral Clinical Research

    Canton, Ohio, 44720, United States

  • Preferred Research Partners, Inc

    Little Rock, Arkansas, 72211, United States

  • Psychedelic Science Institute

    Santa Monica, California, 90404, United States

  • Sheppard Pratt

    Baltimore, Maryland, 21204, United States

  • University of Cincinnati

    Cincinnati, Ohio, 45219, United States

  • University of Missouri

    Columbia, Missouri, 65212, United States

  • Uptown Research Institute (URI), LLC

    Chicago, Illinois, 60640, United States

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