Can a natural brain chemical sharpen thinking in schizophrenia?

NCT ID NCT05046353

Terminated Symptom relief Sponsor: New York State Psychiatric Institute Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether D-serine, a natural brain chemical, can improve learning and memory in people with schizophrenia. Participants take D-serine or a placebo for 16 weeks while doing auditory training exercises. The goal is to see if D-serine helps the brain adapt and learn better.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: D-serine
What this could lead to: If it works, this could point toward a way to improve memory and thinking in people with schizophrenia.
What could go wrong: This is an early-phase trial that is currently suspended, so results are uncertain. D-serine may not provide meaningful cognitive benefits, and side effects are possible.

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Conditions

The condition(s) this trial relates to.

Psychotic Disorders schizoaffective disorder schizophrenia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SCHIZO AFFECTIVE DISORDER SCHIZOPHRENIA

Contacts and locations

Locations

NYSPI

New York, New York, 10032, United States

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