Can a dopamine-blocking drug safely control tourette syndrome over years?

NCT ID NCT06021522

Ongoing Disease control Sponsor: Emalex Biosciences Inc. Source: ClinicalTrials.gov ↗

First seen Jul 22, 2026 · Last updated Jul 23, 2026 · Updated 1 time

Summary

This trial investigates the long-term safety of ecopipam, a drug that blocks dopamine D1 and D5 receptors, in children, adolescents, and adults with Tourette syndrome. Participants who completed a prior study may enroll and receive ecopipam for up to 24 weeks or longer. The main goal is to track side effects and tolerability over time.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ecopipam tablets, a drug that blocks dopamine D1 and D5 receptors
What this could lead to: If safe and effective, ecopipam could offer a new long-term treatment option for people with Tourette syndrome.
What could go wrong: This is an open-label study with no placebo comparison, so results may be biased. Long-term safety data are still being collected.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

brain disorder central nervous system disorder movement disorder nervous system disorder neurodegenerative disease neurodevelopmental disorder psychiatric disorder tic disorder Tourette syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TOURETTE SYNDROME

Contacts and locations

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Locations

APG Research, LLC

Orlando, Florida, 32803, United States
ASMP-IP- d-r Kayryakova

Sofia, Sofia-Grad, 1360, Bulgaria
Access Clinical Trials, Inc.

Nashville, Tennessee, 37203-6502, United States
Access Clinical Trials, Inc.

Nashville, Tennessee, 37203, United States
Advanced Research Center

Anaheim, California, 92805, United States
Alivation Research

Lincoln, Nebraska, 68526, United States
Arkansas Children's Hospital

Little Rock, Arkansas, 72202, United States
Azienda Ospedaliero Universitaria " G. Rodolico - San Marco"

Catania, 95123, Italy
Bethesda Childrens Hospital(Magyarországi Református Egyház Bethesda Gyermekkórháza)

Budapest, 1146, Hungary
Boston Childrens Hospital

Boston, Massachusetts, 02115, United States
Cedar Clinical Research

Draper, Utah, 84020, United States
CenExel CIT-IE

Bellflower, California, 90706, United States
Center Spectar-Plovdiv

Plovdiv, Bulgaria, 4004, Bulgaria
Centrum Medyczne Plejady

Krakow, 30-363, Poland
Childrens National Hospital

Washington D.C., District of Columbia, 20010, United States
Cincinnati Children's Hospital Medical Center

Cincinnati, Ohio, 45229, United States
Clinic of Neurology and Psychiatry for Children and Adolescents

Belgrade, Grad Beograd, 1100, Serbia
Clinical Centre Nis Center of Mental Health

Niš, Serbia, 18000, Serbia
Clinical Research Center Sp. z o.o. MEDIC-R Sp.k.

Poznan, Wielkopolska, 61-731, Poland
Coastal Pediatric Research

Charleston, South Carolina, 29414, United States
Core Clinical Research

Everett, Washington, 98201, United States
Cortica Site Network

Glendale, California, 91203, United States
Cortica Site Network - San Rafael

San Rafael, California, 94903, United States
Florida International Research Center

Miami, Florida, 33173, United States
Gdanskie Centrum Zdrowia Sp z o.o.

Gdansk, Pomeranian Voivodeship, 80-542, Poland
Harmonex, Inc.

Dothan, Alabama, 36303, United States
Hospital General Universitario Gregorio Maranon

Madrid, Madrid, 28007, Spain
Hospital Universitario 12 de Octubre

Madrid, Madrid, 28041, Spain
Hospital Universitario Central de Asturias

Oviedo, Principality of Asturias, 33011, Spain
Hospital Universitario Virgen del Rocío

Seville, Sevilla, 41013, Spain
IRCCS Istituto Neurologico Carlo Besta

Milan, 20133, Italy
Institute of Mental Health

Belgrade, Belgrad, 11120, Serbia
Istituto Giannina Gaslini, Universita di Genova

Genova, GE, 16148, Italy
Josephson-Wallack-Munshower Neurology

Indianapolis, Indiana, 46256, United States
Kalimat Medical Center_Sofia

Sofia, 1680, Bulgaria
Kennedy Krieger Institute

Baltimore, Maryland, 21205, United States
Lurie Children Hospital of Chicago

Chicago, Illinois, 60611, United States
Mass General Hospital

Boston, Massachusetts, 02114, United States
Medical Research Group of Central Florida

Orange City, Florida, 32763, United States
Michigan Clinical research Institute PC

Ann Arbor, Michigan, 48105, United States
NW FL Clinical Research Group, LLC

Gulf Breeze, Florida, 32561, United States
National Childrens Hospital - The Ohio State University

Columbus, Ohio, 43205, United States
Neurobahavioral Medicine Group

Bloomfield Hills, Michigan, 48302, United States
Neurologia Śląska Centrum Medyczne

Katowice, Poland, 40-689, Poland
North Star Medical Research, LLC

Middleburg Heights, Ohio, 44130, United States
OnSite Clinical Solutions LLC

Charlotte, North Carolina, 28211, United States
Ospedale Pediatrico Bambino Ges

Roma, RM, 165, Italy
Pediatric Epilepsy and Neurology Specialists

Tampa, Florida, 33609, United States
Providence Brain and Spine Institute

Portland, Oregon, 97225, United States
Rare Disease Research, LLC

Atlanta, Georgia, 30329, United States
Research in Miami Inc

Hialeah, Florida, 33013-3834, United States
Road Runner Research, Ltd

San Antonio, Texas, 78249, United States
Rush University Medical Center

Chicago, Illinois, 60612, United States
St. Louis Children's Hospital

St Louis, Missouri, 63110, United States
Szegedi Tudomanyegyetem Altalanos Orvostudomanyi Kar Gyermek-es Ifjusagpszicihatria

Szeged, Hungary, 6720, Hungary
The Kids Clinic Inc

Ajax, Ontario, L1Z 0M1, Canada
The University of Texas Health Science Center at Houston

Houston, Texas, 77030, United States
UT Southwestern

Dallas, Texas, 75390, United States
Umass Chan Medical School

Worcester, Massachusetts, 01655, United States
Universita degli Studi di Napoli Federico II

Naples, Napoli, 80131, Italy
University of Louisville Research Foundation Inc.

Louisville, Kentucky, 40202, United States
University of Miami Miller School of Medicine

Miami, Florida, 33136, United States
University of Rochester

Rochester, New York, 14642, United States
University of South Florida

St. Petersburg, Florida, 33701, United States
Vanderbilt University Medical Center

Nashville, Tennessee, 37232-2551, United States
Wojewdzki Specjalistyczny Szpital Dziecicy im. sw. Ludwika w Krakowie

Krakow, Woj. Malopolskie, 31-503, Poland
Yale School of Medicine

New Haven, Connecticut, 06519, United States

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