Sound sleep: could a simple noise improve memory in schizophrenia?

NCT ID NCT04783571

Ongoing Knowledge-focused Sponsor: Massachusetts General Hospital Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study explores whether playing quiet sounds during a nap can help normalize brain activity and improve memory in people with schizophrenia. Researchers will compare memory and sleep patterns in 70 participants (healthy controls and schizophrenia patients) under two conditions: with and without auditory stimulation. The goal is to see if this simple, non-invasive approach can enhance sleep-related memory consolidation.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: auditory stimulation (quiet sounds played during sleep)
What this could lead to: If it works, this could point toward a simple, non-drug way to improve memory in schizophrenia.
What could go wrong: This is a small, early-stage study with only 70 participants. The effects may be small or not work at all, and results may not apply to everyone with schizophrenia.

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Conditions

The condition(s) this trial relates to.

schizophrenia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SCHIZOPHRENIA

Contacts and locations

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Locations

Massachusetts General Hospital

Boston, Massachusetts, 02114, United States

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