Mind over mood: new brain training targets Depression's repetitive thoughts
NCT ID NCT05933148
First seen Jun 18, 2026
Summary
This study tests whether real-time brain scans (fMRI) can help people with depression learn to reduce rumination—repetitive negative thinking. 80 participants will receive either real or sham neurofeedback while in a powerful 7T MRI machine. The goal is to strengthen a specific brain connection linked to mood, potentially offering a new way to ease depressive symptoms without medication.
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Icahn School Of Medicine at Mount Sinai
New York, New York, 10029, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
real-time fMRI neurofeedback
What this could lead to
If successful, this could offer a new, non-drug way to help people with depression break the cycle of repetitive negative thinking.
What could go wrong
This is an early, small study testing a complex brain-training technique. It may not work for everyone, and the effects might not last long-term.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.