Mind over mood: new brain training targets Depression's repetitive thoughts

NCT ID NCT05933148

Terminated Symptom relief Sponsor: Icahn School of Medicine at Mount Sinai Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether real-time brain scans (fMRI) can help people with depression learn to reduce rumination—repetitive negative thinking. 80 participants will receive either real or sham neurofeedback while in a powerful 7T MRI machine. The goal is to strengthen a specific brain connection linked to mood, potentially offering a new way to ease depressive symptoms without medication.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: real-time fMRI neurofeedback
What this could lead to: If successful, this could offer a new, non-drug way to help people with depression break the cycle of repetitive negative thinking.
What could go wrong: This is an early, small study testing a complex brain-training technique. It may not work for everyone, and the effects might not last long-term.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MAJOR DEPRESSIVE DISORDER

Contacts and locations

Locations

Icahn School Of Medicine at Mount Sinai

New York, New York, 10029, United States

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Other studies related to the condition(s) this trial covers.