Could a Vitamin-Like supplement boost language in kids with autism?

NCT ID NCT04060017

Ongoing Disease control Sponsor: Southwest Autism Research & Resource Center Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether leucovorin calcium, a vitamin-like supplement, can improve language and other symptoms in young children with autism spectrum disorder. Researchers will enroll 80 children aged 2.5 to 5 years with language delays. The trial lasts about 26 weeks and compares the supplement to a placebo.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: leucovorin calcium (a vitamin-like supplement)
What this could lead to: If it works, this could point toward a safe supplement to help improve language and other symptoms in young children with autism.
What could go wrong: This is a small, early-phase trial with only 80 children. Results may not apply to all kids with autism, and the supplement may not work better than placebo.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

autism spectrum disorder language disorder specific language impairment

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AUTISM SPECTRUM DISORDER LANGUAGE DISORDERS

Contacts and locations

Locations

Southwestern Autism Research & Resource Center

Phoenix, Arizona, 85016, United States
State University of New York, Downstate

Brooklyn, New York, 11203, United States

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