Blood pressure and eye tests may guide PTSD treatment

NCT ID NCT03539614

Ongoing Symptom relief Sponsor: VA Office of Research and Development Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Aug 14, 2026 · Updated 2 times

Summary

This Phase 3 trial tests whether two easy tests—measuring blood pressure changes when standing and eye reactions to light—can predict which veterans with PTSD will respond to the drug prazosin. The study involves 87 veterans and compares prazosin to a placebo. The goal is to personalize PTSD treatment by identifying who is most likely to benefit from this medication.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Prazosin (Minipress), a blood pressure drug also used for PTSD symptoms
What this could lead to: If successful, this could help doctors predict which PTSD patients will respond to prazosin, making treatment more personalized and effective.
What could go wrong: This is a small, early-stage biomarker study (87 veterans). The tests may not reliably predict response, and prazosin doesn't work for everyone. Results may not apply to non-veterans.

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Conditions

The condition(s) this trial relates to.

post-traumatic stress disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

POSTTRAUMATIC STRESS DISORDER

Contacts and locations

Locations

VA Puget Sound Health Care System Seattle Division, Seattle, WA

Seattle, Washington, 98108-1532, United States

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