Brain signals may explain impulsive actions in depressed teens

NCT ID NCT05652153

Recruiting now Knowledge-focused Sponsor: University of Minnesota Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study investigates why some adolescents act impulsively when experiencing negative emotions, a trait called negative urgency. Researchers will measure brain cell communication using transcranial magnetic stimulation and EEG in teens aged 13-21 with depression and suicidal thoughts or behaviors. Participants complete interviews, questionnaires, computer games, an MRI, and brain-signal tests at the start and again after 6 and 12 months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this research could point toward new ways to identify teens at higher risk for suicidal behavior based on brain signaling patterns.
What could go wrong: This is an observational study, not a treatment trial. It may not find clear links between brain signals and behavior, and results may not apply to all teens.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Depression depressive disorder Suicidal Ideation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CORTICAL INHIBITION DEPRESSION NEGATIVE URGENCY SUICIDAL BEHAVIOR SUICIDAL IDEATION

Contacts and locations

Locations

University of Minnesota
RECRUITING

Minneapolis, Minnesota, 55414, United States

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