Could a Head-Zap device lift depression in MS?

NCT ID NCT06901687

Recruiting now Symptom relief Sponsor: NYU Langone Health Source: ClinicalTrials.gov ↗

First seen Jun 29, 2026 · Last updated Jun 30, 2026 · Updated 1 time

Summary

This study tests whether a noninvasive brain stimulation technique called tDCS can reduce depression in people with multiple sclerosis. Participants use a headband-like device at home for 30 minutes a day over 30 days, while listening to mindfulness meditation. Half receive real stimulation, half receive a sham (placebo) version, and researchers compare changes in depression and MS symptoms.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: transcranial direct current stimulation (tDCS)
What this could lead to: If it works, this could offer a safe, non-drug option for managing depression in people with multiple sclerosis.
What could go wrong: This is a mid-stage trial with 170 participants, so results may not apply to everyone. The sham (placebo) group helps check if benefits are real, but the effect may be small.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Depression depressive disorder major depressive disorder multiple sclerosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DEPRESSION MULTIPLE SCLEROSIS

Contacts and locations

Locations

NYU Langone Health
RECRUITING

New York, New York, 10017, United States

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