Brain enzyme levels under scrutiny in depression study
NCT ID NCT05703685
First seen Jun 27, 2026 · Last updated Jul 02, 2026 · Updated 1 time
Summary
This study aims to see if people with major depressive disorder have lower levels of an enzyme called PDE4B in their brains compared to healthy volunteers. Researchers will use PET and MRI scans along with an experimental radioactive tracer to measure this enzyme. The study involves up to 5 clinic visits and includes both people with depression and healthy adults aged 18 to 70.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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National Institutes of Health Clinical Center
RECRUITINGBethesda, Maryland, 20892, United States
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