Scientists pinpoint ideal epidural dose for labor pain

NCT ID NCT05543694

Recruiting now Symptom relief Sponsor: Brigham and Women's Hospital Source: ClinicalTrials.gov ↗

First seen Jul 13, 2026 · Last updated Jul 14, 2026 · Updated 1 time

Summary

This study aims to find the dose of bupivacaine that effectively relieves labor pain in 90% of women receiving an epidural. Pregnant women at term with significant pain who request an epidural will receive a lidocaine test dose followed by a specific bupivacaine dose. The goal is to achieve a pain score below 3 out of 10, helping to standardize and improve initial labor analgesia.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: bupivacaine
What this could lead to: If successful, this could establish the optimal starting dose of bupivacaine for labor epidurals, improving pain relief for many women.
What could go wrong: This is a small, single-center dose-finding study, not a large trial. Results may not apply to all hospitals or patients, and individual responses vary.

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Conditions

The condition(s) this trial relates to.

agnosia Labor Pain pain agnosia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANALGESIA LABOR PAIN

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Brigham and Women's Hospital
RECRUITING

Boston, Massachusetts, 02115, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

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