Could a Psychedelic-Like pill beat depression? phase 3 trial underway

NCT ID NCT07592689

Recruiting now Symptom relief Sponsor: Definium Therapeutics US, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 11, 2026 · Updated 11 times

Summary

This phase 3 study is testing an oral drug called DT120 (related to LSD) against a placebo in 165 adults with major depressive disorder. Participants will take the drug or placebo for 12 weeks, followed by a 40-week period where everyone can receive DT120. The main goal is to see if DT120 reduces depression symptoms more than placebo, measured by a standard depression scale.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: DT120 (lysergide tartrate, a psychoactive substance that affects serotonin receptors)
What this could lead to: If successful, this could provide a new oral treatment option for major depressive disorder, potentially easing symptoms more effectively than current therapies.
What could go wrong: This is a phase 3 trial, but results may still fail to show significant benefit over placebo. The psychoactive nature of DT120 may cause side effects, and long-term safety is not yet fully established.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MAJOR DEPRESSIVE DISORDER

Contacts and locations

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Locations

ATP Clinical Research Orange County
NOT_YET_RECRUITING

Orange, California, 92866, United States
Adams Clinical Boston
RECRUITING

Boston, Massachusetts, 02116, United States
Adams Clinical Harlem
RECRUITING

New York, New York, 10029, United States
Adams Clinical Philadelphia
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
Adams Clinical Watertown
RECRUITING

Boston, Massachusetts, 02472, United States
Arch Clinical Trials, LLC
NOT_YET_RECRUITING

St Louis, Missouri, 63141, United States
Austin Clinical Trial Partners
RECRUITING

Austin, Texas, 78737, United States
Cedar Clinical Research
RECRUITING

Draper, Utah, 84020, United States
CenExel - Atlanta Center for Medical Research
RECRUITING

Atlanta, Georgia, 30331, United States
CenExel - iResearch Atlanta
RECRUITING

Decatur, Georgia, 30030, United States
CenExel - iResearch Savannah
RECRUITING

Savannah, Georgia, 31405, United States
Charter Research
NOT_YET_RECRUITING

Orlando, Florida, 32803, United States
Cleveland Clinic
NOT_YET_RECRUITING

Cleveland, Ohio, 44113, United States
Clinical Neuroscience Solutions, LLC (Jacksonville)
NOT_YET_RECRUITING

Jacksonville, Florida, 32256, United States
Clinical Neuroscience Solutions, LLC (Orlando)
NOT_YET_RECRUITING

Orlando, Florida, 32801, United States
Coastal Carolina Research
RECRUITING

North Charleston, South Carolina, 29405, United States
Inner Space Research
RECRUITING

Orem, Utah, 84058, United States
K2 Medical Research (Maitland)
NOT_YET_RECRUITING

Maitland, Florida, 32751, United States
K2 Medical Research (Tampa)
NOT_YET_RECRUITING

Tampa, Florida, 33607, United States
Kadima Neuropsychiatry Institute
RECRUITING

San Diego, California, 92037, United States
Memory Clinic Inc.
NOT_YET_RECRUITING

Bennington, Vermont, 05201, United States

Contact Email: •••••@•••••
Mountain View Clinical Research, Inc
RECRUITING

Denver, Colorado, 80209, United States
Preferred Research Partners, Inc.
RECRUITING

Little Rock, Arkansas, 72211, United States
Psychedelic Science Institute
RECRUITING

Santa Monica, California, 90404, United States

Contact Email: •••••@•••••
Redbird Research
RECRUITING

Las Vegas, Nevada, 89119, United States
Seattle Neuropsychiatric Treatment Center
NOT_YET_RECRUITING

Seattle, Washington, 98104, United States
UCSF Department of Neurology
NOT_YET_RECRUITING

San Francisco, California, 94158, United States
Uptown Research Institute
RECRUITING

Chicago, Illinois, 60640, United States
VA Portland Healthcare System
NOT_YET_RECRUITING

Vancouver, Washington, 98661, United States
Vitalix Clinical
RECRUITING

Worcester, Massachusetts, 01608, United States

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