New depression pill could lift the fog without lifelong dependence

NCT ID NCT06775379

Recruiting now Symptom relief Sponsor: Xenon Pharmaceuticals Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a new medication called azetukalner can reduce depression symptoms in adults with moderate-to-severe major depressive disorder. About 450 participants will receive either the drug or a placebo for 6 weeks. The main goal is to see if the drug improves mood and pleasure, as measured by standard depression scales.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

Depression major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MAJOR DEPRESSIVE DISORDER

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Accel Research Sites - St. Petersburg-Largo
RECRUITING

Largo, Florida, 33777, United States
Accel Research Sites Lakeland
RECRUITING

Lakeland, Florida, 33803, United States
Advanced Discovery Research
RECRUITING

Atlanta, Georgia, 30318, United States
Aim Trials, Llc
RECRUITING

Plano, Texas, 75093, United States
Atp Clinical Research
RECRUITING

Orange, California, 92866, United States
Behavioral Research Specialists, Llc
RECRUITING

Glendale, California, 91206, United States
Boston Clinical Trials Llc
RECRUITING

Boston, Massachusetts, 02131, United States
CNS Clinical Research Group
RECRUITING

Coral Springs, Florida, 33067, United States
CalNeuro Research Group, Inc.
RECRUITING

Los Angeles, California, 90025, United States
CenExel CNS-TO (Collaborative Neuroscience Research)
RECRUITING

Torrance, California, 90504, United States
CenExel iResearch
RECRUITING

Decatur, Georgia, 30030, United States
Cenexel Iresearch - Savannah
RECRUITING

Savannah, Georgia, 31405, United States
Chicago Research Center Inc.
RECRUITING

Chicago, Illinois, 60634, United States
Clinical Neuroscience Solutions, Inc.
RECRUITING

Jacksonville, Florida, 32256, United States
Clinical Neuroscience Solutions, Inc.
RECRUITING

Orlando, Florida, 32801, United States
Clinical Neuroscience Solutions, Inc.
RECRUITING

Memphis, Tennessee, 38119, United States
Combined Research Orlando Phase I-Iv
RECRUITING

Orlando, Florida, 32807, United States
Core Clinical Research
RECRUITING

Everett, Washington, 98201, United States
Ct Clinical Research Associates
RECRUITING

Cromwell, Connecticut, 06416, United States
Delricht Research - Plano
RECRUITING

Plano, Texas, 75024, United States
ELIXIA
RECRUITING

Springfield, Massachusetts, 01103, United States
Excell Research Inc.
RECRUITING

Oceanside, California, 92056, United States
Grayline Research Center
RECRUITING

Wichita Falls, Texas, 76309, United States
Harmony Clinical Research Inc
RECRUITING

North Miami Beach, Florida, 33162, United States
IMA Clinical Research
RECRUITING

Albuquerque, New Mexico, 87109, United States
IMA Clinical Research Las Vegas
RECRUITING

Las Vegas, Nevada, 89102, United States
IMA Clinical Research Phoenix
RECRUITING

Phoenix, Arizona, 85012, United States
Integrative Clinical Trials
RECRUITING

Brooklyn, New York, 11229, United States
Irvine Clinical Research
RECRUITING

Irvine, California, 92614, United States
Lehigh Center For Clinical Research
RECRUITING

Allentown, Pennsylvania, 18103, United States
Marvel Clinical Research
RECRUITING

Huntington Beach, California, 92647, United States
NeoClinical Research
RECRUITING

Hialeah, Florida, 33016, United States
New Hope Clinical Research
RECRUITING

Charlotte, North Carolina, 28211, United States
Northwest Clinical Trials Inc
RECRUITING

Boise, Idaho, 83704, United States
Nrc Research Institute
RECRUITING

Orange, California, 92868, United States
Pahl Pharmaceutical Professionals Llc
RECRUITING

Oklahoma City, Oklahoma, 73112, United States
Panhandle Research and Medical Clinic
RECRUITING

Pensacola, Florida, 32503, United States
PharmaSouth Research
RECRUITING

Miami, Florida, 33165, United States
Psych Atlanta, Pc
RECRUITING

Marietta, Georgia, 30060, United States
Quantum Clinical Trials
TERMINATED

Miami Beach, Florida, 33140, United States
Redbird Research
RECRUITING

Las Vegas, Nevada, 89119, United States
Richmond Behavioral Associates
RECRUITING

Staten Island, New York, 10314, United States
Sunwise Clinical Research
RECRUITING

Walnut Creek, California, 94596, United States
Synexus - Atlanta
RECRUITING

Atlanta, Georgia, 30328, United States
Woodland International Research Group
RECRUITING

Little Rock, Arkansas, 72211, United States
Woodland Research Northwest
RECRUITING

Rogers, Arkansas, 72758, United States