Can a brain pacemaker tame Treatment-Resistant depression?

NCT ID NCT03437928

Recruiting now Disease control Sponsor: Baylor College of Medicine Source: ClinicalTrials.gov ↗

First seen Jul 30, 2026 · Last updated Jul 31, 2026 · Updated 1 time

Summary

This trial investigates whether a next-generation deep brain stimulation (DBS) system can reduce symptoms in people with major depression that hasn't improved with standard treatments. The device uses directional current steering to precisely target brain networks thought to be involved in depression. Researchers aim to see if this individualized approach is safe and can lead to meaningful improvements in mood.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: directional deep brain stimulation using Boston Scientific Vercise leads and implanted pulse generators
What this could lead to: If successful, this could offer a new treatment option for people with severe depression that hasn't responded to other therapies.
What could go wrong: This is a small, early-stage trial with only 12 participants, so results may not apply broadly. Deep brain stimulation is an invasive brain surgery with risks such as infection, bleeding, or mood changes.

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Conditions

The condition(s) this trial relates to.

major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MAJOR DEPRESSIVE DISORDER

Contacts and locations

Locations

Baylor College of Medicine
ACTIVE_NOT_RECRUITING

Houston, Texas, 77030, United States
University of Texas Southwestern
RECRUITING

Dallas, Texas, 75390, United States

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