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Double brain zapping: could two stimulation methods beat depression?

NCT ID NCT05725239

Recruiting now Disease control Sponsor: Medical University of South Carolina Source: ClinicalTrials.gov ↗

First seen Jul 13, 2026 · Last updated Jul 14, 2026 · Updated 1 time

Summary

This study tests whether combining two types of stimulation—one that targets a nerve in the ear (or a surgically implanted neck device) and another that uses magnetic pulses on the scalp—can better relieve symptoms of treatment-resistant depression. Participants attend six treatment sessions, receiving each type alone or both together, to see which combination works best. The goal is to find a more effective option for people whose depression hasn't improved with standard treatments.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Vagus nerve stimulation (VNS) and transcranial magnetic stimulation (TMS)
What this could lead to
If it works, this combined approach could offer a new treatment option for people with depression that hasn't responded to standard therapies.
What could go wrong
This is a small, early-phase study with only 24 participants, so results may not apply broadly. The treatment may cause side effects or not improve symptoms significantly.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Depression depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DEPRESSION

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Medical University of South Carolina Institute of Psychiatry

    RECRUITING

    Charleston, South Carolina, 29412, United States

    Contact Email: •••••@•••••

    Contact Email: •••••@•••••

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